Questions and Answers About Gout.This fact sheet contains general information about gout gout, condition that manifests itself as recurrent attacks of acute arthritis, which may become chronic and deforming. It results from deposits of uric acid crystals in connective tissue or joints. . It describes what gout is and how it develops. It also explains how gout is diagnosed and treated. At the end is a list of key words to help you understand the terms used in this fact sheet. If you have further questions after reading this fact sheet, you may wish to discuss them with your doctor.
* What Is Gout?
* What Causes Gout?
* Who Is Likely To Develop Gout?
* How Is Gout Diagnosed?
* How Is Gout Treated?
* What Can People With Gout Do To Stay Healthy?
* What Research Is Being Conducted To Help People With Gout?
* Where Can People Find More Information About Gout?
* Key Words
What Is Gout?
Gout is one of the most painful rheumatic diseases. It results from deposits of needle-like crystals of uric acid uric acid (yr`ĭk), white, odorless, tasteless crystalline substance formed as a result of purine degradation in man, other primates, dalmatians, birds, snakes, and lizards. in the connective tissue, joint spaces, or both. These deposits lead to inflammatory arthritis, which causes swelling, redness, heat, pain, and stiffness in the joints. Arthritis is a term that is often used to refer to the more than 100 different rheumatic diseases that affect the joints, muscles, and bones, and may also affect other connective tissues. Gout accounts for about 5 percent of all cases of arthritis. Pseudogout, also a crystal-induced arthritis, is a condition with similar symptoms that results from deposits of calcium pyrophosphate Calcium pyrophosphate (Ca2O7P2) is a chemical compound that can be formed by the reaction of pyrophosphoric acid and a calcium base or by strongly heating calcium hydrogen orthophosphate or calcium ammonium orthophosphate. dihydrate crystals in the joints. It is sometimes called calcium pyrophosphate deposition disease calcium pyrophosphate deposition disease A disorder characterized by polymorphous arthropathies Clinical Pseudogout–acute crystal-induced synovitis or knee and/or wrist, arthropathy–osteophytes of 2nd and 3rd , crystal deposition disease, or chondrocalcinosis.
Uric acid is a substance that results from the breakdown of purines or waste products in the body. Normally, uric acid is dissolved in the blood and passes through the kidneys into the urine, where it is eliminated. If the body increases its production of uric acid or if the kidneys do not eliminate enough uric acid from the body, levels build up (a condition called hyperuricemia hyperuricemia /hy·per·uri·ce·mia/ (-u?ri-se´me-ah) uricemia; an excess of uric acid in the blood.hyperurice´mic
An unusually high concentration of uric acid in the blood. ). Hyperuricemia may also result when a person eats too many high-purine foods, such as liver, dried beans and peas, anchovies anchovies
a cause of diarrhea, vomiting, salivation, lacrimation, depression, miosis, polypnea, tachycardia, hypothermia in cats. , and gravies. Hyperuricemia is not a disease and by itself is not dangerous. However, if excess uric acid crystals form as a result of hyperuricemia, gout can develop. The excess crystals build up in the joint spaces, causing inflammation. Deposits of uric acid, called tophi Tophus (plural, tophi)
A chalky deposit of a uric acid compound found in gout. Tophi occur most frequently around joints and in the external ear.
Mentioned in: Gout , can appear as lumps under the skin around the joints and at the rim of the ear. In addition, uric acid crystals can also collect in the kidneys and cause kidney stones Kidney Stones Definition
Kidney stones are solid accumulations of material that form in the tubal system of the kidney. Kidney stones cause problems when they block the flow of urine through or out of the kidney. .
For many people, gout initially affects the joints in the big toe big toe
The largest and innermost toe of the human foot. , a condition called podagra podagra /po·dag·ra/ (pah-dag´rah) gouty pain in the great toe.
Gout, especially of the big toe. . Sometime during the course of the disease, gout will affect the big toe in about 75 percent of patients. Gout can also affect the instep instep /in·step/ (-step) the dorsal part of the arch of the foot.
