Mutant monikers: a tale of freaky flies and gonzo geneticists.
Mutant Monikers A tale of Freaky freak·y
adj. freak·i·er, freak·i·est
1. Strange or unusual; freakish.
2. Slang Frightening.
freak flies and gonzo gon·zo
1. Using an exaggerated, highly subjective style, especially in journalism: "a hyperkinetic, gonzo version of Graham Greene" New Yorker.
2. geneticists This is a list of people who have made notable contributions to genetics. The growth and development of genetics represents the work of many people. This list of geneticists is therefore by no means complete. Contributors of great distinction to genetics are not yet on the list.
It's probably not fair to place all the blame on Thomas Morgan. But in a way it's his fault -- or, depending on how you look at it, his most outstanding accomplishment -- that mutant fruit flies today bear the strange names they do.
Hedgehog, ether a go-go, shaven baby and killer of prune are among the hundreds of weirdly named mutants that fruit fly geneticists today discuss seriously at scientific meetings.
True, Morgan himself didn't dream up most of these names. Indeed, the late U.S. biologist and 1933 Nobel laureate exhibited reasonable restraint in the way he named genes, waxing poetic at times but rarely venturing into the bizarre. It was his students -- and worse, his students' students -- who took the art of genetic nomenclature beyond the bounds of scientific reason, and in some cases beyond the limits of good taste.
Still, it was Morgan who nudged the movement into motion by molding the peculiar system of nomenclature that led to what one researcher calls "one of the richest sources of ridiculous names in the world" -- names like dunce, tricky dick and technical knockout.
Clearly, Morgan was an eccentric. He regularly ate the remains of sea urchins and other marine organisms he had used in experiments, claiming that "to know your organism, you must eat it." Rumor has it that when his research interests expanded from marine biology to insect genetics at Columbia University, he took to eating fruit fly pupae -- the brown, cocoon-enclosed maturing insects -- claiming they tasted like Grape Nuts.
Whatever his dietary habits, Morgan probably didn't know just what he was starting back in 1910 when he became the first to identify and name an inherited mutation in a fruit fly. The mutation left the normally red-eyed insects with pure white eyes, and he named the altered gene "white," abbreviating it w.
Logical as that decision may seem, Morgan could have done things differently. For example, he could have named the eye-color gene "red," or "eye color," or even "red eye," describing the normal state of affairs. Then he could have added symbolic suffixes to modifiers to describe various mutant forms of that gene, such as "[eye.sup.w]" for the mutation that causes white eyes. Indeed, geneticists working with other organisms have devised gene-name systems along such logical lines.
But for reasons that will remain forever unknown, Morgan chose to emphasize the appearance -- or, as geneticists say, the phenotype -- of the mutant form. And since the number of mutant phenotypes far exceeds that of normal phenotypes (strictly speaking, only one phenotype is "normal"), he threw open the door to a nomenclatural free-for-all that continues to this day. Fruit fly geneticists now rack their brains to think up amusing but descriptive names for the dozens of mutants discovered every year.
"It's a long-standing, whimsical tradition. It has to do with basic craziness," says Thomas C. Kaufman, a fruit fly geneticist ge·net·i·cist
A specialist in genetics.
a specialist in genetics.
geneticist at Indiana University in Bloomington who has contributed such esoteric gene names as fushi tatazu. Some scientists have spent months coming up with the perfect name for their mutation, or even longer to find a mutation for a strange name they'd like to use. But not just any clever name will do, Kaufman warns. "To work, it has to have a rationale."
Take, for example, a mutant gene mutant gene
A gene that has lost, gained, or exchanged some of the material it received from its parent, resulting in a permanent transmissible change in its function. discovered in 1963 by a Yale Unviersity researcher named Coolgeer Gill. Male flies bearing this genetic quirk engage in courtship rituals with other male flies instead of with females. Times being what they were, Gill named the gene "fruity," abbreviated as fru.
About a decade later, geneticist jeffrey C. Hall, now at Brandeis University in Waltham, Mass., conviced Gill that changing sensitivities about sexual preference had left the gene's name sounding a bit insulting. They agreed to rename the mutant "fruitless," a politically neutral moniker (1) A name, title or alias. See alias.
(2) A COM object that is used to create instances of other objects. Monikers save programmers time when coding various types of COM-based functions such as linking one document to another (OLE). See COM and OLE. that accurately describes the fly's inability to sire offspring while keeping the well-known abbreviation fru.
