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Viralytics reports publication of pre-clinical research on combination of CAVATAK and chemotherapy in breast cancer.

M2 PHARMA-January 13, 2011-Viralytics reports publication of pre-clinical research on combination of CAVATAK and chemotherapy in breast cancer(C)2011 M2 COMMUNICATIONS

13 January 2011 - Australian oncolytic virus technology company Viralytics Ltd (ASX: VLA) announced today the publication of pre-clinical research data on the anti-cancer activity of its lead oncolytic virus candidate, CAVATAKTM (Coxsackievirus A21) in combination with chemotherapy on human breast cancers both in vitro and in vivo.

The combination studies were undertaken over a number of years by researchers in the School of BioMedical Sciences and Pharmacy at The University of Newcastle.

The peer reviewed article entitled "Enhanced oncolysis mediated by Coxsackievirus A21 in combination with doxorubicin hydrochloride" has now been published online in advance of print in the international journal Investigational New Drugs. The article describes the enhanced anti-cancer activity of CAVATAKTM administered in combination with doxorubicin hydrochloride (a chemotherapeutic agent) as a new therapeutic regimen for both laboratory cultures of human breast cancer cells and mouse tumours models of human breast cancer. The presented findings highlight the potential of CAVATAKTM to be used in combination with existing chemotherapy, forming new therapeutic regimes in the treatment of human breast cancer.

Doxorubicin hydrochloride is approved by the US Food and Drug Administration (FDA) for use in the treatment of a number of metastatic human cancers including as breast, gastric, small cell lung and ovarian cancers.

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Publication:M2 Pharma
Date:Jan 13, 2011
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