Variant clinical courses in children with immune thrombocytopenic purpura: sixteen year experience of a single medical center / Cocukluk caginda immun trombositopenik purpur ve farkli klinik seyir: tek merkezin 16 yillik deneyimi.
Objective: Immune thrombocytopenic purpura (ITP) is the most common cause of acquired thrombocytopenia in children. The objective of this study was to evaluate the presenting features, variation in the clinical courses, initial response rate to therapy, and long-term outcome in patients with ITP.
Materials and Methods: Three hundred and fifty out of 491 newly diagnosed patients with ITP between the initial diagnosis ages of 6 months to 16 years were included in this retrospective, descriptive study. Patients with acute vs chronic ITP, acute vs recurrent ITP and chronic vs recurrent ITP were compared in terms of age at diagnosis, gender, initial platelet count, response rate to initial therapy, long-term outcome, and total duration of follow-up.
Results: The clinical courses of the patients were determined as acute, chronic and recurrent in 63.8%, 29.1%, and 7.1%, respectively. Platelet count >20x[10.sub.9]/L and initial diagnosis age >10 years were found to increase the probability of chronic outcome by at least two-fold.
Conclusion: It is concluded that ITP in childhood is a common disease with low morbidity and mortality. In addition to the acute and chronic form, a rare recurrent form, which accounts for about 4-7% of all ITP patients, should be considered. (Turk J Hematol 2010; 27: 147-55)
Key words: Immune thrombocytopenic purpura, children, clinical course, chronic, recurrent, outcome
Received: June 2, 2009
Accepted: March 22, 2010
Amac: Immun trombositopenik purpura (ITP) cocukluk caginda en sik gorillen edinsel trombositopeni nedenlerindendir. Bu calismada, cocuklarda basvuru bulgulari, klinik seyirlerindeki farkhhklar, tedaviye ilk yanit ye uzun donem prognozlarmin degerlendirilmesi amaclanch.
Yontem ye Gerecler: Bu retrospektif, tammlaylci arasfirmaya tarn yap 6 ay-16 yal olan ITP'li 491 hastadan 350'si dahil edildi. Akut, kronik ve rekurren olgular tarn yasi, cinsiyet, basvurudaki trom-bosit sayisi, ilk tedavi yamti, prognoz ve izlem sureleri yonunden ikili gruplar halinde karsilasbrildi.
Bulgular: Hastalarm %63.8'i akut, %29.1'i kronik ve %7.1'i rekurren ITP olarak tammlandi. Trombosit sayisi >20x[10.sub.9]/L ve baruru yasmm >10 yas olmamn kronik ITP olasiligini 2 kat arttirdigi goruldu.
Sonuc: Sonuc olarak ITP, socukluk yas grubunda mortalite ve morbiditesi dusuk bir hastahktir. Akut ye kronik seyirli ITP chsmda, turn ITP olgularimn %4-7'sini olunuran rekurren formlarm da olabilecegi akilda tutulmalidir. [Turk J Hematol 2010; 27: 147-55)
Anahtar kelimeler: Immun trombositopenik purpura, cocuk, klinik seyir, kronik, rektirren, prognoz
Gelis tarihi: 2 Haziran 2009
Kabul tarihi: 22 Mart 2010
Immune thrombocytopenic purpura (ITP) is a common acquired bleeding disorder characterized by increased destruction of antibody-sensitized platelets with normal to increased megakaryocytes in the bone marrow, presence of thrombocytopenia with otherwise normal red cells and leukocytes, absence of splenomegaly, and absence of other causes of thrombocytopenia (1), (2). Variability in the natural history and response to therapy suggest that ITP comprises a heterogeneous pathophysiology (3). ITP affects infants, children, and adults; in the majority of the children, it is an acute, self-limiting disorder with complete resolution of the illness occurring within six months. However, 15%-30% of the children with ITP develop the chronic form of the disease defined as persistence of thrombocytopenia beyond six months. Children with chronic ITP (cITP) manifest variable clinical features and management is controversial (1-5). Response rate to treatment is usually low in cITP; however, in some studies, high rates of spontaneous remission have been reported (6-8).
