When to worry about incidental renal and adrenal masses.
CASE * Jane C, a 76-year-old patient, reports lower abdominal discomfort and increased bowel movements. Her left lower quadrant is tender to palpation, without signs of a surgical abdomen, and vital signs are normal. Laboratory studies are also normal, except for mild anemia and a positive fecal occult blood test. Abdominal and pelvic computed tomography (CT), with and without contrast, are negative for acute pathology, but a 1.7-cm lesion is found in the upper pole of the left kidney. What is your next step?
Renal or adrenal masses may be discovered during imaging studies for complaints unrelated to the kidneys or adrenals. Detection of incidentalomas has increased dramatically, keeping pace with the growing use of ultrasonography, CT, and magnetic resonance imaging (MRI) for abdominal, chest, and back complaints. (1)
Family physicians can evaluate most of these masses and determine the need for referral by using clinical judgment, appropriate imaging studies, and screening laboratory tests. In the pages that follow, we present a systematic approach for evaluating these incidentalomas and determining when consultation or referral is needed.
Incidental renal masses are common
Lesions are commonly found in normal kidneys, and the incidence increases with age. Approximately one-third of individuals age 50 and older will have at least one renal cyst on CT. (2)
Most incidental renal masses are benign cysts requiring no further evaluation. Other possibilities include indeterminate or malignant cysts or solid masses, which may be malignant or benign. Inflammatory renal lesions from infection, infarction, or trauma also occur, but these tend to be symptomatic and are rarely found incidentally.
Classification of renal cysts--not based on size
Cysts are the most common adult renal masses. Typically they are unilocular and located in the renal cortex, frequently extending to the renal surface. (3) Renal function is usually preserved, regardless of the cyst's location or size. Careful examination of adjacent tissue is essential, as secondary cysts may form when solid tumors obstruct tubules of normal parenchyma. Cystic lesions containing enhancing soft tissue unattached to the wall or septa likely are malignant. (4)
The Bosniak classification system, with 5 classes based on CT characteristics (TASTE 1), is a useful guide for managing renal cystic lesions. (4) Size is not an important feature in the Bosniak system; small cysts may be malignant and larger ones benign. Small cysts may grow into larger benign lesions, occasionally causing flank or abdominal pain, palpable masses, or hematuria.
* Simple cysts. Renal cysts that meet Bosniak class I criteria can be confidently labeled benign and need no further evaluation (FIGURE 1). Simple renal cysts on CT have homogenous low-attenuating fluid and thin nonenhancing walls without septa. (4)
On ultrasound, simple renal cysts show spherical or ovoid shape without internal echoes, a thin smooth wall separate from the surrounding parenchyma, and posterior wall enhancement caused by increased transmission through the water-filled cyst. The likelihood of malignancy is extremely low in a renal cyst that meets these criteria, which have a reported accuracy of 98% to 100%. (3) Thus, no further evaluation is required if an obviously benign simple cyst is first noted on an adequate ultrasound. Inadequate ultrasound visualization or evidence of calcifications, septa, or multiple chambers calls for prompt renal CT.
CASE * The mass on Ms. C's left kidney is hypoattenuating and nonenhancing on CT. It meets Bosniak criteria for a benign simple cyst (class I) and requires no further evaluation or follow-up. Colonoscopy detects multiple colonic polyps that are removed, and the patient does well.
* Mildly complicated cysts. Less diagnostic certainty characterizes cysts with mild abnormalities that keep them from being labeled as simple. Bosniak classes II and IIF describe mildly abnormal renal cysts. Class II cysts can be dismissed, whereas class IIF cysts require follow-up.
Class II cysts may contain a few hairline septa, fine calcium deposits in walls or septa, or an unmeasurable enhancement of the walls. A hyperattenuating but nonenhancing fluid also is described as category II. Small homogeneous cysts <3 cm, without enhancement but hyperattenuated, are reliably considered benign and need not be evaluated. (2,7)
Class IIF cysts may have multiple hairline-thin septa with unmeasurable enhancement or minimal smooth thickening or irregular/nodular calcifications of wall or septa without enhancing soft tissue components. Hyperattenuating cystic lesions >3 cm and intrarenal "noncortical" cysts are included in this category. Class IIF cysts require follow-up at 6 months with CT or MRI, then annually for at least 5 years. (8)
* Obviously complicated cysts. Bosniak class III is indeterminate--neither benign nor clearly malignant. Class III cysts may have thickened borders or septa with measurable enhancement, or they may be multilocular, hemorrhagic, or infected. In 5 case series, 29 of 57 class III lesions proved to be malignant. (5) MRI may characterize these lesions more definitively than CT prior to urologic referral.