The arched middle part of the foot between toes and ankle. , ankles, heels, knees, wrists, fingers, and elbows. The disease can progress through four stages:
* Asymptomatic (without symptoms) hyperuricemia--In this stage, a person has elevated levels of uric acid in the blood but no other symptoms. The tendency to develop gout, however, is present. A person in this stage does not usually require treatment.
* Acute gout, or acute gouty gout
1. A disturbance of uric-acid metabolism occurring chiefly in males, characterized by painful inflammation of the joints, especially of the feet and hands, and arthritic attacks resulting from elevated levels of uric acid in the blood arthritis--In this stage, hyperuricemia has caused the deposit of uric acid crystals in joint spaces. This leads to a sudden onset of intense pain and swelling in the joints, which may also be warm and very tender. An acute attack commonly occurs at night and can be triggered by stressful events, alcohol or drugs, or another acute illness. Early attacks usually subside sub·side
intr.v. sub·sid·ed, sub·sid·ing, sub·sides
1. To sink to a lower or normal level.
2. To sink or settle down, as into a sofa.
3. To sink to the bottom, as a sediment.
4. within 3 to 10 days, even without treatment, and the next attack may not occur for months or even years. Over time, however, attacks can last longer and occur more frequently.
* Interval or intercritical gout--This is the period between acute attacks. In this stage, a person does not have any symptoms and has normal joint function.
* Chronic tophaceous gout--This is the most disabling stage of gout and usually develops over a long period, such as 10 years. In this stage, the disease has caused permanent damage to the affected joints and sometimes to the kidneys. With proper treatment, most people with gout do not progress to this advanced stage.
What Causes Gout?
A number of risk factors are related to the development of hyperuricemia and gout:
* Genetics may play a role in determining a person's risk, since 6 to 18 percent of people with gout have a family history of the disease.
* Being overweight increases the risk of developing hyperuricemia and gout because excessive food intake increases the body's production of uric acid.
* Excessive use of alcohol can lead to hyperuricemia because it interferes with the removal of uric acid from the body.
* Eating too many foods that are rich in purines can cause or aggravate gout.
* An enzyme defect enzyme defect A structural or functional defect in an enzyme needed to catalyze a normal biochemical reaction in the body. See Enzyme, Inborn error of metabolism. that interferes with the way the body breaks down purines causes gout in a small number of people.
* Exposure to lead in the environment can cause gout.
Some people are at risk for high levels of uric acid in body fluids because of certain medicines they take or other conditions they may have. For example, the following types of medicines can lead to hyperuricemia because they reduce the body's ability to remove uric acid:
* Diuretics Diuretics Definition
Diuretics are medicines that help reduce the amount of water in the body.
Diuretics are used to treat the buildup of excess fluid in the body that occurs with some medical conditions such as congestive heart , which decrease the amount of uric acid passed in the urine. Many people take diuretics for hypertension, edema edema (ĭdē`mə), abnormal accumulation of fluid in the body tissues or in the body cavities causing swelling or distention of the affected parts. , or cardiovascular disease Cardiovascular disease
Disease that affects the heart and blood vessels.
Mentioned in: Lipoproteins Test
cardiovascular disease .
* Salicylates Salicylates
A group of drugs that includes aspirin and related compounds. Salicylates are used to relieve pain, reduce inflammation, and lower fever. , or medicines made from salicylic acid salicylic acid or 2-hydroxybenzoic acid, C6H4(OH)CO2H, a colorless, crystalline organic carboxylic acid that melts at 159°C;; it is soluble in ethanol and ether but is only slightly soluble in water. , such as aspirin.
* The vitamin niacin niacin: see coenzyme; vitamin.
or nicotinic acid or vitamin B3
Water-soluble vitamin of the vitamin B complex, essential to growth and health in animals, including humans. , also called nicotinic acid nicotinic acid: see coenzyme; vitamin. .
* Cyclosporine cyclosporine /cy·clo·spor·ine/ (-spor´en) a cyclic peptide from an extract of soil fungi that selectively inhibits T cell function; used as an immunosuppressant to prevent rejection in organ transplant recipients and to treat severe , a medicine used to control the body' s rejection of transplanted organs.
