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Vitamin C and multifactorial disease.

Even minor vitamin C deficiencies, as are present in one third of a "normal" population, may induce the deposition of cholesterol beneath the vascular endothelium and lead to atherosclerosis.

There is evidence that both vitamin C deficiency and stress will increase blood histamine levels (histaminemia). Such histaminemia causes separation, or disassociation, of endothelial cells lining the insides of our blood vessels. Scurvy occurs when there is also a profound deficiency of vitamin C, which weakens the collagen fibers surrounding the blood vessels.

I have reported my research that found results of blood analysis samples from 437 normal volunteers, both for vitamin C and for histamine. Not only were blood histamine levels found to be significantly elevated in 34% of the subjects who had lower vitamin C levels below 0.7 milligrams per deciliter (P.001), it was also found that the administration of 1 gram of vitamin C daily for 3 days to eleven people with histaminemia, caused a reduction in blood histamine levels in all eleven.

I have also observed increased blood histamine levels in twelve resident physicians who had worked all day and throughout the night with much sleep deprivation. Consequently, mean histamine levels were 12.7 nanograms per millimeter after a night of sleep and 29.0 nanograms per millimeter after a day and night on duty.

Resident physicians should not be required to work more than a twelve-hour shift. The present practice, in many institutions, to subject interns to as much as thirty-six hour tours of duty can be injurious to both the physician and the patient.

As a professor of obstetrics and gynecology, I have learned from extensive studies of a condition known as abruptio placentae (premature placental separation) and am convinced that our ancestors were correct in intuitively providing a diet for pregnant females with fresh fruits and vegetables and urging plentiful sleep.

The development of diabetes mellitus in patients with hemochromosis (a disorder of iron metabolism) and in patients with thalasemic major (an inherited anemia blood disorder) are clear indications of the proxidant effects of stored iron compounds.

These findings indicate the need for insoluble chelating fiber in food to draw excess heavy metals from the blood stream into the lumen of the bowel for excretion. Moreover, glutathione reductase is essential, so that reduced glutathione can reduce dehydroascorbic acid to ascorbic acid in the tissues of the body; so not only do we need an adequate ascorbic acid intake, we also need B vitamins and sulfhydryl amino acids to keep ascorbic acid in the reduced form.
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Author:Clemetson, C. Alan
Publication:Nutrition Health Review
Date:Mar 22, 1992
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