* Malignant cysts. Bosniak class IV renal lesions are clearly malignant, with large heterogeneous cysts or necrotic components, shaggy thickened walls, or enhancing soft tissue components separate from the wall or septa. Their unequivocal appearance results from solid tumor necrosis and liquefaction. Diagnosis is straightforward, and excision is indicated. (2)
A closer look at solid renal masses
Solid renal masses usually consist of enhancing tissue with little or no fluid. The goal of evaluation is to exclude malignancies, such as renal cell cancer, lymphomas, sarcomas, or metastasis. Benign solid masses include renal adenomas, angiomyolipomas, and oncocytomas, among others.
Several lesions can be diagnosed by appearance or symptoms:
* Angiomyolipomas are recognized by their fat content within a noncalcified mass. Unenhanced CT usually is sufficient for diagnosis, unless the mass is very small or has atypical features. (9)
* Vascular lesions can be identified because they enhance to the same degree as the vasculature. With the exception of inflammatory or vascular abnormalities, all enhancing lesions that do not contain fat should be presumed to be malignant.
In patients with a known extrarenal primary malignancy, 50% to 85% of incidental solid renal masses will represent metastatic disease. (10) Percutaneous biopsy may be warranted to differentiate metastatic lesions from a secondary, primary (ie, renal cell carcinoma), or benign process. (11)
A study of 2770 solid renal mass excisions revealed that 12.8% were benign, with a direct relationship between malignancy and size. Masses <1 cm were benign 44% of the time. (12) Early identification of small renal carcinomas may improve survival rates. Although renal cell carcinomas <3 cm in diameter have low metastatic potential, a solid, nonfat-containing mass should be evaluated for aggressive nephron-sparing surgery. (6,13)
Incidental adrenal masses occur infrequently
Adrenal incidentalomas are defined as radiographically identified masses >1 cm in diameter. (14) They are much less common than their renal counterparts, with a reported prevalence of 0.35% to 5% on CT. (15) Because the adrenal glands are hormonally active and receive substantial blood flow, metastatic, hormonally active, and nonfunctional causes for adrenal masses need to be considered. (16)
Adrenal masses may be characterized by increased or normal adrenal function. Hyperfunctioning syndromes include hypercortisolism, hyperaldosteronism, adrenogenital hypersecretion of adrenocortical origin, and pheochromocytomas of the medulla. Symptom evaluation of these syndromes is important, but not sufficient to rule out a hyperfunctioning syndrome.
In a retrospective review of in-apparent adrenal masses, [less than or equal to] 13% of pheochromocytomas were clinically silent. (17) Therefore, laboratory testing is necessary for an incidental adrenal mass.
* Nonfunctional lesions include adenomas, metastases, cysts, myelolipomas, hemorrhage, and adrenal carcinomas. These masses require evaluation for the possibility of cancer, the most common of which is metastasis. In patients with an extra-adrenal malignancy, the likelihood of malignancy in an incidental adrenal mass is at least 50%. (18) An adrenal mass representing metastasis of a previously unrecognized cancer is exceedingly rare. (19)
* Primary adrenal carcinoma is also rare, with an estimated incidence of 2 cases per one million in the general population. For patients with adrenal masses, the prevalence of carcinoma increases with lesion size (2% for tumors <4 cm, 6% for tumors 4-6 cm, and 25% for tumors >6 cm in diameter). (17) For this reason, tumors >4 cm in diameter are usually surgically resected in patients with no previous cancer history, unless radiologic criteria demonstrate clearly benign characteristics.
Although adrenal carcinomas are considered nonfunctioning, some evidence suggests they produce low levels of cortisol that may be associated with clinical features of metabolic syndrome. (20)
CT is first choice for adrenal mass evaluation
Dedicated adrenal CT with both unenhanced and delayed contrast-enhanced images is the most reliable study to evaluate an adrenal mass, according to the American College of Radiology. Consider another study only in patients with contrast allergy, renal compromise, or cancer history. (21)
Unenhanced CT can diagnose the approximately 70% of adenomas that are small, well-defined round masses with homogenous low-density lipid deposition. (22) Delayed contrast enhancement can characterize most of the remaining 30%. (23) Unenhanced CT with attenuation values of < 10 Hounsfield units (HU) can diagnose adenomas with 71% specificity and 98% sensitivity, (24) and can often diagnose simple cysts and myelolipomas, as well.
