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Vitamin Supplements Associated with Lower Risk of Pancreatic Cancer.

A meta-analysis found an association between higher vitamin intake and a lower risk of cancer of the pancreas. *

Ying Liu and colleagues selected 25 studies that included 1,214,995 subjects for their analysis. Studies included case-control investigations, randomized controlled trials, cohort studies, prospective studies and retrospective studies that provided data on the intake of vitamin A, B, C, D, or E. Pancreatic cancer cases totaled 8,740.

Subjects with the highest vitamin intake in the prospective studies had a 10% lower adjusted risk of developing pancreatic cancer compared to those among the lowest intake group. In retrospective studies, the risk was 21% lower for those whose vitamin intake was highest.

In a dose-response meta-analysis, intake of 10 mcg or more of vitamin B12 lowered the incidence of pancreatic cancer by 27%. For vitamin D, the risk was lowered by 25%.

Editor's Note: In their discussion, the authors list a number of mechanisms to explain the effects of vitamins on pancreatic cancer cells. As examples, vitamin E has been shown to induce cell-cycle arrest and apoptosis (programmed cell death) in human pancreatic cancer cells, and vitamin B1 has been shown to increase caspase-3 activity (involved in apoptosis) and decrease pancreatic cell proliferation.


* Medicine (Baltimore). 2018 Mar;97(13):e0114.

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Title Annotation:In The News
Publication:Life Extension
Article Type:Brief article
Date:Nov 1, 2018
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