Printer Friendly

Vitamin relative may aid stroke repair. (Biomedicine).

Vitamin C can't pass through the so-called blood-brain barrier to gain entry into the brain, but its precursor, dehydroascorbic acid (DHA), can. Thanks to this trait, DHA might help stroke patients retain the use of endangered parts of their brains, a new study finds.

When a clot shuts off blood flow to part of the brain, patients sometimes receive powerful clot-busting drugs to reopen the blocked vessel. In other people, blood finds alternate routes to threatened areas. This resurgence of blood can't save brain cells that are dead, but it can salvage nearby tissue that faces a dwindling blood supply.

Meanwhile, blood flow shut-off and restoration both unleash free radicals--highly reactive molecules that disrupt cells and complicate the capability of the smallest blood vessels, called capillaries, to nourish tissue and keep it alive.

Antioxidants such as DHA and vitamin C neutralize free radicals. To assess their value in limiting stroke damage, David W. Golde of Memorial Sloan-Kettering Cancer Center in New York, and his colleagues experimented with mice. The researchers modeled strokes in people by shutting off blood flow to parts of the animals' brains and then restoring it in some mice.

The mice getting DHA infusions as much as 3 hours after an induced stroke preserved function in more of the brain than did mice getting vitamin C or an inert substance, the scientists report in the Sept. 25 PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES. Further testing is needed, but the work suggests that DHA might limit the brain area damaged by stroke, Golde says. --N.S.
COPYRIGHT 2001 Science Service, Inc.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2001, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Science News
Article Type:Brief Article
Date:Oct 13, 2001
Previous Article:Detecting cancer risk with a chip. (Biomedicine).
Next Article:Tiny detector finds hydrogen better. (Materials Science).

Related Articles
Passive smoking tied to vitamin C loss.
Vitamin C and diabetes: risky mix?
Stroke patients show dearth of vitamin D.
Protein may aid stroke recovery.
Vitamin C may treat cancer after all.
Overuse of antihypertensives in patients with acute ischemic stroke.
Mitochondrial encephalopathy, lactic acidosis and stroke-like syndrome (MELAS): a case report, presentation, and management.

Terms of use | Copyright © 2017 Farlex, Inc. | Feedback | For webmasters