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Use of total intravenous anaesthesia in Colombia: a national survey among active anaesthetists in Colombia/Uso de la anestesia total intravenosa en Colombia: encuesta nacional dirigida a anestesiologos activos en Colombia.

Introduction

According to the records of the United States National Medical Library, the first publications on the use of total intravenous anaesthesia (TIVA) came out in the 1970s. Since then, the number of publications has grown year after year, from 20 to 200 in the last decade, (1) bringing to light the benefits of the use of TIVA as compared to other general anaesthesia techniques.

Compared with balanced anaesthesia that uses inhaled anaesthetics through specialised gas delivery systems, TIVA offers clear advantages, including the absence of contamination, negligible cardiovascular depression, low neurohumoral response, reduced oxygen consumption, lower incidence of postoperative nausea and vomiting, early and predictable recovery leading to earlier discharge in outpatient surgery, and less postoperative agitation in high risk patients. (2,3) Moreover, TIVA does not require a sophisticated device for delivering anaesthetic gases or waste gas extraction systems. (4,5) Compared with regional anaesthesia, the only prerequisite for TIVA is the availability of a safe venous line; it takes less time than regional or neuroaxial techniques, and it entails no risk of failed blocks or unpredictable duration of the anaesthesia. (6)

Despite all these benefits, current anaesthesia practice is still dominated by balanced anaesthesia, which combines the use of inhaled agents with intravenous opioids. The choice of one technique over another depends on the anaesthetist's personal experience, patient variables and the availability of supplies and equipment in the work setting. (7) Some of the limitations reported in the literature regarding the use of TIVA include the lack of devices such as infusion pumps in the work place, costs, the unavailability of adequate and safe intravenous drugs, the difficulty in determining the anaesthetic plane, and the lack of education and training for performing the technique. (8,9)

The main objective of this study was to determine the use of total intravenous anaesthesia in the clinical practice in Colombia during the year 2015-2016.

Materials and methods

Cross-sectional cohort study using an on-line questionnaire sent out to a group of active anaesthetists practicing in Colombia taken from the database of the Colombian society of Anaesthesiology and Resuscitation (S.C.A.R.E) from September 1, 2015 to February 1, 2016. In order to optimise the response rate, the survey was developed on the basis of 6 specific questions on the use of TIVA in anaesthesia, requiring less than 5 min to complete. Follow-up phone calls were used to contact the anaesthetists who did not respond to the initial on-line survey, in order to increase the number of responses.

A representative sample of active anaesthetists in Colombia was calculated from the number registered in the SCARE database, and a random selection was made. Anaesthetists who were not actively practicing their profession at the time of the survey were excluded. All the participants agreed to respond to the survey voluntarily and freely and accepted the informed consent used to introduce the survey. The forms were sent by e-mail over the "encuestafacil.com" platform. The questionnaire was sent twice by e-mail and the authors contacted non-responders by telephone in order to increase the number of fully completed responses. The respondents did not receive any form of financial or material incentive to participate. The project was submitted to and approved by the Research Ethics Committee of SCARE, as recorded in Minutes N CE201508 of July 28, 2015. The final manuscript was drafted following the recommendations contained in CHERRIES and in the good practice guidelines for publishing surveys. (10,11)

Statistical analysis

A representative sample was calculated for estimating proportions using a simple random non-replacement method in finite populations in Excel, and random selection was performed using the negative coordinated method in Excel.

A sample of 434 participants was calculated, with a 95% reliability and approximate error of 0.05, out of a universe of 2573 anaesthetists registered in the S.C.A.R.E. database. Response numbers and their proportions were used for the description of categorical items. Only fully completed questionnaires were analysed.

Results

Of the 434 randomly selected anaesthetists, 141 (32.48%) responded the questionnaire, 110 over the web, and 31 by telephone. The frequency of TIVA use was defined as follows: Always, 100% of patients; Almost Always, 50-99% of patients; Hardly Ever, less than 50%; and Never, 0% of cases. The frequency use of the TIVA technique is described in Fig. 1, and it was found that it is used always and almost always by 41.9% of the respondents. The main indications considered by the participants for the use of TIVA were neurosurgery (38.3%), sedation outside the operating room (37.6%), and risk of malignant hyperthermia (36.9%). All other indications were less frequent and are described in Fig. 2. For the question on the use of devices for the administration of intravenous drugs, it was found that TIVA is given mainly with volumetric pumps (53.9%) and TCI (31.9%) pumps. The use of other devices is shown in Fig. 3.

