Aust Vet J.: Neuroangiostrongyliasis due to Angiostrongylus cantonensis in gang-gang cockatoos (Callocephalon fimbriatum).
Four gang-gang cockatoos from an aviary in Sydney displayed severe neurological signs. Three were necropsied, and histopathology of the brains and spinal cords revealed migrating nematodes, which were identified as Angiostrongylus cantonensis. The migrating larval nematodes created tracts of malacia in the brain, but elicited little inflammatory cell infiltration. However, adult nematodes that had emerged onto the meningeal surface of the spinal cord evoked a marked nonsuppurative reaction. Detailed histologic examination of other tissues revealed larvae embedded in arterioles in the gastrointestinal serosa, lung, and heart, which were associated with a significant granulomatous response. The latter lesions were consistent with our understanding of the pathogenesis of infection with this parasite, but have not been described previously, probably as a result of limited sampling. Angiostrongylus cantonensis still is present in the Sydney area and can cause significant disease in exposed animals, including birds. It also highlights potential human health problems.