Peer pressure played a role in the development of other names, too. fruit flies, while not brilliant, can be trained to respond in particular ways to certain stimuli such as mild electrical shocks. Years ago, Seymour Benzer at the California Institute of Technology California Institute of Technology, at Pasadena, Calif.; originally for men, became coeducational in 1970; founded 1891 as Throop Polytechnic Institute; called Throop College of Technology, 1913–20. in Pasadena isolated a mutant strain that fails to learn. "It just can't remember anything," Benzer says of the mutant. He identified the responsible gene and named it dunce.
Before long, scientists discovered other learning-impaired mutants. William G. Quinn, for example, now at the Massachusetts Institute of Technology Massachusetts Institute of Technology, at Cambridge; coeducational; chartered 1861, opened 1865 in Boston, moved 1916. It has long been recognized as an outstanding technological institute and its Sloan School of Management has notable programs in business, in Cambridge, came up with several dullard mutants and came close to naming them and their mutant genes after famous retarded characters in literature, such as Lenny in Steinbeck's Of Mice and Men Of Mice and Men
story of George Milton and Lennie Small’s futile dream of having their own farm. [Am. Lit.: Of Mice and Men]
See : Futility
Of Mice and Men .
What happened next depends on whom you ask. Several geneticists say colleagues pressued Quinn to avoid the retardation theme, which mental health professionals and their clients might construe as demeaning de·mean 1
tr.v. de·meaned, de·mean·ing, de·means
To conduct or behave (oneself) in a particular manner: demeaned themselves well in class. . Quinn says he changed his mind on his own. In any case, many consider his ultimate decision to name the mutants after vegetables such as rutabaga rutabaga: see turnip.
Swedish turnip (Brassica napus) in the mustard family. A hardy biennial, the rutabaga is a cool-season plant cultivated for its fleshy roots and tender leaves. , turnip turnip, garden vegetable of the same genus of the family Cruciferae (mustard family) as the cabbage; native to Europe, where it has been long cultivated. The two principal kinds are the white (Brassica rapa) and the yellow (B. and cabbage only marginally more diplomatic.
Marty Chalfie, a geneticist at Columbia University, remembers an even stranger version. "The story I heard," Chalfie says, "was that he was first going to name them after stupid scientists."
Some names become period pieces. In the 1960s William D. Kaplan, now at the City of Hope Hospital in Duarte, Calif., discovered a mutant fruit fly that twitches and shakes when exposed to ether. "It was a period when everybody was talking about Whiskey a go-go and here was a fly that was doing this sort of dance," Kaplan recalls. "So we decided to name it ether a go-go to celebrate the era when it was discovered."
But Kaplan no longer works with the mutant. It's Barry E. Ganetzky at the University of Wisconsin-Madison “University of Wisconsin” redirects here. For other uses, see University of Wisconsin (disambiguation).
A public, land-grant institution, UW-Madison offers a wide spectrum of liberal arts studies, professional programs, and student activities. who has taken up that particular research gauntlet and who must now live with the name, which some scientists criticize as sounding "dated." Ganetzky admits that he's sometimes embarrassed to talk about the gene, even in fruit fly circles. "I almost never refer to it that way in a seminar," he says. "I always call it eag."
Ganetzky says that if he had discovered the gene, he probably would have given it another name. "But to tell you the truth, we have discovered several genes ourselves and given them names that order people probably think are equallys tupid." Indeed, Ganetzky confesses to having created a long list of adjectives that would make good names for peculiar but as-yet-undiscovered behavioral mutants.
Perhaps the most famous case of scientists having to stretch their imaginations to incorporate a name they wanted to use comes from the laboratory then headed by David T. Suzuki at the University of British Columbia Locations
The Vancouver campus is located at Point Grey, a twenty-minute drive from downtown Vancouver. It is near several beaches and has views of the North Shore mountains. The 7. in Vancouver. In the 1970s, Suzuki promised a hot fudge sundae to the person who suggested the best name for a newly discovered gene that left flies healthy at 22 [degrees] C but caused partial paralysis and a staggered gait at 29 [degrees] C. A laboratory technicial won the contest by coming up with hot [shi.sup.TS]. Shi is short for the Japanese word shibire, which means in essence "walks like a drunk." TS stands for temperature sensitive, while the prefix hot indicates that the mutant trait emerges only at warmer temperatures.