Of the respondents, 60% consider that TCI pumps are absolutely necessary for TIVA administration, while 73% also consider the availability of anaesthetic depth monitoring like BIS or entropy as a pre-requisite for using this anaesthesia technique. Of the respondents, 120 (85.1%) reported having received training in the use of TIVA and 57 (40.4%) reported having TCI pumps available at their work places. The surveyed anaesthetists found that little availability of anaesthesia depth monitoring (48.2%), the lack of infusion pumps (36.9%) and the lack of experience with the technique (29.1%) were the main limitations for the use of TIVA; other limitations are described in Fig. 4.

The scant availability of technology to support TIVA administration and/or monitoring of the depth of anaesthesia are important limitations to the use of this anaesthetic technique because devices like TCI pumps, BIS monitors or entropy increase the safety of the technique. Additionally, the respondents reported that balanced techniques are easier to perform and they are more familiar with this technique when compared with total intravenous anaesthesia.

Discussion

Despite the worldwide expansion of intravenous anaesthesia over the past 20 years, supported by the creation of new drugs with an improved pharmacokinetic profile, the pace of TIVA development varies among the different regions of the world, particularly where financial resources are limited. The aim of this study was to examine the use of total intravenous anaesthesia in our country, the main indications and the limitations identified by the respondents for the adoption of this type of anaesthesia technique. It is the first study of its kind conducted in our country.

Of the total representative sample, the response rate was 32%. The survey showed that total intravenous anaesthesia is used always 5% of the time and almost always 37% of the time. It is interesting to note that anaesthetists in Colombia are familiar with total intravenous anaesthesia techniques due to the availability of hypnotic agents that are predictable, easy to titrate and have a clear pharmacokinetic profile. This has popularised this type of anaesthetic technique among almost half of the anaesthetists surveyed. (12,13)

Many advantages of the intravenous anaesthesia technique have been described and, at present, there are clear recommendations and indications for the use of TIVA both in paediatric as well as adult patients. (14) However, this survey found that the main indications for which the respondents consider the administration of TIVA are neurosurgery (66%), sedation outside the operating room (37.6%), risk of malignant hyperthermia (36.9%) and, less frequently, a history of postoperative nausea and vomiting, intra-operative neurophysiological monitoring, thoracic surgery, otolaryngological surgery, and patients with a history of postoperative delirium or agitation, all of which are described in the literature as indications for administering TIVA. (14)

There are various methods for the administration of total intravenous anaesthesia, including sophisticated infusion pumps based on effector site concentration control known as target controlled infusion (TCI), or plasmatic controlled infusion (PCI) pumps; volumetric pumps based on simulators that use pharmacokinetic models to calculate individualised doses for each patient (15); and manual infusion techniques for a simpler form of TIVA administration that do not required additional devices or technologies. These manual techniques use fixed weight-based concentrations and allow to vary the dose over time in accordance with the needs of the patient or the surgery. These manual infusions may be combined with different pharmacokinetic models in order to estimate effector site concentration. Many of these systems are available for use in our country by means of electronic devices like smart phones, and there are reports of excellent clinical performance for remifentanil and propofol infusions using mathematical algorithms designed to calculate effector site concentration. (16) This study revealed that anaesthetists use mainly volumetric pumps forTIVA administration (53.9%), followed less frequently by TCI pumps (31.9%), macrodrip devices (21.3%), and pharmacokinetic software (6.4%). However, 60% of the respondents believe that TCI pumps are a prerequisite for administering total intravenous anaesthesia as is also the case for the ability to monitor depth of anaesthesia with the help of devices like BIS (bi-spectral analysis) or entropy in order to perform the technique safely and have the ability to predict the state of hypnosis in each patient. (13)

Regarding training and education in intravenous anaesthesia, 120 respondents (85.1%) reported having received some form of education on the technique. This is striking considering that the technique is not generally taught during anaesthesia training. A significant proportion of TIVA education is obtained outside the residence programme, especially through courses taught during congresses, self-learning and the support of peers at work. This appears to be related to the importance that anaesthetists attach to the need to develop knowledge and skills in the use of the technique, prompting them to find other non formal sources of education.

Finally, the main limitations identified in the group of respondents which discourage the use of total intravenous anaesthesia in routine practice include the lack of monitoring of the depth of anaesthesia, the lack of infusion pumps, the lack of expertise in the use of TIVA, the absence of training workshops or practice settings, the prevailing perception that TIVA increases the cost of anaesthesia, the little availability of drugs, the fear of intra-operative recall, little knowledge of drug pharmacology as recognised by some anaesthetists, and finally, the perception of difficulty and lack of confidence to perform this type of technique. Besides these reasons, some anaesthetists reported their preference for balanced techniques combining an inhaled anaesthetic with the intravenous infusion of an opioid. This is so because many practitioners are more familiar with this type of anaesthesia and prefer not to innovate.

It is interesting to note that many anaesthetists believe that the use of total intravenous anaesthesia requires costly technology hardly available in our setting. They reported on the absolute need to have TCI pumps and monitoring of the depth of anaesthesia as prerequisites for administering intravenous anaesthesia. However, ithasbeen shown thatmanual infusion techniques are as effective and reliable as techniques that use TCI pumps, and provide similar anaesthesia quality and no events of intra-operative recall. (15) A survey conducted in the United Kingdom revealed that only 38% of the anaesthetists used TCI pumps, despite their being readily available. (17)

A similar study was conducted in Brazil in 2006 to assess the use of TIVA by means of a survey sent to 150 anaesthetists and 102 residents. The aim of the study was to assess "attitudes" of the respondents towards the technique. The positive factors that supported the use of TIVA were the quality of awakening and the prospect of future development of more drugs suitable for this technique. (8,18) Likewise, the respondents reported a desire to learn and perform total intravenous anaesthesia techniques in their routine practice. They also reported that the availability of BIS monitoring for the depth of anaesthesia would increase the use of TIVA.

Notwithstanding the availability of all these devices, it is important to gain adequate knowledge of pharmacology and pharmacokinetics as the scientific basis for performing the technique safely and predictably, (16) and also as the basis for new research in the area and for the future development of new technologies and pharmacokinetic models. (19)

Limitations

The limitations of the study have to do with the implementation of the survey, the low percentage of responses and the way each participant interprets the questions. Consequently, results cannot be generalised to the practice of anaesthesia in Colombia. The use of a phone call by the authors in order to increase the number of responses may represent a bias in data collection because some of the interviewees may have felt intimidated or obliged to mark a particular answer. Survey-type studies in general have limitations because of the low percentage of responses and the interpretation and interest attached by each participant to the questions.

Conclusions

This study leads the authors to conclude that TIVA is a technique available to most anaesthetists in Colombia, although there is still some confusion regarding indications for its administration. Despite the fact that the majority of the respondents reported having received education on the use of TIVA, results point to the fact that there are misconceptions about the theory and the practical applications, added to the limited availability of the technology. This has had a negative impact on the regular use of TIVA in our setting. Some of the devices used for TIVA administration are a source of concern, as is the case of macrodrip system that may be unpredictable and have a negative effect on patient safety.

Ethical disclosures

Protection of human and animal subjects. The authors declare that no experiments were performed on humans or animals for this study.

Confidentiality of data. The authors declare that they have followed the protocols of their work center on the publication of patient data.

Right to privacy and informed consent. The authors have obtained the written informed consent of the patients or subjects mentioned in the article. The corresponding author is in possession of this document.

Funding

Authors' own resources.

Conflict of interest

None to disclose. Doctors Echeverry-Marin, Vanegas-Saavedra and Leguizamon are afiliated to S.C.A.R.E.

Opinons showed in this paper own to the authors and do not reflect the S.C.A.R.E.'s ones.

