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Vaccinia hitched to new load.

Vaccinia hitched to new load

Vaccinia, the workhorse virus used to vaccinate against smallpox, is under investigation as a carrier of genetic material from other ogranisms. Vaccinia hybrids that produce proteins from several viruses have already proved effective in animal trials (SN: 6/15/85, p.379); now researchers from the Bethesda, Md.-based National Institutes of Health have used vaccinia to carry respiratory syncytial virus (RSV) genetic material.

RSV is a common cause of lower respiratory tract infection; in children, its effects range from mild to lethal. The researchers cloned an RSV gene that dictates the production of a glycoprotein, put the copies into vaccinia and inoculated rats with the hybrid organism. The rats produced antibodies to the glycoprotein and were able to resist RSV infection, the researchers report in the March PROCEEDING OF THE NATIONAL ACADEMY OF SCIENCES (No. 7).
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Title Annotation:used to carry respiratory syncytial virus
Publication:Science News
Date:Apr 12, 1986
Words:142
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