Your Money: Stockwatch.
AMERICAN regulators have given drug giant GlaxoSmithKline a big headache.
Shares in the group fell 3.9 per cent as the US Food and Drug Administration warned it may limit sales of Glaxo's bestselling asthma treatment Advair.
The FDA is worried over potential side-effects and may recommend that Advair is only prescribed if other drugs fail to control the condition. Glaxo led the FTSE 100 fallers as the index fell back to earth after reaching a four-year high on Friday.
Vodafone slid 1.6 per cent despite last week's reassuring words about future growth from under-fire boss Arun Sarin. Some of the UK's best known high-street chains - Next, Dixons and Argos-owner GUS led the risers.
Next climbed 2.7 per cent as punters gambled on shoppers spending more money in the run-up to Christmas.
Dixons, now traded as DSG International, rose 1.9 per cent and GUS climbed 1.6 per cent. BP ended the day 1.5 per cent higher on news that it may buy a stake in Chinese jet fuel importer China Aviation Oil.
Elsewhere, computer services specialist Computacenter soared 23.3 per cent following Friday's announcement of a possible takeover by management.
And hopes of a lucrative takeover bid by WPP and French financier Vincent Bollore pushed advertising firm Aegis 5.6 per cent higher.