In addition to the acute and chronic forms of the disease, a recurrent course is also encountered in children. Recurrent ITP (rITP) is characterized by intermittent episodes of thrombocytopenia followed by periods of recovery, unrelated to therapeutic intervention (9), (10). Although first described in 1961 (11), literature on this clinical course of the disease is limited.
At present, the natural course of ITP is not fully understood. There are no established criteria regarding the clinical characteristics of the variant clinical courses, in order to predict the time and risk factors for a chronic outcome, response to treatment and/or ultimate outcome. Furthermore, there is controversy regarding the classification of patients with recurrences.
The objective of our study was to evaluate the presenting features, diversity in clinical courses (including patients with recurrences), response to initial therapy, and long-term outcome in patients with ITP treated in our Pediatric Hematology Division and to share our single-institution, long-term, hospital-based experience together with related information in the literature.
Materials and Methods
Data Collection and Diagnosis
This retrospective, descriptive, cohort study was performed on patients with ITP diagnosed and followed from January 1990 to December 2006 in the Pediatric Hematology Division, Tepecik Training and Research Hospital, Izmir, Turkey. Data regarding 491 children with ITP were evaluated. There is ethical committee approval for the study. Patients less than 6 months and over 16 years at initial diagnosis, non-compliant patients and patients with proven secondary ITP were excluded. A total of 350 patients (186 females, 164 males) between the ages of 6 months to 16 years were included in the study.
Diagnosis of ITP was made by detailed physical examination and history, presence of thrombocytopenia (<150x[10.sup.9]/L) with otherwise normal red cells and leukocytes, evaluation of Giemsastained peripheral blood smear and bone marrow aspiration, and serological tests for infectious causes and autoimmune diseases (1).
Data collected from patients' records included presenting hemorrhagic symptoms, age at diagnosis, gender, platelet count (PC) at diagnosis, the onset of each recurrence, number of recurrences, time elapsed between recurrences and from the initial diagnosis, treatment modality, response to treatment, follow-up duration, type of clinical course, preceding viral or bacterial infection, and medication or vaccination history.
Patients having low PC (<150x[10.sup.9]/L) for less than 6 months were defined as acute ITP (aITP) and patients with thrombocytopenia persisting for more than 6 months after initial diagnosis were defined as cITP. Complete remission was defined as PC > 150x[10.sup.9]/L whereas partial remission was PC between 50-150x[10.sup.9]/L. Patients achieving complete remission after initial diagnosis, but showing recurrences after at least 3 months of remission (with normal PCs) sustained without treatment and then relapsed were defined as rITP  (they achieved complete response to therapy after each recurrence and then relapsed). cITP patients were also evaluated in late-remission and non-remission subgroups. Chronic patients achieving normal PC after at least 6 months (usually 1-10 years) and maintaining the normal PC values thereafter were defined as late-remission cITP. Patients who did not achieve normal PC values within the entire follow-up period were defined as non-remission cITP.
Patients with PC <20x[10.sup.9]/L and/or bleeding symptoms at initial diagnosis were treated. Treatment consisted of high-dose methyl prednisolone (HDMP) or intravenous immunoglobulin (IVIG) and combination therapy of HDMP and IVIG, if the third-day PCs were still <20x[10.sup.9]/L. In patients years, the first choice of therapy was IVIG, whereas HDMP was the first choice in patients >2 years. IVIG was given at a dose of 1 g/kg/day for 2 days; HDMP was given at a dose of 30 mg/kg/day for 3 days and 20 mg/kg/ day for 4 days, consecutively and intravenously. For children >6 years, HDMP was given either orally or intravenously at the same dosage [51. Regarding criteria for response to treatment, complete response (CR) was defined as PC >150x[10.sup.4] and partial response (PR) as PC 50-149x[10.sup.9]/L, including clinical recovery. PC <50x[10.sup.9]/L was defined as non-responsive (NR).
