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Yeast or human, this gene's the same.

Yeast or human, this gene's the same

In a discovery that could influence laboratory research onhuman cell growth, scientists in London have cloned human genetic material they say is essentially the same as a gene in yeast that controls cell reproduction. The gene, called cdc2 in the yeast Schizosaccharomyces pombe, is important in regulating the microorganism's cell cycle, and its counterpart in humans may play a similar role, say Melanie G. Lee and Paul Nurse of the Cell Cycle Control Laboratory at the Imperial Cancer Research Fund facility.

By inserting segments from a "library' of human DNA intoyeast cells lacking active cdc2 genes, the researchers isolated human genetic material that could substitute for cdc2 and initiate cell division in the cdc2-deficient yeast cells. Lee and Nurse report in the May 7 NATURE that the human gene has been sequenced, and its structure is very similar to that of the cdc2gene. The authors say the S. pombe system can be used for isolating other genes that resemble those found in the yeast.
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Title Annotation:gene that controls cell reproduction
Publication:Science News
Date:May 16, 1987
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