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Virological, serological tumor markers and serum pro and anti-angiogenic factors in the spectrum of chronic liver diseases and hepatocellular carcinoma.

The study was carried out to determine the senstivity and specificity of oc-fetoprotein (AFP) and Desy-carboxyprothrombine (DCP) as a diagnostic marker for hepacellullar carcinoma (hcc) and to study the angiogenic and antiangiogenic factors like vascular endothlial growth factor (VEGF), basic fibroblast growth factor (bFGF), angiogenin and endostatin in patients with hcc.

Serum VEGF, bFGF, angiogenin and endostatin levels were estimated in 60 HCC patients with mean age 57.25 [+ or -] 11.16 years (male:female ratio 38:2), 60 cirrhotics with mean age 49.03 [+ or -] 12.31 years (41 M: 19F), 60 chronic hepatitis patients with mean age 37.68 [+ or -] 12.16 years (53 M:7F) and 60 healthy subjects with mean age 40.08[+ or -]11.03 years (42M:18F) by commercially available ELISA kits. Clinical details of patients were recorded and CT/MRI done in all patients with HCC.

Serum VEGF, bFGF and angiogenin levels were significantly elevated in patients with HCC (413.1 [+ or -]268.7 pg/ml, 26.67 [+ or -] 17.16 pg/ml and 308.87 [+ or -] 163.1 pg/ml) respectively compared with cirrhosis (171.6 [+ or -] 109.8 pg/ml, 20.81 [+ or -] 14.13 pg/ml and 147.21 [+ or -]79.6), chronic hepatitis (141.7[+ or -] 63.7pg/ml, 19.57 [+ or -] 13.11 pg.ml and 134.9 [+ or -] 73.8 pg/ml)and healthy subjects (82.45 [+ or -] 33.6 pg/ml, 15.35 [+ or -] 18.8 pg/ml and 113.9[+ or -]79.1) respectively. Similarly the serum levels of endostatin were significantly elevated in patients with HCC (126.67[+ or -]89.78ng/ml); when compared with cirrhosis (74.8 [+ or -] 36.2 ng/ml); chronic hepatitis (89.9[+ or -]30.77 ng/ml) and healthy subjects (69.6 [+ or -] 30.62 ng/ml). The difference in the levels of the above four markers in cirrhosis, chronic hepatitis and healthy subjects were not significant. No significant relationship of serum levels of VEGF, bFGF and angiogenin was observed with the etiology of HCC but a positive correlation was seen between the tumor size and VEGF levels (p=0.001). High serum VEGF levels were also associated with the portal vein invasion in HCC (p=0.005).

It was concluded that high serum levels of VEGF, bFGF, angiogenin and endostatin were observed in patients with HCC. High VEGF levels may indicate portal vein invasion.

Dr. Y.K. Chawla

Department of Hepatology

Postgraduate Institute of Medical

Education & Research

Chandigarh

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Title Annotation:ABSTRACTS: Some Research Projects Completed Recently
Author:Chawla, Y.K.
Publication:ICMR Bulletin
Article Type:Author abstract
Date:Oct 1, 2010
Words:410
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