Evaluation and Statistical
Analysis For statistical analysis, SPSS for Windows version 13.0 was used. Independent samples t-test, Pearson [x.sup.2] test, Mann-Whitney U test and linear regression analysis were used. p<0.05 was accepted as statistically significant.
Among 350 patients with ITP, 186 were females; 96.7% had presented with minor bleeding symptoms, either skin and/or mucosal hemorrhage. Three patients presented with epistaxis requiring nasal packing, 5 with gross hematuria and 5 with gastrointestinal bleeding in addition to minor bleeding symptoms. 71% of the patients gave a history of viral illness 3-6 weeks prior to admission.
Median age at diagnosis was 60 months (6 months-16 years) and median initial PC was 9x 109/L. Overall, patients were followed for a median 42 months (range: 7 months-16 years). Clinical forms were determined as aITP in 63.8%, cITP in 29.1% and rITP in 7.1%.
Demographic, clinical and laboratory data of the aITP, cITP and rITP patients are shown in Table 1. Patients with aITP presented at a younger age (median 54 months) than both recurrent (median 75 months) and chronic (median 78 months) patients (p <0.05, p <0.05). 22.5% of chronic patients, 20% of recurrent patients and 11.7% of the aITP patients were >10 years of age. Initial PCs in aITP and rITP patients were significantly lower than in cITP (p <0.05, p <0.05). PC >20x[10.sup.9]/L and initial diagnosis age >10 years were found to increase the probability of chronic outcome (odds ratio [OR] =2) by at least two-fold. Concerning the initial response rate to treatment, CR plus PR rates were highest in acute cases (87.4%), whereas 37.2% (n=38) of the chronic patients were found to be nonresponders. Three patients (12%) with rITP did not respond initially to HDMP but achieved CR by combination therapy (IVIG and HDMP) within 45-90 days.
Table 1. Demographic,clinical and laboratory data of the patients with aITP cITP and rITP Acute Chronic Recurrent No. of patients 223 102 25 Gender, F/M 119/104 53/49 14/11 Age at initial 54 78 75 diagnosis (6-164) (6-192) (22-146) (months) * Age distribution at diagnosis, n (%) 6-24 months 48(21.5) 12(11.8) 1(4) 25-60 months 76 (34.1) 30 (29.4) 9 (36) 6 1-120 months 7:3 37 (36.3) 10(40) (32.7) >120 months 26(11.7) 23 (22.5) 5 (20) Platelet count 8 (1-77) 14 (1-83) 6 (1-30) at diagnosis (x[10.sup.9]/L) * Platelet count 21(7-72) 30 (1-43) 131 at 1 month (27-324) (x[10.sup.9]/L) * Response to initial treatment, n (%) Complete 130 27 (26.5) 12 (48) response (58.2) Partial response 65 (29.2) 37 (36.3) 9 (36) No response 28 (12.6) 38 (37.2) 3(12) Follow-up 36 54 72 duration (7-132) (8-174) (18-141) (months) * * Data are presented as median values (range)
Comparison of the general characteristics of the aITP and cITP are shown in Table 2. Statistical differences were found in age at diagnosis, PC at diagnosis and response rate to initial treatment between acute and overall cITP (p <0.05).
Table 2. Comparison of the general characteristics of the patients with aITP and cITP Acute Chronic p Gender F M 119/l04 53/49 0.81 Age at diagnosis (months) * 54 (6-164) 78 (6-192) 0.00 PC at diagnosis (x[10.sup.9]/L) * 8 (1-77) 14 (1-83) 0.00 < 20x [10.sup.9]/L, n(%) 184 (82.5) 65 (63.7) 0.00 > 20x [10.sup.9]/L, n(%) 39 (17.5) 37 (36.3) Response to initial treatment n(%) Complete response 130 (58.2) 27 (26.5) 0.00 Partial response 65 (29.2) 37 (36.3) No response 28 (12.6) 38 (37.2) Follow-up duration (months) * 36 (7-132) 54 (8-174) 0.00 * Data are presented as median values (range)
Age at diagnosis was not different in cITP vs rITP patients, whereas a significant difference was shown in aITP vs rITP patients (p>0.05). PC at diagnosis and response rate to initial treatment were not found statistically different between acute and recurrent patients (p >0.05). However, PC at diagnosis showed significant difference in cITP vs rITP (p<0.05). Initial response rate to treatment showed marginal significance between cITP and rITP (p=0.05).
