Printer Friendly

Weight loss critical in diabetes management.

Overweight patients with type 2 diabetes should lose weight, rather than take ever-increasing doses of insulin, according to diabetes researcher, Roger H. Unger, MD.

In a commentary that appeared recently in the Journal of the American Medical Association, (1) Dr. Unger noted that the current paradigm regarding type 2 diabetes focuses on patients' high blood sugar levels, and involves treatments designed to reduce blood sugar, often through intensive insulin therapy. But insulin resistance and the failure of pancreatic beta cells to produce adequate insulin are the result of lipotoxicity, or fatty acid poisoning, according to a new view of the disease. (2)

Fat cells release substances that contribute to insulin resistance, including adiponectin, resistin, tumor necrosis factor-alpha, and interleukin-6. (3) The logical remedy is to reduce or remove the problem--excess body fat--rather than escalate insulin doses. High levels of insulin only contribute to the problem, says Dr. Unger, by shifting excess glucose to fatty acid production, thus increasing the fatty acids that cause diabetes in the first place.


(1.) Unger RH. Reinventing type 2 diabetes: pathogenesis, treatment, and prevention. JAMA. 2008 Mar 12;299(10):1185-7.

(2.) Carpentier AC. Postprandial fatty acid metabolism in the development of lipotoxicity and type 2 diabetes. Diabetes Metab. 2008 Apr;34(2):97-107.

(3.) Keller U. From obesity to diabetes. Int J Vitam Nutr Res. 2006 Jul;76(4):172-7.
COPYRIGHT 2008 LE Publications, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2008 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:IN THE NEWS
Author:Kiefer, Dale
Publication:Life Extension
Article Type:Brief article
Geographic Code:1USA
Date:Aug 1, 2008
Previous Article:Olive oil substance is excellent fish oil preservative, antioxidant.
Next Article:Fish oil improves infants' cognitive and motor function.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters