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Wellmune WGP may reduce URTI symptoms and improve mood.

In a study of 122 healthy volunteers (32 men/90 women), participants taking 250 mg of Biothera's Wellmune WGP daily for 12 weeks reported a statistically significant (58%) reduction in upper respiratory tract infection (URTI) symptoms, compared with individuals taking a placebo.

Using a Profile of Mood States (POMS) psychological survey to assess changes in mental and physical energy levels and overall well-being, the study demonstrated statistically significant benefits for the Wellmune WGP group. These participants rated their overall well-being and vigor 9.5% and 11% higher, respectively, compared with the placebo group.

GLH Nutrition, which conducted the study on behalf of Biothera, is an independent research and development organization that evaluates ingredients for food, beverage and dietary supplements. For further information: www.wellmune.com

MaitakeGold 404 Provides Safe & Effective Immune Support

A new clinical trial has confirmed the immune-enhancing properties of MaitakeGold 404, a multi-patented nutraceutical ingredient from the TradeWorks Group. MaitakeGold 404 is a proprietary extract of Maitake mushroom (Grifola frondosa).

A three-year, U.S. Government-funded, multi-phase, human clinical study of MaitakeGold 404's immune-enhancing properties was initiated at Memorial Sloan-Kettering Hospital. In conjunction with this research, MaitakeGold 404 received an IND (Investigational New Drug) number.

In a Phase I/II trial, 34 subjects took MaitakeGold 404 at varying doses for three weeks. Researchers discovered that balanced immune support (immunomodulation) occurred in subjects at all dosage levels (including low doses), with no adverse effects or toxicity. After three weeks, T-cell activity increased, as did levels of immune-enhancing cytokines (IL-2, TNF-a, IFN-Y), and anti-inflammatory cytokines (IL-10).

According to researchers, this study demonstrates that MaitakeGold 404 is highly bioavailable while being safe to use when taken orally on a daily basis. In addition, this proprietary mushroom extract is effective in supporting immunity while limiting inflammation that can be associated with a healthy immune response. For further information: www.maitakegold.com

Genistein (geniVida) Ameliorates Artificially Induced Dry Eye in Rats

A new study conducted at Salus University was presented at the Association for Research in Vision and Ophthalmology meeting in Fort Lauderdale recently, suggesting that the isoflavone genistein may restore tear production that is diminished in dry eye syndrome.

Authors W. Schalch, F. Roos and F. Barker artificially induced dry eye syndrome in female Sprague-Dawley rats through daily trans-dermal treatment with scopolamine. The animals were maintained on diets containing 0, 50 and 250 parts per million (ppm) of the isoflavone genistein (geniVida from DSM Nutritional Products) for 4 weeks. Another group received no scopolamine or genistein to serve as the control. The animals on 0 ppm genistein experienced a drastic reduction in tear volume and goblet cell density. Animals given genistein at 50 or 250 ppm had significantly improved tear volume and goblet cell density to values in the range of the non-treated controls. Plasma levels of genistein in the treated animals were in the range seen in human studies and thus have practical application. For further information: www.dsmnutritionalproducts.com

Study Detects Nattokinase Bioavailability in Human Serum

Scientists have been able to discern and document the bioavailability of nattokinase in human serum, according to a new study titled "Oral Bioavailability of Nattokinase (NSK-SD)."

Researchers, in conjunction with the San Francisco General Hospital Department of Hematology, gave 11 healthy subjects, aged 21 to 65, a single daily dose (2000 FU) in soft gel capsules, providing 100 mg of purified nattokinase (NSK-SD) from Japan Bio Science Laboratory. Each volunteer was subject to blood draws at 0, 2, 4, 8, 12, 24 and 48 hours post ingestion of the supplement; blood draws were measured by ELISA using a rabbit polyclonal anti-nattokinase capture antibody.

The researchers observed a pharmacokinetic pattern for NSKSO between baseline and 48 hours post-dose, peaking at approximately 13.3 hours post-dose. Statistically significant increases in detectable serum nattokinase from baseline were documented at 2 and 24 hours. For further information: www.jbsl-net.com/english

MicroActive CoQ10 Universally Bioavailable

A new study on MicroActive CoQ10, a patented form of CoQ10--which is manufactured by BioActives LLC and distributed by Maypro Industries--found that 100% of subjects taking MicroActive CoQ10 levels after three weeks of supplementation, compared to just 44% of subjects taking oil-solubilized CoQ10 soft gels. Results were published in the journal Integrative Medicine.

The study included an acute phase (0-24 hours, single dose of 180 mg) and an accumulation phase (21 days, daily dose of 60 mg). During the acute phase, five healthy subjects ingested either: MicroActive CoQ10 hard gelatin capsules, crystalline CoQ10 hard gelatin capsules or oil-solubilized CoQ10 soft gels containing a proprietary absorption enhancer. The study was crossover in design, so all subjects tested all formulations. During the accumulation phase, 22 healthy subjects were randomly divided into two groups: Group A, assigned MicroActive CoQ10 hard gelatin capsules, and Group B, assigned oil-solubilized CoGTO soft gels containing a proprietary absorption enhancer.

The results of the acute phase showed that both the MicroActive and the solubilized CoQ10 had significantly better bioavailability than the regular crystalline powder. However, the inter-subject variance was significantly greater in the group taking the solubilized form versus the other two. Additionally, the MicroActive CoQ10 complex showed a sustained release.

The results of the accumulation phase demonstrated that the MicroActive group showed higher uptake of CoQ10 compared with the solubilized group. In fact, while 100% of subjects in the MicroActive group doubled their CoQ10 levels after three weeks, only 44% of those in the solubilized group did so. For further information: www.maypro.com

Increased Quantities of Hi-maize Boost Satiety

New research published in the American Journal of Clinical Nutrition has indicated that the quantity of resistant starch in foods correlates with blood glucose response and reduced food intake after two hours.

A University of Toronto research team, led by G. Harvey Anderson, PhD, also found that Hi-maize whole grain corn flour and Hi-maize resistant starch, from National Starch Food Innovation, increased satiety and reduced food intake after two hours. This randomized, crossover, two-part study investigated the short-term effects of consuming Hi-maize whole grain corn flour and Hi-maize resistant starch in a group of healthy men, aged 20-30 years.

After consuming a standard breakfast, participants consumed one of five soups--three soups contained 50 grams of added starch-based ingredients while two soups served as controls. Fifty grams of maltodextrin in one soup served as a high glycemic control and another soup containing no additional carbohydrate ingredients served as a low-calorie control. Glycemic response, subjective satiety and subsequent food intake (with participants instructed to eat until they were comfortably full) information was collected after a defined period of time. Each treatment was separated by a one-week washout period.

Sixteen men participated in part one of the study, which collected the glycemic and satiety responses at 30 minutes after consumption of the test soups. The study found that the high glycemic control boosted satiety at 30 minutes, but did not reduce cumulative food intake. Ingredients with high resistant starch content had no effect on satiety or food intake at 30 minutes.

Seventeen men participated in part two of the study, which collected glycemic and satiety responses at two hours after consumption of the test soups. At two hours, resistant starch correlated with satiety and reduced food intake. Ingredients with the highest levels of resistant starch had the most pronounced effect. Hi-maize whole grain corn flour had the highest resistant starch content (66%) and reduced cumulative food intake by 15% (244 kilocalories) compared to the high glycemic control. Hi-maize 260 (48% resistant starch) reduced food intake by 7% (116 kilocalories), and uncooked cornstarch (39% resistant starch) reduced food intake by 7% (113 kilocalories), also compared to the high glycemic control. All of the soups containing resistant starch (including the ones with low dietary fiber) reduced food intake at 2 hours. For further information: www.foodinnovation.com

Nutricosmetic Supplement Protects Skin and Reduces Wrinkling

Daily oral supplementation with Lyc-O-Mato, a natural lycopene complex extracted from red ripe tomatoes from LycoRed Corp, enhanced the protective properties of the skin against environmental stress and reduced premature aging and wrinkles, according to a new study conducted by dermatologist Zoe Diana Draelos, MD.

In the 10-week study, one group supplemented daily with Lyc-O-Mato capsules and the second group supplemented with a placebo (soy oil). After the supplementation period, subjects were exposed to two MEDs of UVB and UVA radiation. Skin biopsies taken from the volunteers were analyzed to determine the number of sunburn cells formed after the exposure to radiation. Sunburn cells are dead cells, indicative of DNA damage caused by UVB and UVA light. The number of sunburn cells found for the Lyc-O-Mato group was significantly lower as compared to the number found for the placebo control group. Fewer sunburn cells indicate less skin damage, which can manifest itself as premature aging and wrinkles. For further information: www.lycored.com

Chirositol Shows Positive Effects on Hyperglycmia in Rats

Results from a recent in vivo study published in the June issue of Current Bioactive Compounds showed that three-week administration of Chirositol (95% D-Chiro-Inositol), from Cyvex Nutrition, alone and in combination with manganese sulfate, significantly reduced blood glucose levels in diabetic mellitus-induced rats.