Regarding the 102 cITP patients, 77.5% were found to be in the non-remission group, whereas 22.5% (n=23) achieved remission in a median 18 months (8-66 months). Median age at diagnosis of the patients in non-remission and late-remission groups was 96 months and 42 months, respectively (p <0.05). 27.8% of the patients with non-remission cITP were >10 years of age, whereas 4.3% of the late remission group was >10 years at initial diagnosis (p=0.00). PC at initial diagnosis was similar but PC distribution within the follow-up period approached statistical significance between the two groups (p=0.000). Current status revealed no complete remission and 27.8% partial remission in patients with non-remission cITP, whereas all of the patients in late-remission cITP achieved complete remission during the follow-up period (Table 3).
Table 3. Comparison of the 102 patients with cITP with different dinical courses Non-remission Late-remission p No. of patients 79 23 Gender, F /M 44/35 9/14 0.16 Age at 96 (12-193) 42 (6-149) 0.00 diagnosis (months) * Age distribution at diagnosis, n (%) 6-24 months 6 (7.6) 6 (26.1) 25-120 months 51(64.6) 16 (69.6) 0.00 >120 months 22 (27.8) 1 (4.3) PC at diagnosis 14 (1-83) 13 (1-76) 0.81 (x[10.sup9]/L) * Months to 18 (8-66) - achieve remission * Post-remission - 42 (8-118) - follow-up (months) * Total follow-up 54(8-180) 72 (18-156) 0.12 (months) * Current status n (%) Complete 0 23 (100) remission Partial 22 (27.8) 0 - remission No remission 57 (72.2) 0 * Data are presented as median values (range)
Detailed data on the patients with rITP are presented in Table 4 and general characteristics and outcome of patients with rITP are given in Table 5. Median age at initial diagnosis of these patients was 75 months (range: 22-146 months) with female predominance. PC at initial diagnosis was a median 6x[10.sup.9]/L. After achieving complete remission in a median 20 days (at initial diagnosis) and sustaining normal PC for a median 20 months, these patients experienced 1-4 recurrences within the follow-up period of 18-141 months. Fifteen patients (60%) had only one recurrence, whereas 7 (28%) patients had 2, 2 (8%) patients had 3, and 1 (4%) patient had 4 recurrences. The first recurrence was seen between 8-109 months (median 20 months) after initial diagnosis. Time elapsed to 2nd, 3rd and 4th recurrence after diagnosis was 29, 67 and 58 months, respectively (range: 12-117 months). Duration of each recurrence was 5-11 days. Time interval between the recurrences was a median 12 months (range: 4-50 months). Time elapsed after last remission was a median 24 months (6.99 months). Currently, these patients are all incomplete remission.
