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Visual Axis Opacification after Congenital Cataract Surgery and Primary Intraocular Lens Implantation: Comparison of Three Different Lenses.

INTRODUCTION

Congenital and developmental cataracts are the most common treatable causes of childhood blindness (1, 2). With improvements in surgical techniques and intraocular lens (IOL) designs, primary implantation of IOLs for rehabilitation has become popular in recent years. However, implanting an IOL to pediatric eyes is still controversial because the eye globe continues to grow, and axial length and refractive values constantly change. Additionally, postoperative complications requiring secondary surgery frequently occur in younger children because of ocular inflammation during the postoperative period (3).

Visual axis opacification (VAO) is a major complication in pediatric cataract surgery. Several surgical techniques, such as posterior continuous curvilinear capsulorhexis (PCCC), anterior vitrectomy (AV), optic capture, and the bag-in-the-lens technique, can prevent this complication. However, these techniques have some limitations that still present a threat to clear visual axis because of excessive immune response and migration of lens epithelial cells (LEC) (4). Most surgeons prefer hydrophobic acrylic IOL for pediatric cataract surgery. Nevertheless, VAO has been performed with all types of IOL material (5). There are very few reports concerning the relationship between different IOLs and VAO in congenital cataract surgery with posterior capsulotomy and AV. We aim to report the VAO incidence in children who underwent cataract surgery with posterior capsulotomy, AV, and primary IOL implantation with three different IOLs.

METHODS

The parents of the children provided written informed consent approval of the ethics committee was received, and the study followed the principles of the Declaration of Helsinki. Our study is a retrospective study of 65 eyes of 49 children aged 24-96 months who underwent congenital and developmental cataract surgery at an older age in our hospital between 2006 and 2012. Preoperatively, all children had complete ophthalmic examination. In younger or uncooperative children, ocular examination was performed under general anesthesia. Eyes that had the poor red reflex were operated. The exclusion criteria were persistent hyperplastic primer vitreous, uveal inflammation or congenital glaucoma, microphthalmos, and coloboma. Children who did not complete 12 months follow-up were excluded from the study.

All surgeries were performed under general anesthesia by a surgeon. A clear 2.8 mm corneal incision was performed at 12 o'clock meridian. Anterior chamber was filled by sodium hyaluronate (3.0%), and a 4.0-5.0 mm anterior continuous curvilinear capsulorhexis was performed by using a capsulorhexis forceps. After cortical hydrodissection, lens material was aspirated. Then, viscoelastic material (1.4%) was injected into the capsular bag, and a PCCC approximately 3.5 mm was performed followed by AV and foldable IOL implantation into the bag. All incisions were closed by 10.0 nylon suture after intracameral antibiotic injection.

Postoperatively, children received topical steroid and antibiotic drops eight times a day, which were tapered during the first month, and 1% cyclopentolate once a day for the first 4 weeks. Subjects were followed once a week for the next 4 weeks, every 2 months for 6 months, and 12 months after surgery. Direct and indirect ophthalmoscopic ocular examination was performed in all children to determine VAO. In younger or uncooperative children and in the suspected presence of any postoperative complication, an examination using an operating microscope was performed under general anesthesia. Postoperative complications and implanted IOL design were noted.

Based on the three different IOLs implanted, we divided children into three groups. In group A, an Acrysof[R] MA60BM hydrophobic three-piece IOL; in group B, Sensar[R] 40e hydrophobic three-piece IOL; and in group C, an Eyecryl[R] 600 hydrophilic single-piece IOL was implanted in the bag (Table 1).

Statistical Analysis

All data obtained from the study were analyzed using Statistical Package for the Social Sciences version 16 software (SPSS Inc.; Chicago, IL, USA). The one-way ANOVA test and Chi-square test were used to compare data among groups. Statistical significance was taken as p value <0.05.

RESULTS

A total of 65 eyes of 49 patients were included in the study. Among them, 26 (53%) were male and 23 (47%) were female. Patients were aged between 24 and 96 months, and the mean age was 43.40[+ or -]21.14 months.

A total of 33 children underwent unilateral and 16 children underwent bilateral surgery. Based on the three different IOLs implanted, children were divided into three groups (Table 2).

Group A had 22 eyes, and VAO developed in 10 (45.5%) of them. Out of 17 eyes in group B, VAO developed in 7 (41.2%) of them. Group C had 26 eyes, and 16 (61.5%) of them developed VAO. The VAO rate was higher in group C than in the other groups (Table 3), but statistically significant difference was not found among the groups (p=0.353).

We observed fibrin reaction in two eyes in group A, two eyes in group B, and four eyes in group C. Two eyes in group C developed IOL decentration. One eye in group A, one eye in group B, and two eyes in group C developed secondary glaucoma during follow-up period (Table 3). One eye in group A, two eyes in group B, and five eyes in group C underwent reoperation due to VAO development.

We did not observe other complications such as hyphema, iris prolapse, IOL drop, retinal detachment, and endophthalmitis.

DISCUSSION

Primary posterior capsulorhexis does not always guarantee a permanently clear visual axis because anterior surface of the vitreous serves chance for the LEC migration into the visual axis (6). In younger children, AV with PCCC reduces the VAO. However, it is not clear at what age AV should be performed. Basti et al. (7) performed primary posterior capsulotomy with AV in children aged less than 8 years. Vasavada and Desai (8) suggested AV with PCCC in children aged less than 5 years. In five out of eight eyes in which PCCC without AV was performed, VAO was observed, and a secondary procedure was required. Koch and Kohnen reported 20 eyes that underwent different methods of managing the posterior capsule and anterior vitreous. They found that none of the eyes that had PCCC with AV developed visually significant VAO (9). Kugelberg and Zetterstrom (10) reported VAO in 85 eyes that underwent cataract surgery with or without AV according to age (patients aged 0-15 years). They suggested that cataract surgery combined with AV should be performed in younger children. Dahan and Salmenson (11) recommended PCCC and AV in children aged less than 8 years. Fenton and O'Keefe (12) reported a VAO rate of 15.6% performing posterior capsulorhexis without AV. In our study group, children age range from 2 to 8 years. We performed PCCC, AV, and in-the-bag IOL implantation for all children. Most pediatric ophthalmologists agree that IOL implantation is the most suitable treatment for Aphakia rehabilitation, and primary IOL implantation has become the popular and acceptable approach in patients above 2 years of age (13).

Intraocular lens designs and materials are designed to prevent VAO (14). Wilson and Trivedi surveyed ophthalmologists about their choice of IOL for pediatric surgery (15). The AcrySof MA (Alcon Laboratories, Inc., Fort Worth, Texas, USA) series is the most preferred worldwide for sulcus fixation. For in-the-bag fixation, most surgeons prefer the MA series, whereas the SA series is more popular in the United States (16). Our results showed that VAO was the major complication in all groups. We found similar rates of VAO in groups A and B. VAO rate of group C was higher than in other groups, but we did not find a statistically significant difference in VAO among groups.

Trivedi et al. (17) showed that there was no statistically significant difference between implantation of single and three-piece IOLs in infants regarding the development of VAO. The lens design is also another critical factor in LEC migration. The square edge design of the IOLs may prevent LEC migration that is important for avoiding VAO (18-20). The three-piece IOLs provide better adhesion between the anterior and posterior capsules. The single-piece lens has bulky haptics than three-piece IOLs that may lead to LEC migration (14). The hydrophobic acrylic IOLs have less after-cataract formation rate than hydrophilic acrylic IOLs. It has been shown by previous studies that hydrophobic acrylic material contacts firmly with posterior capsule and prevents LEC migration and decreases VAO (21). High permeability of hydrophilic acrylic IOLs allows penetration of nutrients to LECs and increases VAO rate (22, 23). We thought that IOL material and design had low additional effect in reducing VAO. This may occur because of the fact that PCCC and AV eliminate the vitreous and hyaloid face as a scaffold for the LECs' migration to the visual axis.

The purpose of congenital cataract surgery is to provide a clear visual axis. However, anterior segment complications after congenital and developmental cataract surgery are more common in adults. This immune response is generally activated by the presence of an IOL, and response is more aggressive in children than in adults. With decreasing age, immune response increases (3). We observed similar rates of fibrin reaction in groups. This may be explained by no significant difference in age among groups. The similar rates of IOL dislocation between groups may also explained by in-the-bag implantation. In-the-bag placement of the IOL is preferred because it mostly eliminates the risk of lens dislocation, iris capture, and uveal inflammation. Apple et al. (24) showed the advantages of capsular bag fixation over ciliary sulcus implantation. Capsular-fixated IOLs provide less pupillary capture and pigment dispersion, elimination of ciliary body erosion. Moreover, capsular fixation provides better centration and stabilization of IOL when compared with sulcus fixation.

Kugelberg et al. (25) showed that IOL implantation protects against secondary glaucoma. The first theory is that IOL may protect the trabecular meshwork from harmful effects of vitreous chemical components. Secondly, IOLs may also provide a mechanical support for trabecular meshwork (26, 27). We observed similar rates of open angle secondary glaucoma in all groups. Longer follow-up period can increase the incidence of secondary glaucoma.