Results showed that a 12-day oral administration of Chirositol decreased blood glucose levels by a combined 23% when compared to the control group, while administration of both Chirositol and manganese sulfate resulted in a combined 40% decrease during the same time period. Also of note was the decrease in overall body weight of both male and female rats receiving Chirositol and manganese sulfate, with females exhibiting a 25% body weight decrease over the control group, and males 21 % as measured during the 21-day study period. For further information: www.cyvex.com

Protein Blends Optimal for Sports Performance

Consuming a blend of proteins (isolated soy protein, whey protein and casein) may have advantages for sports performance and provide nutritional advantages over consuming just one type of protein, according to a review by Dr. Greg Paul, global director of sports nutrition, Solae, which was published in a supplement accompanying the Journal of the American College of Nutrition.

The review is titled "The Rationale for Consuming Protein Blends in Sports Nutrition." Dr. Paul said of the study, "My review proves not only the importance of protein, but also potential benefits of combining different proteins, particularly to help promote recovery after exercise activity."

According to FDA labeling guidelines, isolated soy protein, whey protein and casein are all nutritionally complete proteins. However, all three proteins differ in digestion rates, potentially creating a "timed-release" effect that could prolong the time that absorbed amino acids are delivered to muscle resulting in faster recovery. Additionally, comparative studies between isolated soy protein and whey protein may have an advantage over casein. For further information: www.solae.com

Red Microalgae Cosmetic Ingredient Protects Skin

Results of a new clinical study show that Alguard, an all-natural cosmetic ingredient developed by Frutarom Ltd, provides immediate beauty enhancement when applied to the skin.

Alguard is known for its ability to provide long-term protection to skin, but this study is the first to demonstrate it can also offer skin enhancement immediately after the first usage. Following the encouraging results, Frutarom has released a preservative free eco-certified version of Alguard.

In this study, conducted by the Israeli Skin Research Institute, 10 women applied a small amount of Alguard on half of their faces compared to a control cream on the other half and were monitored for one hour in a controlled environment. A clear reduction in fine-line length and depth, as well as a 24% average reduction in skin roughness were observed.

Alguard is derived from a polysaccharide surrounding red microalgae adapted to the extreme conditions of the ocean tidal zone. This polysaccharide is the survival secret of the red microalgae. It forms a protective layer, shielding the algae from harsh elements. Alguard forms a similar protective layer, or "active shield," when applied to the skin.

Alguard is produced by an all-natural physical purification process and is standardized according to its polysaccharide content. For further information: www.frutarom.com

Aminogen Shows Promise for New Cardiovascular Applications.

New clinical findings suggest Aminogen, the patented enzyme system from Triarco Industries, may help support measures of cardiovascular health, such as cholesterol and triglyceride levels. An earlier clinical study, published in the Journal of the International Society of Sports Nutrition, found that Aminogen significantly lowered C-reactive protein (CRP), an indication of cardiovascular inflammation, by 10%.

The double-blind, randomized trial matched 40 healthy men, aged 18-45, according to body weight, age and resistance training and divided them into two groups. The first group was given 100 grams of whey protein four times each week. The second group received 100 grams of whey protein with 3 grams of Aminogen four times each week. Cholesterol and triglyceride levels were checked at the onset of the study and again after four weeks.

The results show that the two groups experienced significantly different changes in LDL and total cholesterol. The group not taking Aminogen had an increase in LDL of almost 19% and a decrease in HDL of 12%, whereas the group taking Aminogen had a decrease in LDL of nearly 2% and an increase in HDL of 2%. Triglyceride levels also increased more than 3% in the group not taking Aminogen. For further information: www.aminogen.com

Probiotic Treatment Relieves IBS Symptoms.

Four-week treatment with the probiotic strain Lactobacillus plantarum 299v (Lp299v) effectively relieves gastrointestinal symptoms, particularly abdominal pain and bloating, in Irritable Bowel Syndrome (IBS) patients fulfilling the Rome III criteria, according to a study presented at Digestive Disease Week (DDW) by Professor Philippe Ducrotte, from Rouen University Hospital, in France.

This randomized, placebo-controlled trial, conducted over a 4-week period, involved 214 patients (63 women and 151 men), who fulfilled the Rome III criteria for IBS. The treatment consisted of a daily capsule of placebo or Lp299v (from Institut Rosell-Lallemand), equivalent to 1010 CFU/day. IBS symptoms were monitored (frequency and intensity of abdominal pain, bloating, number of stools, feeling of incomplete rectal evacuation).