Table 4. Clinical nc1 laboratory characteristics of thrombocytopenic episodes in rITP Initial 1st 2nd 3rd 4th Diagnosis No. of patients 25 25 10 3 1 PC x[10.sup.9]/L 6 (1-30) 9 11 4 37 * (4-45) (8-22) (3-8) Bleeding 25 20 7 1 0 manifestations ** Treatment/no respom IVIG or HDMP 24/3 22/4 8/0 2/0 0 IVIG or HDMP 3/0 4/0 0 0 0 No treatment 1/- 3/- 2/- 1/- 1/- * Data are presented as median (range) ** Bleedjng manifestations were all minor manifestations. IVIG: Intravenous immunoglobulin; HDMP: High-dose methyiprednisolone Table 5% General characteristics and outcome of 25 patients with rITP No/sex Age at PC at Dx Days to Time of Dx (x[10.sup.9]/L) achieve 1st Months initial recurrence CR ** after Dx * 1/F 124 13,000 30 38 2/M 86 2000 30 16 3/F 95 19,000 15 8 4/F 66 6000 20 71 5/M 45 20,000 5 12 6/F 98 7,000 10 9 7/F 41 13,000 30 60 8/M 51 5,000 60 30 9/F 62 5,000 15 109 10/F 22 8,000 20 13 11/F 125 4,000 30 25 12/F 52 30,000 10 61 13/M 120 4,000 10 36 14/M 48 20,000 30 34 15/M 151 5,000 40 26 16/F 45 6,000 90 9 17F 53 7,000 30 33 18/F 56 4,000 45 12 19/M 34 10,000 15 12 20/F 138 4,000 20 14 21/F 93 3,000 7 31 22/M 81 3,000 30 16 23/M 146 19,000 10 15 24/F 93 1,000 30 34 25/M 75 4,000 10 12 No/sex Time of Time 0f Months Total 2nd 3rd elapsed follow-up recurrence recurrence after * after Dx * after Dx * last remsson 1/F 41 79 2/M 23 39 3/F 12 6 18 4/F 6 77 5/M 22 68 90 6/F 20 70 6 76 7/F 36 96 8/M 37 99 136 9/F 117 24 141 10/F 19 67 53 120 11/F 68 93 12/F 80 141 13/M 96 132 14/M 19 53 15/M 48 12 60 16/F 34 19 53 17F 51 84 18/F 24 53 77 19/M 34 48 11 59 20/F 30 44 21/F 24 55 22/M 39 55 23/M 20 35 24/F 6 40 25/M 10 22 * months Dx: Diagnosis; ** CR: Complete response
Out of 102 cITP patients, 30 (29.4%) underwent splenectomy. Median ages at diagnosis and at splenectomy of these patients were 8.5 years and 10.7 years, respectively. Patients were followed 12-170 months after splenectomy, and within this period, 73.3% achieved complete remission.
Of overall patients, 2 non-remission and 1 late-remission patients with cITP revealed antinuclear antibody (ANA) positivity (1/400). Median age at diagnosis of these patients was 6.5 years and median follow-up duration was 5 years, during which neither clinical nor pathological laboratory data were detected.
One male patient with non-remission cITP developed intracranial hemorrhage at the eighth month of diagnosis with a PC of 7x109/L; he did not respond to medical treatment and was splenectomized. None of the patients in the study group died.
Immune thrombocytopenic purpura (ITP) is a common hemorrhagic disease with a heterogeneous background during childhood. It is likely that all pediatricians will encounter children with ITP at some time in their practice. There are still many questions to be answered regarding the natural progress of the clinical forms and the prediction of chronic or recurrent outcome, response to treatment and ultimate outcome (1-10).
Our results concerning the acute and chronic patients were comparable with other series in terms of the incidence of clinical courses, mean/ median age at diagnosis, male/female ratio, initial PCs, and initial response rates to therapy (12-15). At present, it is difficult to foresee at the time of diagnosis the patients who will develop a chronic course; although age older than 10 years, adolescence in females, and an initial PC >20x[10.sup.9]/L have been associated with a chronic course (12-16). In our study, initial PC >20x[10.sup.9]/L and initial diagnosis age >10 years were found to increase the probability of chronic outcome by at least two-fold (OR=2). Glanz et al. (16) reported an approximate five-fold risk for progressing to chronic disease in children whose illness was diagnosed at [greater than or equal to]10 years of age and who had PC. [greater than or equal to]20x[10.sup.9]/L. Kuhne et al. (12) reported a high incidence of cITP (47.3%) in older children and adolescents.
