Printer Friendly

ViiV Healthcare reveals positive results from phase three programme assessing two-drug regimen for HIV.

M2 PHARMA-February 16, 2017-ViiV Healthcare reveals positive results from phase three programme assessing two-drug regimen for HIV

(C)2017 M2 COMMUNICATIONS

United Kingdom-based ViiV Healthcare has revealed positive results from its phase three programme evaluating the safety and efficacy of switching virologically suppressed patients from a three- or four-drug antiretroviral regimen to a two-drug regimen of dolutegravir and rilpivirine, it was reported yesterday.

Use of dolutegravir and rilpivirine as a two-drug regimen for HIV-1 maintenance therapy is investigational and not approved anywhere in the world. The dolutegravir and rilpivirine regimen achieved non-inferior viral suppression at 48 weeks compared with a three- or four-drug regimen in both pooled and individual analyses of the SWORD 1 and SWORD 2 studies (current antiretroviral therapy (CAR) 485/511 (95%), dolutegravir + rilpivirine 486/513 (95%) [adjusted difference -0.2% (95% CI: -3.0%, 2.5%], pooled analysis]).

The programme included two studies with more than 1000 patients who earlier achieved viral suppression on a three- or four-drug (integrase strand transfer inhibitor [INSTI]-, non-nucleoside reverse transcriptase inhibitor [NNRTI]-, or protease inhibitor [PI]-based) antiretroviral regimen. These patients were randomised to either stay on their three- or four-drug regimen or switch to a dolutegravir and rilpivirine regimen.

The safety profiles for dolutegravir and rilpivirine in these studies were consistent with the product labelling for each medicine.

((Comments on this story may be sent to info@m2.com))

COPYRIGHT 2017 Normans Media Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2017 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:M2 Pharma
Date:Feb 16, 2017
Words:230
Previous Article:Horizon Discovery signs agreement with global pharmaceutical company.
Next Article:Merck halts phase 2/3 clinical study of Alzheimer's drug.
Topics:

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters