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Using EX/RP to treat OCD.

Intensive exposure and response prevention (EX/RP), with or without clomipramine therapy, should be used more widely in the treatment of obsessive-compulsive disorder (OCD) patients, said Dr. H. Blair Simpson of the New York State Psychiatric Institute, New York.

After a 12-week acute phase, those who responded to three treatment protocols were placed into the discontinuation phase and followed for 12 weeks. The treatment protocols of the 46 responders were EX/RP, n=18; EX/RP plus clomipramine, n=15; clomipramine, n=11; and placebo, n=2. Patients were assessed every 4 weeks by an investigator blinded to treatment protocols (Depress. Anxiety 19[4]:225-33, 2004).

Twelve weeks after discontinuing therapy, the relapse rate for EX/RP and EX/RP plus clomipramine patients was a combined 12%, significantly lower than the 45% relapse rate for patients receiving just clomipramine, the investigators said. Clomipramine patients also had a significantly shorter time to relapse after discontinuing treatment than did the two groups using EX/RP. Dr. Simpson added.
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Title Annotation:Clinical Capsules; obsessive-compulsive disorder; Intensive exposure and response prevention
Author:Foley, Kevin
Publication:Clinical Psychiatry News
Article Type:Brief Article
Geographic Code:1USA
Date:Sep 1, 2004
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