* Levodopa levodopa: see l-dopa.
Organic compound (L-3,4-dihydroxyphenylalanine) from which the body makes dopamine, a neurotransmitter deficient in persons with parkinsonism. , a medicine used to treat Parkinson's disease Parkinson's disease or Parkinsonism, degenerative brain disorder first described by the English surgeon James Parkinson in 1817. When there is no known cause, the disease usually appears after age 40 and is referred to as Parkinson's disease. .
Who Is Likely To Develop Gout?
Gout occurs in approximately 275 out of every 100,000 people. Men are more likely to develop gout than women, and men aged 40 to 50 are most commonly affected. Women rarely develop gout before menopause. The disease affects men and women differently: Men tend to develop gout at an earlier age than women, and alcohol is more often associated with the development of the disease in men. Gout is rare in children and young adults.
Signs and Symptoms of Gout
* Presence of uric acid crystals in joint fluid
* More than one attack of acute arthritis
* Arthritis that develops in 1 day
* Attack of arthritis in only one joint, usually the toe, ankle, or knee
* A painful joint that is swollen, red, and warm
How Is Gout Diagnosed?
Gout may be difficult for doctors to diagnose because the symptoms may be vague and often mimic other conditions. Although most people with gout have hyperuricemia at some time during the course of their disease, it may not be present during an acute attack. In addition, hyperuricemia alone does not mean that a person has gout. In fact, most people with hyperuricemia do not develop the disease.
To confirm a diagnosis of gout, doctors typically test the fluid in the joint, called synovial fluid synovial fluid: see joint. , by using a needle to draw a sample of fluid from a person's inflamed joint. The doctor places some of the fluid on a slide and looks for monosodium urate crystals Urate crystals
Crystals formed by high levels of uric acid in the blood.
Mentioned in: Gout under a microscope. If the person has gout, the doctor will almost always see crystals. Their absence, however, docs not completely rule out the diagnosis. Doctors may also find it helpful to examine joint or tophi deposits to diagnose gout. A doctor who suspects a joint infection may check for the presence of bacteria.
How Is Gout Treated?
With proper treatment, most people with gout are able to control their symptoms and live normal lives. Gout can be treated with one or a combination of therapies. Treatment goals are to case the pain associated with acute attacks, prevent future attacks, and avoid the formation of new tophi and kidney stones.
The most common treatments for an acute attack of gout are high doses of nonsteroidal anti-inflammatory drugs Nonsteroidal Anti-Inflammatory Drugs Definition
Nonsteroidal anti-inflammatory drugs are medicines that relieve pain, swelling, stiffness, and inflammation. (NSAID's) and injections of corticosteroid drugs into the affected joint. NSAID's reduce the inflammation caused by deposits of uric acid crystals. The NSAID's most commonly prescribed for gout are indomethacin indomethacin /in·do·meth·a·cin/ (in?do-meth´ah-sin) a nonsteroidal antiinflammatory drug; used in the treatment of various rheumatic and nonrheumatic inflammatory conditions, dysmenorrhea, and vascular headache. (Indocin_(1)) and naproxen naproxen and naproxen sodium, potent nonsteroidal anti-inflammatory drugs (NSAID) used to alleviate the minor pain of arthritis, menstruation, headaches, and the like, and to reduce fever. (Anaprox, Naprosyn), which are taken by mouth (orally) every day. Patients usually begin to improve within a few hours of treatment, and the attack goes away completely within a few days.
When NSAID's do not control symptoms, the doctor may consider using colchicine colchicine (kŏl`chəsēn'), alkaloid extracted from plants of the genus Colchicum and especially from the corms of the autumn crocus, Colchicum autumnale (see meadow saffron). . This drug is most effective when taken within the first 12 hours of an acute attack. Doctors can give colchicine by mouth (usually every hour until symptoms go away), or they can inject it directly into a vein (intravenously). When taken by mouth, colchicine frequently causes diarrhea.
For some people, the doctor may prescribe either NSAID's or oral colchicine in small daily doses to prevent future attacks. If attacks continue and tophi develop, however, the doctor may prescribe medicine to treat hyperuricemia, most commonly allopurinol allopurinol /al·lo·pur·i·nol/ (al?o-pur´i-nol) an isomer of hypoxanthine, capable of inhibiting xanthine oxidase and thus of reducing serum and urinary levels of uric acid; used in prophylaxis and treatment of hyperuricemia and uric acid (Zyloprim) and probenecid probenecid /pro·ben·e·cid/ (pro-ben´e-sid) a uricosuric agent used in the treatment of gout; also used to increase serum concentration of certain antibiotics and other drugs.
What Can People With Gout Do To Stay Healthy?
* To help prevent future attacks, take the medicines your doctor prescribes. Carefully follow instructions about how much medicine to take and when to take it. Acute gout is best treated when symptoms first occur.
* Tell your doctor about all the medicines and vitamins you take. He or she can tell you if any of them increase your risk of hyperuricemia.
* Plan followup visits with your doctor to evaluate your progress.
* Maintain a healthy, balanced diet balanced diet
A diet that furnishes in proper proportions all of the nutrients necessary for adequate nutrition.
balanced diet ; avoid foods that are high in purines; and drink plenty of fluids, especially water. Fluids help remove uric acid from the body.
* Exercise regularly and maintain a healthy body weight. Lose weight if you are overweight.
What Research Is Being Conducted To Help People With Gout?
Scientists are studying whether other NSAID's are effective in treating gout and are analyzing new compounds to develop safe, effective medicines to treat gout and other rheumatic diseases. For example, researchers are testing to determine whether fish oil supplements reduce the risk of gout. They are also studying the structure of the enzymes that break down purines in the body, in hopes of achieving a better understanding of the enzyme defects that can cause gout.
Where Can People Find More Information About Gout?
* Arthritis Foundation This article or section needs sources or references that appear in reliable, third-party publications. Alone, primary sources and sources affiliated with the subject of this article are not sufficient for an accurate encyclopedia article.
1330 West Peachtree Street Atlanta, GA 30309 404/872-7100 800/283-7800, or call your local chapter (listed in the telephone directory) World Wide Web address: http://www.arthritis.org/
This is the main voluntary organization devoted to arthritis. The foundation publishes free pamphlets on many types of arthritis and a monthly magazine for members that provides up-to-date information on arthritis. The foundation also provides physician and clinic referrals.
* National Arthritis and Museuloskeletal and Skin Diseases Information Clearinghouse (NAMSIC)
National Institutes of Health 1 AMS Circle Bethesda, MD 20892-3675 301/495-4484 TTY: 301/565-2966 Fax: 301/718-6366 NIAMS Fast Facts--For health information that is available by fax 24 hours a day, call 301/881-2731 from a fax machine telephone. World Wide Web address: http://www.niih.gov/niams/
This clearinghouse, a public service sponsored by the National Institute of Arthritis and Musculoskeletal and Skin Diseases The National Institute of Arthritis and Musculoskeletal and Skin Diseases, or NIAMS, is an institute of the National Institutes of Health, an agency of the United States Department of Health and Human Services. (NIAMS NIAMS National Institute of Arthritis, Musculoskeletal and Skin Diseases (USA) ), provides information about various forms of arthritis and rheumatic diseases. The clearinghouse distributes patient and professional education materials and also refers people to other sources of information.
The NIAMS gratefully acknowledges the assistance of John H. Klippel, M.D., NIAMS; N. Lawrence Edwards, M.D., of the University of Florida University of Florida is the third-largest university in the United States, with 50,912 students (as of Fall 2006) and has the eighth-largest budget (nearly $1.9 billion per year). UF is home to 16 colleges and more than 150 research centers and institutes. in Gainesville; and Lawrence Ryan, M.D., of the Medical College of Wisconsin, in the preparation and review of this fact sheet.