The majority of the children with cITP have mild bleeding episodes not requiring treatment despite persistent thrombocytopenia. In addition, rates of spontaneous recovery of 30-60% have been reported many years after initial diagnosis (6-8). In our cohort, 102 patients with cITP were evaluated in non-remission and late-remission subgroups. Twenty-three patients (22.5%) achieved complete remission in a median 18 months (8 months-66 months). In 16 of the 23 patients, PC normalized at 8-24 months. Currently, all of the patients in the late-remission group achieved complete remission, whereas 27.8% and 72.2% of the patients in the non-remission cITP subgroup revealed partial remission and no remission, respectively. Ruggiero et al.  reported 5 (41.6%) out of 12 cITP patients approaching complete remission within 15-90 months. Donato et al. (8) reported a 32.9% rate of spontaneous remission in 325 nonsplenectomized children with cITP between 6 months to 11 years; 44.9% approached remission 6-12 months from diagnosis. In Jayabose et al.'s (7) series of 62 cITP patients, a 56% spontaneous remission rate was reported. All of these authors recommended delay or omission of surgical treatment and reservation of splenectomy for patients with severe symptoms and non-responders. Imbach et al. (14) and Donato et al. (8) also reported that the cut-off value to define cITP should be changed from 6 months to 12 months. Our observation, too, showed that the cut-off point of cITP should be changed to 12 months since immune thrombocytopenia could persist beyond 6 months and could recover spontaneously in months to years.
Recurrent ITP (rITP) is a rare clinical course of ITP. It was first described by Walker and Walker (11) in 1961, who defined it as recurrence of ITP after a prolonged remission. Later, Imbach (9) defined it as the recurrence of ITP after at least 3 months of remission (with normal PCs) sustained without any treatment, including splenectomy. Vranou et al. (19) defined rITP as isolated episodes of thrombocytopenic purpura following complete remission, non-related to therapeutic intervention, regardless of the time interval elapsed between the episodes, and reported that the time interval between two episodes less than 1-3 months was identified in 31.1% of the recurrences. Therefore, there is no consensus in the literature about the definition of rITP as to the interval between the episodes.
Since 1961, only series with small numbers of patients have been published on rITP (10), (17-20). Jayabose et al. (10) reported 14 (4.1%) children with rITP among 340 pediatric patients. Median time to recurrence of these patients was 33 months (4-120 months). Twelve (86%) patients had favorable outcome, with 71% achieving complete plus partial remission and 14.2% achieving complete remission after splenectomy. Vranou et al. (19) gave the incidence of rITP as 6% in their childhood ITP series. The majority of their rITP patients had only one recurrence (1-4 recurrences). The time interval between the two recurrences was longer than 3 months (up to 96 months) in two-thirds of the episodes. They observed that the initial episode and the first recurrence generally shared the features of alTP.
The incidence of rITP in our series was 7.1% (25 of 350 patients), which is the highest of those reported by Khalifa et al. (18), Jayabose et al. (10) and Vranou et al. (19). Within the follow-up period of 18-141 months, these patients experienced 1 to 4 recurrences. Sixty percent (n=15) had only one, 28% (n=7) had two, 8% (n=2) had three, and 4% (n=1) had four recurrences. Median time elapsed to first recurrence after diagnosis was 20 months (8-109 months). The time interval before any recurrence was longer than four months (up to 50 months). It was also noted that these patients had low PC at initial diagnosis and at 1st, 2nd and 3rd recurrences and had achieved complete remission at 5-11 days during the recurrence. In addition, rITP and aITP were found comparable in terms of PC at initial diagnosis and response rate to initial treatment, whereas rITP was found comparable to cITP regarding age at diagnosis. PCs at initial diagnosis and during the thrombocytopenic episodes in rITP patients were as low as seen in patients with aITP. We found that the bleeding manifestations in our rITP patients were more prominent in the initial presentation and in the first recurrence, in accordance with the study by Vranou et al. (19), and the bleeding manifestations were less than expected for the low PC in the 2nd, 3rd and 4th recurrences.
