Human Genome Sciences obtains United States patent.
Human Genome Sciences, Inc. (Rockville, MD) and University of Michigan (Ann Arbor, MI) have patented Death Domain Containing Receptor-4 (DR4) proteins which are members of the tumor necrosis factor receptor family. In particular, isolated nucleic acid molecules are provided encoding the human DR4 proteins. DR4 polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same. The invention further relates to screening methods for identifying agonists and antagonists of DR4 activity. (US 6,943,020)