* Other imaging options. MRI is an alternative to CT for patients with contraindications for contrast or radiation exposure. MRI provides less spatial resolution than CT, but chemical shift imaging can measure cytoplasmic lipid content similar to unenhanced CT. A small study found chemical shift MR/ more reliable than unenhanced CT, but less reliable than CT with delayed contrast enhancement. (25)
Positron emission tomography (PET) is useful to noninvasively evaluate biochemical and physiologic processes. PET-CT incorporates unenhanced CT density measurements to improve PET accuracy. In a patient with a history of cancer, PET-CT has a sensitivity of 93% to 100% and a specificity of 95% in differentiating benign from malignant adrenal tumors. (26)
When to order a biopsy
The need for biopsy has decreased as imaging has improved, but biopsy is required whenever diagnostic imaging fails to differentiate a lesion as benign or malignant. CT-guided biopsy provides diagnostic accuracy of 85% to 95%. (27) Complications such as pneumothorax, hemorrhage, and bacteremia occur in 3% to 9% of biopsies. Before any adrenal biopsy, measure plasma-free metanephrines to exclude undiagnosed pheochromocytoma, which could precipitate a hypertensive crisis if untreated. (22)
These 3 laboratory screening tests are critical
Family physicians can perform the initial biochemical evaluation of an adrenal incidentaloma. Guidance is available from the National Institutes of Health (NIH) (28) and the American Academy of Clinical Endocrinologists (AACE) (FIGURE 2). (29)
Regardless of signs or symptoms, perform screening laboratory tests for 3 types of adrenal hyperfunction: hypercortisolism, hyperaldosteronism, and hypersecretion of catecholamines (pheochromocytoma). Screening tests are not recommended for androgen hypersecretion, which is extremely rare and causes recognizable symptoms such as hirsutism (TABLE 2). (29)
* Hypercortisolism occurs in approximately 5% of adrenal incidentalomas. (30) An overnight dexamethasone suppression test (DST) is most reliable for screening, with sensitivity >95% for Cushing syndrome. (31) The patient takes a 1-mg dose of oral dexamethasone at 11 pm, and a fasting plasma cortisol sample is drawn the next day at 8 am.
Dexamethasone binds to glucocorticoid receptors in the pituitary gland, suppressing adrenocorticotropic hormone secretion. Cortisol will be depressed the next morning unless the adrenal mass produces cortisol autonomously. Patients with a DST >5 mcg/dL--highly suggestive of Cushing syndrome--require further evaluation, and we suggest referral to an endocrinologist.
* Hyperaldosteronism is seen in 1% to 2% of adrenal incidentalomas. (32) The aldosterone-to-renin ratio (ARR) is recommended as a screening test for hyperaldosteronism, with an ARR >20 requiring further testing. (33) Medications that may affect the ARR include beta-blockers, spironolactone, clonidine, diuretics, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers. (29)
Refer a patient with evidence of hyperaldosteronism to an endocrinologist and a surgeon with experience in managing these lesions. If the ARR test result suggests an aldosterone excess, a salt-loading test is used to verify failure of aldosterone suppression. Adrenal venous sampling is often performed prior to surgical removal to confirm that an incidentaloma is the source of hyperaldosteronism.
* Pheochromocytoma. Approximately 5% of incidental adrenal lesions are pheochromocytomas. (30) Many patients with these epineph rine/norepinephrine-secreting tumors do not show the classic symptom triad of headache, palpitations, and diaphoresis, and approximately half have normal blood pressure. (34)
Identifying a pheochromocytoma is important in any patient requiring surgery or biopsy, as surgical manipulation can cause a potentially fatal intraoperative catecholamine surge. Presurgical medical management can mitigate this reaction.
A plasma-free metanephrines test, which has 95% sensitivity, is the most reliable test for pheochromocytoma. (35) Medications, including tricyclic antidepressants, decongestants, amphetamines, reserpine, and phenoxybenzamine, can cause false-positive results. (29) Confirm a positive plasma-free metanephrines test with a 24-hour fractionated urine metanephrines test, and refer the patient to an endocrinologist.
Managing adrenal incidentalomas
Refer all patients with adrenal masses >4 cm for surgical evaluation because of the risk of malignancy; all patients who have a history of malignancy and an adrenal mass of any size require a referral to an oncologist. Perform the AACE-recommended 3-element biochemical workup for all masses, with the exception of definitively diagnosed cysts or myelolipomas.
Refer to an endocrinologist all patients with abnormal screening laboratory results, regardless of adrenal mass size, as well as patients with concerning clinical findings. Initiate cardiovascular, diabetes, and bone density evaluation and management for metabolic syndrome. (20)
Monitoring after a negative workup
Little evidence exists to guide monitoring of small adrenal incidentalomas (<4 cm) with a negative workup. The 2002 NIH report recommended annual radiologic follow-up for 5 years, (28) whereas the 2009 AACE guidelines recommend radiographic follow-up at 3 to 6 months, then at one and 2 years. (29)
Evidence indicates that 14% of lesions will enlarge in 2 years, although the clinical significance of enlargement is unknown. Some authors argue against CT monitoring because the risk of adrenal mass progression is similar to the malignancy risk posed by 3 years of radiation exposure with CT. (20)
Some guidelines recommend repeat biochemical screening every 3 to 4 years. (28,29) AACE guidelines quote a 47% rate of progression over 3 years, but most adrenal masses progress to subclinical Cushing syndrome--a condition of uncertain significance. Subclinical Cushing's has not been reported to progress to the overt syndrome, and new catecholamine or aldosterone secretion is rare.