In our study, the overall rate of VAO appears high compared with existing literature. This may be because VAO was described as a fibrosis of anterior or posterior capsular opening and opacification of anterior vitreous surface that closed or threated the optic visual axis in this study. In other studies, fibrosis of anterior surface of vitreous or posterior surface of IOL that closed the visual axis, accepted as VAO or after-cataract formation (4, 5, 28, 29).

CONCLUSION

Our outcomes showed that different IOLs cause comparable VAO rate in children having undergone congenital cataract surgery at an older age. We conclude that performing a posterior curvilinear capsulorhexis and AV is more important than IOL choice in preventing VAO in late-consulted older children. Long-term studies are needed to understand the importance of IOL selection and to determine the best treatment in this age group.

Ethics Committee Approval: Ethics committee approval was received for this study from the ethics committee of Gaziantep University.

Informed Consent: Written informed consent was obtained from patients' parents who participated in this study.

Peer-review: Externally peer-reviewed.

Author Contributions: Concept--A.M., N.B.; Design - A.M., N.B.; Supervision A.M., N.B.; Resources - A.M., N.B.; Materials--A.M.; Data Collection and/or Processing - A.M., N.B.; Analysis and/or Interpretation - A.M., N.B.; Literature Search - A.M., N.B.; Writing Manuscript--A.M.; Critical Review - A.M., N.B.

Conflict of Interest: The authors have no conflicts of interest to declare.

Financial Disclosure: The authors declared that this study has received no financial support.

REFERENCES

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(3.) Tuncer S, Gucukoglu A, Gozum N. Cataract Extraction and Primary Hydrophobic Acrylic Intraocular Lens Implantation in Infants. J AA-POS 2005; 9: 250-6. [CrossRef]

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(6.) Petric I, Lacmanovic Loncar V. Surgical technique and postoperative complications in pediatric cataract surgery: retrospective analysis of 21 cases. Croat Med J 2004; 45: 287-91.

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(10.) Kugelberg M, Zetterstrom C. Pediatric cataract surgery with or without anterior vitrectomy. J Cataract Refract Surg 2002; 28: 1770-3. [CrossRef]

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(13.) Bartholomew LR, Trivedi RH, Wilson ME. Pediatric cataract surgery and intraocular lens implantation practice styles and preferences of the 2001 ASCRS and AAPOS memberships. J Cataract Refract Surg 2003; 29: 1811-20.

(14.) Mian SI, Fahim K, Marcovitch A, Gada H, Musch DC, Sugar A. Nd: YAG capsulotomy rates after use of the AcrySof acrylic three piece and one piece intraoculer lenses. Br J Ophthalmol 2005; 89: 1453-7. [CrossRef]

(15.) Wilson ME, Trivedi RH. Choice of intraocular lens for pediatric cataract surgery: survey of AAPOS members. J Cataract Refract Surg 2007; 33: 1666-8. [CrossRef]

(16.) Lin AA, Buckley EG. Update on pediatric cataract surgery and intraocular lens implantation. Curr Opin Ophthalmol 2010; 21: 55-9. [CrossRef]

(17.) Trivedi RH, Wilson ME Jr, Bartholomew LR, Lal G, Peterseim MM. Opacification of the visual axis after cataract surgery and single acrylic intraocular lens implantation in the first year of life. J AAPOS 2004; 8: 156-64. [CrossRef]

(18.) Nishi O, Nishi K, Akura J, Nagata T. Effect of round-edge acrylic intraocular lenses on preventing posterior capsule opacification. J Cataract Refract Surg 2001; 27: 608-13. [CrossRef]

(19.) Nishi O, Nishi K, Osakabe Y. Effect of intraocular lenses on preventing posterior capsul opacification: design versus material. J Cataract Refract Surg 2004; 30: 2170-6. [CrossRef]

(20.) Findl O, Menapace R, Sacu S, Buehl W, Rainer G. Effect of optic material on posterior capsule opacification in intraocular lenses with sharp-edge optics. Ophthalmology 2005; 112: 67-72. [CrossRef]

(21.) Abela-Formanek C, Amon M, Schauersberger J, Kruger A, Nepp J, Schild G. Results of hydrophilic acrylic, hydrophobic acrylic, and silicone intraocular lenses in uveitic eyes with cataract. Comparison to a control group. J Cataract Refract Surg 2002; 28: 1141-52. [CrossRef]

(22.) Scaramuzza A, Fernando GT, Crayford BB. Posterior capsule opacification and lens epithelial cell layer formation. Hydrview hydrogel versus AcrySof acrylic intraoculer lenses. J Cataract Refract Surg 2001; 27: 1047-54. [CrossRef]