REFERENCES

(1.) NCBI. TIVA OR total intravenous anesthesia. US National Library of Medicine; 2015 [cited 2015 Mar 02]. Available from: http://www.ncbi.nlm.nih.gov/pubmed/?term=TIVA+OR+total+ intravenous+anesthesia.

(2.) Visser K, Hassink EA, Bonsel GJ, Moen J, Kalkman CJ. Randomized controlled trial of total intravenous anesthesia with propofol versus inhalation anesthesia with isoflurane-nitrous oxide: postoperative nausea with vomiting and economic analysis. Anesthesiology. 2001; 95:616-26.

(3.) Chandler JR, Myers D, Mehta D, Whyte E, Groberman MK, Montgomery CJ, et al. Emergence delirium in children: a randomized trial to compare total intravenous anesthesia with propofol and remifentanil to inhalational sevoflurane anesthesia. Paediatr Anaesth. 2013; 23:309-15.

(4.) Bajwa SJS, Bajwa SK, Kaur J. Comparison of two drug combinations in total intravenous anesthesia: propofol-ketamine and propofol-fentanyl. Saudi J Anaesth. 2010; 4:72-9.

(5.) Perez Lopez DC, Rodriguez Sanchez G, Tovar Cuevas JR, Vanegas Saavedra A. Comparison of emergence and discharge times between two total intravenous anesthesia techniques: remifentanil and fentanyl. Rev Colomb Anestesiol. 2013; 41:250-6.

(6.) Eikaas H, Raeder J. Total intravenous anaesthesia techniques for ambulator surgery. Curr Opin Anaesthesiol. 2009; 22:725-9.

(7.) Lauder GR. Total intravenous anesthesia will supercede inhalational anesthesia in pediatric anesthetic practice. Paediatr Anaesth. 2015; 25:52-64.

(8.) Wright PJ, Dundee JW. Attitudes to intravenous infusion anaesthesia. Anaesthesia. 1982; 37:1209-13.

(9.) Passot S, Servin F, Allary R, Pascal J, Prades JM, Auboyer C, et al. Target-controlled versus manually-controlled infusion of propofol for direct laryngoscopy and bronchoscopy. Anesth Analg. 2002; 94:1212-6.

(10.) Eysenbach G. Improving the quality of Web surveys: the Checklist for Reporting Results of Internet E-Surveys (CHERRIES). J Med Internet Res. 2004; 6:e34.

(11.) Kelley K, Clark B, Brown V, Sitzia J. Good practice in the conduct and reporting of survey research. Int J Qual Health Care. 2003; 15:261-6.

(12.) Sahinovic MM, Absalom AR, Struys MM. Administration and monitoring of intravenous anesthetics. Curr Opin Anaesthesiol. 2010; 23:734-40.

(13.) Rosero EB. La caracterizacion de la profundidad de la anestesia durante las infusiones controladas a objetivo: no es un trabajo facil. Rev Colomb Anestesiol. 2016; 44:187-9.

(14.) Echeverry PC, Gomez F. Anestesia total intravenosa. In: Jaramillo J, Echeverry PC, Gomez JM, editors. Tratado de Anestesia Pediatrica. Primera edicion Bogota: Editorial Sociedad Colombiana de Anestesiologia y Reanimacion; 2015. p. 768-85.

(15.) Laso LF, Lopez-Picado A, Olea de la Fuente E, Mendiguren A, Sanchez-Castro C, Pipaon L, et al. Induccion con propofol: infusion controlada por objetivo o manual. Un estudio observacional. Rev Colomb Anestesiol. 2016; 44:272-7.

(16.) Ramirez DE, Calvache JA. Diseno y evaluacion del desempeiro del algoritmo iTIVA para la administracion manual de anestesicos intravenosos segun objetivo en sitio efecto. Rev Colomb Anestesiol. 2016; 44:105-13.

(17.) Pardo M. Anesthesia: how to organize and train our teachers. Anesthesiology. 2010; 112:773-4.

(18.) Nora FS, Aguzzoli M, Oliveira Filho GR. Current attitude of anesthesiologists and anesthesiology residents regarding total intravenous anesthesia. Rev Bras Anestesiol. 2006; 56:362-9.