That's the way it goes sometimes, Kaufman says. "You start with the word you want to use, then you tru to think of an excuse so you can get ca-ca humor into the journals." Adds Thomas A. Grigliatti, who was working in the Suzuki lab when hot [shi.sup.TS] was named: "These things happen when people need more sleep than you recognize."
Other bizarre examples abound. A mutation that causes purplish-brown eyes goes by the name prune. a separate mutation that proves lethal only to flies carrying the prune mutation bears the name killer of prune.
Along similar lines, a family of names has sprung up around a mutation called sevenless, which leaves its victims missing the seventh of eight light receptors normally present in a fruit fly's eye. Phenotypically similar mutations now bear names such as bride of sevenless, son of sevenless In cell signalling, Son of Sevenless, or SOS, is a gene encoding a guanine nucleotide exchange factor that acts on Ras-GTPases. SOS is an orthologue of a gene originally found in Drosophila melanogaster and sevenless in absentia in absentia (in ab-sensh-ee-ah) adj. or adv. phrase. Latin for "in absence," or more fully, in one's absence. Occasionally a criminal trial is conducted without the defendant being present when he/she walks out or escapes after the trial has begun, since the accused .
Another mutation, which proves nearly fatal and which, in the words of one researcher, makes flies "look like they have no right to be alive," goes by the name living dead.
Other names relate to the bristle bristle
1. the thick strong animal fibers collected at commercial abattoirs for use in brushes.
2. the sharp serrated awns of grass and some cereal seeds that confer a capacity to penetrate normal skin and mucosa and to cause ulcerative stomatitis, grass seed abscess and the like. patterns on fruit fly larvae Larvae, in Roman religion
Larvae: see lemures. . Hedgehog lacks the bald segments that normally intervene between bristled bris·tle
1. A stiff hair.
2. A stiff hairlike structure: the bristles of a wire brush.
v. bris·tled, bris·tling, bris·tles
v.intr. segments, giving larvae an especially furry appearance, while shaven baby lacks bristles altogether.
The technical knockout gene, commonly called tko, leaves fruit flies so exquisitely sensitive to shock that a tap against the walls of their container leaves them flat on their backs and catatonic (jargon) catatonic - A description of a system that gives no indication that it is still working. This might be because it has crashed without being able to give any error message or because it is busy but not designed to give any feedback.
Compare buzz. for a few seconds or longer. And for a fruit fly whose larvae have only half the usual number of segments, there's fushi (Japanese for "segment of bamboo") tatazu ("not enough").
Finally, students of European history will appreciate Trudi Schupbach's work at Princeton University. Schupbach discovered several mutations that cause flies to bear sterile offspring. She named them after European royal familie with sterility problems -- such as Tudor, Valois and Vasa -- whose reigns were cut short for lack of heirs. And in an elegant twist, she gave the name staufen to one of the grandchildless mutants that has an additional inherited defect causing it to lack a proper head -- in memory of the infertile in·fer·tile
Not capable of initiating, sustaining, or supporting reproduction.
adj unable to produce offspring. Holy Roman Empire Holy Roman Empire, designation for the political entity that originated at the coronation as emperor (962) of the German king Otto I and endured until the renunciation (1806) of the imperial title by Francis II. family named Staufen whose last surviving member was ultimately beheaded be·head
tr.v. be·head·ed, be·head·ing, be·heads
To separate the head from; decapitate.
[Middle English biheden, from Old English beh .
Some fruit fly geneticists complain that younger researchers lack the imagination of their predecessors, and that the wild and woolly days of gene naming may be drawing to a close. In the past, says Grigliatti, "people were willing to poke fun at to make a butt of; to ridicule.
See also: Poke themselves. Now people have begun to name their genes with very serious names. People are much more conservative these days."
Kaufman concurs: "It's degenerating these days. The art is dying, I'm afraid."
Still, others say, there seems something about the field of fruit fly genetics that guarantees a continuing lineage of wackiness. Fruit fly research "bubbles with chaos," says Hall, nothing that compared to almost any other field of science, "there's very little orchestration."
Quinn agrees, but says the future of Thomas Morgans's legacy is ensured by more than that. The real reason that fruit fly nomenclatural inaneness remains secure, Quinn maintains, is that most fruit fly geneticists "are not very restrained by the bounds of good taste."
And with that in mind, this story will sidestep side·step
v. side·stepped, side·step·ping, side·steps
1. To step aside: sidestepped to make way for the runner.
2. any description of a rather peculiar mutant called tricky dick.