(23.) Kucuksumer Y, Baerakfar S, Sahin S, Yilmaz OF. Posterior capsule opacification 3 years after implantation of an AcrySof and a Memory Lens in fellow eyes. J Cataract Refract Surg 2000; 26: 1176-82. [CrossRef]

(24.) Apple DA, Reidy JJ, Googe JM, Mamalis N, Novak LC, Loftfield K, et al. A comparison of ciliary sulcus and bag fixation of posterior chamber intraocular lenses. J Am Intraocul Implant Soc 1985; 11: 44-63. [CrossRef]

(25.) Kugelberg M, Kugelberg U, Bobrova N, Tronina S, Zetterstrom C. Implantation of single piece foldable acrylic IOLs in small children in the Ukraine. Acta Ophthalmol Scand 2006; 84: 380-3. [CrossRef]

(26.) Kugelberg M, Shafiei K, Zetterstrom C. Single piece acrysof in the new born rabbit eye. J Cataract Refract Surg 2004; 30: 1345-50. [CrossRef]

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How to cite:

Mete A, Bekir N. Visual Axis Opacification after Congenital Cataract Surgery and Primary Intraocular Lens Implantation: Comparison of Three Different Lenses. Eur J Ther 2018; 24(3): 146-9.

Alper Mete [iD], Necdet Bekir [iD]

Department of Ophthalmology, Gaziantep University, School of Medicine, Gaziantep, Turkey

ORCID IDs of the authors: A.M. 0000-0002-1712-5163; N.B. 0000-0002-6755-2550.

Corresponding Author: Alper Mete E-mail: dralpermete@hotmail.com

Received: 12.12.2017 * Accepted: 20.12.2017

DOI: 10.5152/EurJTher.2017.327
Table 1. Intraocular lenses used in this study

                     ALCON                         AMO
                     AcrySof[R] MA60BM             Sensar[R] 40e

Material             Hydrophobic Acrylate/         Hydrophobic acrylic
                     Methacrylate Polymer optic,   copolymer optic,
                     PMMA haptics                  PMMA haptics
                     (three piece)                 (three piece)
Optic length (mm)      6                             6
IOL length (mm)       13.0                          13.0
Optic--haptic angle   10[degrees]                    5[degrees]
Refractive index       1.55
Optic edge design    Square edge                   Square edge
Haptic shape         Modified C                    Modified C
"A" constant         118.9                         118.4

                     BIOTECH
                     Eyecryl[R] 600

Material             Hydrophilic Acrylic
                     26% CQ
                     optic and haptic
                     (single piece)
Optic length (mm)      6
IOL length (mm)       12.5
Optic--haptic angle    5[degrees]
Refractive index       1.46
Optic edge design    Square edge
Haptic shape         Optimized C
"A" constant         118.0

IOL: intraocular lens

Table 2. Demographic and clinical characteristics of groups

Characteristic                           Group A

IOL                                       Alcon
                                    AcrySof[R] MA60BM
Number of eyes/patients          22/17
Age (a, months Mean+SD Range)    40.9[+ or -]19.9 (24-90)
Sex Male/female                   9/8
Laterality Unilateral/Bilateral  12/5

Characteristic                           Group B

IOL                                        AMO
                                      Sensar[R] 40e
Number of eyes/patients          17/13
Age (a, months Mean+SD Range)    44.6[+ or -]21.9 (24-92)
Sex Male/female                   7/6
Laterality Unilateral/Bilateral   9/4

Characteristic                           Group C               p

IOL                                      Biotech               -
                                      Eyecryl[R] 600
Number of eyes/patients          26/19                         -
Age (a, months Mean+SD Range)    44.7[+ or -]22.5 (24-96)
Sex Male/female                  10/9                      0.998 (c)
Laterality Unilateral/Bilateral  12/7                      0.881 (c)

(a): at the time of surgery; (b): One-way ANOVA test; (c): Chi-square
test; IOL: intraocular lens; SD: standard deviation

Table 3. Rate of complications in groups

                                             No(%)
Complications              Group A    Group B   Group C    p (a)

After--cataract formation  10 (45.5)  7 (41.2)  16 (61.5)  0.353
Fibrin reaction             2 (9.1)   2 (11.7)   4 (15.4)  0.801
IOL decentration            1 (4.5)   0 (0)      2 (7.7)   0.501
Secondary glaucoma          1 (4.5)   1 (5.8)    2 (7.7)   0.902

(a): Chi-square test; IOL: intraocular lens
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Title Annotation:Original Research
Author:Mete, Alper; Bekir, Necdet
Publication:European Journal of Therapeutics
Date:Sep 1, 2018
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