(19.) Mosquera-Dussan OL, Cardenas A, Botero-Rosas DA, Yepes A, Oliveros H, Henao R, et al. Randomized cross-over clinical trial comparing two pharmacokinetic models of propofol using entropy indices. Rev Colomb Anestesiol. 2016; 44:194-202.

Piedad Cecilia Echeverry-Marina (a,b), * Jimmy Arevaloc, Paola Pinzon (c,d,e), Alberto Vanegas-Saavedra (f), Miryam Leguizamon (g)

(a) Coordinator of the National Paediatric Anaesthesia Committee, Sociedad Colombiana de Anestesiologia y Reanimacion (S.C.A.R.E.), Bogota, D.C., Colombia

(b) Instituto de Ortopedia Infantil Roosevelt, Bogota, D.C., Colombia

(c) Fundacion Universitaria de Ciencias de la Salud, FUCS, Bogota, D.C., Colombia

(d) Hospital San Jose, Bogota, D.C., Colombia

(e) Los Nogales, Bogota, D.C., Colombia

(f) Coordinator of the National Total Intravenous Anaesthesia Committee, Sociedad Colombiana de Anestesiologia y Reanimacion (S.C.A.R.E.), Bogota, D.C., Colombia

(g) Research Coordinator, Head of Research and Innovation, Sociedad Colombiana de Anestesiologia y Reanimacion (S.C.A.R.E.), Bogota, D.C., Colombia

** Please cite this article as: Echeverry-Marin PC, Arevalo J, Pinzon P, Vanegas-Saavedra A, Leguizamon M. Uso de la Anestesia Total Intravenosa en Colombia: encuesta nacional dirigida a anestesiologos activos en Colombia. Rev Colomb Anestesiol. 2017; 45:122-127.

* Corresponding author at: Sociedad Colombiana de Anestesiologia y Reanimacion (S.C.A.R.E.), Cra. 15a No. 120 - 74, Bogota, Colombia.

E-mail address: echeverrypiedad@gmail.com (P.C. Echeverry-Marin).

ARTICLE INFO

Article history:

Received 20 December 2016

Accepted 15 February 2017

Available online 31 March 2017
Fig. 1--Frequency of use of total intravenous anaesthesia
(TIVA) among the anaesthetists surveyed.

Frequency of TIVA use

Always          5%
Almost always   36.90%
Hardly ever     40.40%
Never           17.70%

Source: Authors.

Note: Table made from bar graph.

Fig. 2--Main indications for the administration of total
intravenous anaesthesia (TIVA) among the anaesthetists
surveyed.

Tiva indications

Hystory of agitation      8.50%
ENT                       20%
Thoracic surgery          22%
Neuromonitoring           31.20%
PONV                      34%
Malignant                 37%
Sedation outside the OR   37.60%
Neurosurgery              38.30%

Source: Authors.

Note: Table made from bar graph.

Fig. 3--Devices used for administering total intravenous
anaesthesia (TIVA) among the anaesthetists surveyed.

Devices used for administering (TIVA)

Macrodrips           21%
Volumetric pumps     53.90%
TCI pumps            31.90%
Computer simulator   6.40%

Source: Authors.

Note: Table made from bar graph.

Fig. 4--Limitations for the use of total intravenous
anaesthesia (TIVA) among the anaesthetists surveyed.

Limitations for the use of TIVA

No depth monitoring                 48.20%
No infusion pumps                   37%
Lack of experience                  29.10%
Lack of training                    26.20%
Higher cost                         18.40%
No drugs                            16.30%
Fear of intra-operative recall      15.30%
Lack of knowledge of pharmacology   12.80%
Other causes                        18.40%

Source: Authors.

Note: Table made from bar graph.
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Article Details
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Title Annotation:Scientific and Technological Research
Author:Echeverry-Marina, Piedad Cecilia; Arevaloc, Jimmy; Pinzon, Paola; Vanegas-Saavedra, Alberto; Leguiza
Publication:Revista Colombiana de Anestesiologia
Date:Apr 1, 2017
Words:3304
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