After four weeks, Lp299v significantly improved the symptoms, in particular abdominal pain and bloating, as compared to both baseline and the placebo group. The overall patients' assessment of the treatment efficacy was significantly better in the Lp299v group compared to the placebo group. For further information: www.institut-rosell-lallemand.com

Mirtogenol Lowers Intraocular Pressure & Improves Blood Flow.

A study published in the May issue of Clinical Ophthalmology reveals Mirtogenol, taken with Latanoprost medication, effectively improves blood flow to the eyes in patients with ocular hypertension and aids in further normalizing ocular pressure.

Subjects underwent complete eye exams, which found no signs of primary open angle glaucoma or visual field defects. Subjects were randomly divided into three groups to receive treatments of prescription eye drop medication Latanoprost, Mirtogenol tablets, or a combination of both. Each Mirtogenol tablet contains 40 mg of Pycnogenol and 80 mg of Mirtoselect. Subjects consumed one Mirtogenol tablet once in the morning. Latanoprost was taken as one drop per eye daily in the evening. The patients' intraocular pressure was measured at the same time in the morning at each visit.

Normal eye pressure ranges from 10-21 mmHg. Ocular hypertension begins at a level greater than 21 mmHg. In the group of subjects taking Mirtogenol alone, the intraocular pressure was lowered from 38 to 29 mmHg, whereas in those taking Latanoprost the intraocular pressure decreased from 38 to 27 mmHg. In the third group of patients who took a combination of Mirtogenol and Latanoprost, the intraocular pressure decreased from 38 to 23 mmHg. The study concluded that the combination of Mirtogenol and Latanoprost was more effective than each constituent alone for lowering intraocular pressure, and also yielded better retinal blood flow.

Mirtogenol, a trademark of Indena S.p.A and Horphag Research Ltd., is a patent-pending, proprietary combination of the standardized bilberry extract Mirtoselect and the French maritime pine bark extract Pycnogenol. For further information: www.mirtogenol.com

Diabetinol Impacts Glycemic Control.

Two studies recently published by the Journal of Functional Foods, sponsored by KGK Synergize Inc., evaluated the safety and efficacy of Diabetinol, a proprietary ingredient, in both an in vivo and a human clinical study. The results of the in vivo study demonstrated that Diabetinol did not produce any adverse effects in a fructose-induced hamster model and showed improvement in blood glucose, insulin, cholesterol and triglycerides.

In a human clinical study conducted by SIBR Research Inc., researchers demonstrated that the use of Diabetinol over a three-month period was safe and effective in significantly reducing glucose intolerance in subjects with impaired fasting glucose (IFG), who were also taking oral medication. Diabetinol significantly reduced total cholesterol and LDL cholesterol. Decreasing trends in HbA1c were also observed. Data suggest that Diabetinol as a natural food product may have protective effects in individuals with a combined IFG and hyperlipidemia.

For further information: www.kgksynergize.com

Probio'Stick Inhibits Signs of Depression Following Myocardial Infarction.

A new study involving Institut Rosell-Lallemand's probiotic Probio'Stick strengthens the idea of a role for the gut microflora and probiotics in the gut-brain axis, or gut-brain communication, indicating potential applications for probiotics in mental health and the management of stress and anxiety.

In this new study, the research team looked at the effects of the probiotic preparation Probio'Stick (Lactobacillus Rosell-52 and Bifidobacterium Rosell-175) on rats' behavioral signs of depression--using social interaction, forced swimming and passive avoidance tests--two weeks following induction of myocardial infarction. They also studied the effects of the probiotic on pro-inflammatory cytokine content as well as on the intestinal barrier integrity.

While rats on a controlled diet showed behavioral signs of depression, the probiotic treatment was able to significantly reduce these signs. Probio'Stick also prevented the post-MI increase of pro-inflammatory cytokine IL-1 [beta], which is one of the mechanisms involved in the onset of post-MI depression via induction of apoptosis, or programmed cell death, in certain parts of the brain.

Interestingly, this study also showed that myocardial infarction has a detrimental effect on the intestinal barrier and that the probiotic was able to restore its integrity. For further information: www.institut-rosell-lallemand.com
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Title Annotation:Research Highlights
Publication:Nutraceuticals World
Geographic Code:1USA
Date:Jul 1, 2010
Words:3001
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