Key Words Arthritis: Literally means joint inflammation. It is a general term for more than 100 conditions known as rheumatic diseases. These diseases affect not only the joints, but also other parts of the body, including important supporting structures, such as muscles, tendons, and ligaments, as well as some internal organs. Cartilage: A tough, resilient tissue that covers and cushions the ends of the bones and absorbs shock. Colchicine: A medicine used to treat gout. It may be given by mouth (orally) or injected directly into a vein (intravenously). Connective tissue: The supporting framework of the body and its internal organs. Corticosteroids: Potent-anti-inflammatory hormones that are made naturally in the body or syntheti- cally for use as drugs. The most commonly prescribed corticosteroid is prednisone. Crystal-induced An accumulation of crystalline material arthritis: in various parts of the body, especially the joints. Gout and pseudogout are examples of crystal- induced arthritis. Gout: A type of arthritis caused by the body's reaction to needle-like crystals that accumulate in joint spaces. This reaction causes inflammation and extreme pain in the affected joint, most commonly the big toe. The crystals are formed from uric acid. Gout is caused by either increased production of uric acid or failure of the body to eliminate uric acid. Hyperuricemia: Increased amount of uric acid in the blood. Inflammation: A characteristic reaction of tissues to injury or disease. It is marked by four signs: swelling, redness, heat, and pain. Joint: A junction where two bones meet. Most joints are composed of cartilage, joint space, fibrous capsule, synovium, and ligaments. Joint space: The volume enclosed within the fibrous capsule. Ligaments Bands of cordlike tissue that connect bone to bone. Nonsteroidal A group of drugs, such as aspirin and anti-inflammatory drugs aspirin-like drugs, used to (NSAID's): reduce the inflammation that causes joint pain, stiffness, and swelling. Psendogout: Similar to gout; however, the crystals in the synovial fluid are composed of calcium pyrophosphate dihydrate and not uric acid. As in gout, the crystals in the joint space cause an intense inflammatory reaction in the joint. Purines: Components of all human tissue that break down to form uric acid. Purines are also found in many foods in varying amounts. Rheumatic diseases: A general term that refers to more than 100 conditions that affect joints, muscles, bones, and other connective tissues. Synovial fluid: A substance found around the joints that nourishes and lubricates them. Tendons: Fibrous cords of tissue that connect muscle to bone. Tophus (plural tophi): A hard deposit of crystalline uric acid that may appear as a lump just under the skin, particularly around the joints and at the rim of the ear. Uric acid: An organic substance that results from the breakdown of purines or waste products in the body. It is dissolved in the blood and passes through the kidneys into the urine, where it is eliminated. Most patients with gout have high levels of uric acid in their blood. If the concen- tration of uric acid in the tissues rises above normal levels, crystals can form in the joints and cause inflammation. Uric acid crystals: Caused by high concentrations of uric acid. When uric acid crystals form in the blood, they can collect in connective tissue, joints, and kidneys. Some kidney stones are made of uric acid.
(1) Brand names included in this fact sheet are provided as examples only, and their inclusion does not mean that these products are endorsed by the National Institutes of Health or any other Government agency. Also, if a particular brand name is not mentioned, this does not mean that the product is unsatisfactory.
The National Institute of Arthritis and Musculoskeletal and Skin Diseases (NIAMS), a part of the National Institutes of Health (NIH "Not invented here." See digispeak.
NIH - The United States National Institutes of Health. ), leads the Federal medical research effort in arthritis and musculoskeletal musculoskeletal /mus·cu·lo·skel·e·tal/ (-skel´e-t'l) pertaining to or comprising the skeleton and muscles.
Relating to or involving the muscles and the skeleton. and skin diseases. The NIAMS supports research and research training throughout the United States United States, officially United States of America, republic (2005 est. pop. 295,734,000), 3,539,227 sq mi (9,166,598 sq km), North America. The United States is the world's third largest country in population and the fourth largest country in area. , as well as on the NIH campus in Bethesda, MD, and disseminates health and research information. The National Arthritis and Musculoskeletal and Skin Diseases Information Clearinghouse (NAMSIC) is a public service sponsored by the NIAMS that provides health information and information sources. Additional information can be found on the NIAMS Web site at http://www.nih.gov/niams/.