Many endocrinologists reduce the frequency of follow-up, depending on the type of adrenal mass (cyst or solid) and its size. AACE suggests CT for adenomas one to 4 cm at 12 months. AACE and NIH recommend hormonal evaluation annually for 4 years. Adrenal cysts or myelolipoma in patients without cancer need no follow-up. (29)
* Use computed tomography studies and the Bosniak classification system to guide management of renal cystic masses. (A)
* Perform laboratory tests for hypercortisolism, hyperaldosteronism, and hypersecretion of catecholamines (pheochromocytoma) on any patient with an incidental adrenal mass, regardless of signs or symptoms. (c)
* Refer patients with adrenal masses >4 cm for surgical evaluation. Refer any individual who has a history of malignancy and an adrenal mass for oncologic evaluation. (B)
Strength of recommendation (SOR)
(A) Good-quality patient-oriented evidence
(B) Inconsistent or limited-quality patient-oriented evidence
(C) Consensus, usual practice, opinion, disease-oriented evidence, case series
What would you say to a patient considering genetic analysis?
* It may yield incidental findings about unmodifiable risks best left unknown
* It could be the impetus to lead a healthier lifestyle
* It is unnecessary in most cases
* do not recommend it
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James C. Higgins, DO, CAPT, MC, USN, Ret; Michael J. Arnold, MD, LCDR, MC, USN Family Medicine Department, Naval Hospital, Jacksonville, Fie (Dr. Higgins); Branch Health Clinic Capodichino, Naval Hospital, Naples, Italy (Dr. Arnold)
The authors reported no potential conflict of interest relevant to this article.
The opinions and assertions contained herein are the private views of the authors and are not to be construed as official, or as reflecting the views of the US Naval Medical Service or the US Navy at large.
James C. Higgins, DO, CAPT, MC, USN, Ret., Naval Hospital Jacksonville, Family Medicine Department, 2080 Child Street, Box 1000, Jacksonville, FL 32214; James.firstname.lastname@example.org
TABLE 1 In the Bosniak system, CT results guide incidental renal cyst management (1,2,4-6) Category Imaging features Class I Low-attenuating (0-20 HU) fluid; hairline-thin Simple cyst, smooth wall without septa, calcifications, or benign enhancing soft tissue Class II Single or few thin (<1 mm) septa; may be minimally Minimally calcified; perceived but no measurable enhancement; complex cyst, includes high-attenuating (>20 HU) cysts probably benign <3 cm that are well marginated, homogeneous, and nonenhancing Class IIF Thin walls may contain multiple thin septa; may have Moderately smooth, minimally thickened wall or septa, with complicated irregular or nodular calcifications or perceived but cyst, probably no measurable enhancement or soft tissue enhance benign but ment; includes hyperdense completely intrarenal requires cysts >3 cm with no enhancement follow-up Class III Thickened irregular or smooth walls or septa with Indeterminate measurable enhancement renal lesion Class IV Contains enhancing soft tissue components Presumed adjacent/separate from wall or septa malignant cystic mass Likelihood Category Clinical management of malignancy Class I Renal CT if symptoms 0%-1.7% Simple cyst, occur benign Class II Renal CT if symptoms 0%-14% Minimally occur complex cyst, probably benign Class IIF Renal CT at 6 and 18%-25% Moderately 12 months, then complicated annually for 5 years cyst, probably benign but requires follow-up Class III Renal CT/MRI and 33%-60% Indeterminate referral for surgical renal lesion evaluation Class IV Renal CT/MRI and 67%-100% Presumed referral for surgical malignant evaluation cystic mass CT, computed tomography; HU, Hounsfield units, a density measurement; MRI, magnetic resonance imaging. TABLE 2 Incidental adrenal masses: Symptoms that suggest pathology (29) Consider this pathology ... in patients with ... Hypercortisolism Fatigue, depression, menstrual irregularities, hypertension, easy bruising, fracture with minimal trauma Hyperaldosteronism Muscle cramping, weakness, headaches, intermittent or periodic paralysis, fluid retention, polydipsia, polyuria Pheochromocytoma Palpitations, anxiety attacks, weight loss, sweating, syncope or near syncope Hyperandrogenism Hirsutism, acne, loss of scalp hair, increased muscle bulk, deepening of voice Carcinoma or Weight loss, abdominal or flank pain, metastatic disease fever
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|Author:||Higgins, James C.; Arnold, Michael J.|
|Publication:||Journal of Family Practice|
|Article Type:||Case overview|
|Date:||Sep 1, 2013|
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