There are contradictory reports on the classification of the patients with recurrences. rITP is believed by some to be an exacerbation during the course of a compensated cITP, probably triggered by viral infection (21), (22). In some reviews, it is mentioned as a separate form (10), (18), (19). However, Roganovic et al. (20) reported that it could be characterized as "recurrent acute ITP" or what has been called by Dameshek et al. (17) "intermittent acute ITP". Dameshek et al. (17) showed that recurrent acute ITP was distinct from cITP since platelet survival between episodes was found normal. Our experience with rITP showed us that the majority of these patients generally shared the clinical and hematological features of aITP (low initial PC, high response rate to initial treatment, mild and self-limited course and excellent prognosis). None of these patients presented with major bleeding at any recurrence and none of the patients needed splenectomy. Even though most of these patients presented with low PCs at recurrences, responses to treatment were excellent. Preceding viral infection was noted in 16 patients at initial diagnosis. No previous history of vaccination or medication of any kind was detected at any recurrence. Unlike our favorable results in patients with rITP, Vranou et al. (19) and Jayabose et al. (10) reported 2 cases with rITP who developed intracranial hemorrhage, 1 being fatal. Also, 2 of 14 patients of Jayabose et al. (10) achieved complete remission after splenectomy. The discrepancy between the results of the study groups shows that definition, pathogenesis and outcome of rITP requires more data to be reported.
Splenectomy remains an effective therapeutic option for patients with cITP with severe symptoms and/or nonresponders to pharmacological treatment (23). The rate of splenectomy performed for children with cITP ranges between 9% and 39% in the literature (23-27). However, there are no currently available reliable factors predictive of whom and when to splenectomize and/or foresee the response rate to splenectomy. In our population of 102 cITP patients, 29.4% (n=30) underwent splenectomy with a CR rate of 73.3% and a PR rate of 6.7%. Median ages at initial diagnosis and at splenectomy were 8.5 years and 10.7 years, respectively. Fourteen patients underwent splenectomy between 8-16 months, 6 patients between 2-3 years and 8 patients more than 3 years after the initial diagnosis.
None of the children with ITP had serious bleeding manifestations within the total follow-up period except a three-year-old male patient who experienced an intracranial hemorrhage at the seventh month of diagnosis with a PC= 7x [10.sup.9]/L, who had shown no response to pharmacological therapy; he was splenectomized. He is now six years old and is being followed in our hematology division without neurological sequelae and with PC at 30-50x[10.sup.9]/L.
In conclusion, ITP in childhood is a hemorrhagic disease with diverse natural history. Its heterogeneous background and lack of long-term clinical data cause controversies in classifying and managing patients with ITP. Our experience shows that a late-remission course in patients with cITP should be considered and the cut-off value to define cITP should be changed to 12 months. Children with PC >20x[10.sup.9]/L at initial diagnosis and age at diagnosis >10 years have a two-fold risk for progression to chronic disease. rITP, a rare clinical course that seems to be mild and self-limiting and generally shares the clinical and hematological features of aITP, should also be considered. Splenectomy should be delayed and reserved for children with severe symptoms and/or non-responders. Prospective international long-term studies are needed to enlighten the natural history of the clinical courses and the final outcome in children with ITP.
The authors thank Prof. Hale Oren (Dokuz Eylul University, School of Medicine, Izmir, Turkey) for her contribution in revising the manuscript.
Conflict of interest
No author of this paper has a conflict of interest, including specific financial interests, relationships, and/or affiliations relevant to the subject matter or materials included in this manuscript.
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Address for Correspondence: M.D. Berna Atabay, Saglik Bakanligi Tepecik Egitim ye Arastirma Hastanesi, Yenisehir, Izmir, Turkey Phone: +90 505 479 26 62 E-mail: email@example.com
Isin Yaprak, Berna Atabay, Ikbal Durak, Meral Turker, Haldun Oniz, Esra Arun Ozer
Izmir Tepecik Training and Research Hospital, Izmir, Turkey
doi: 10.51 52/tih.20 10.21
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|Title Annotation:||Research Article|
|Author:||Yaprak, Isin; Atabay, Berna; Durak, Ikbal; Turker, Meral; Oniz, Haldun; Ozer, Esra Arun|
|Publication:||Turkish Journal of Hematology|
|Date:||Sep 1, 2010|
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