Use of plasma therapy for severe fever with thrombocytopenia syndrome encephalopathy.
During 2015, a 62-year-old woman who had a history of treated tuberculous meningitis 10 years earlier was admitted to a tertiary hospital in Seoul, South Korea (Republic of Korea), with a 5-day fever, myalgia, and headache. On hospital day (HD) 2, CSF examination revealed 1 leukocyte/ mm3, protein 35 mg/dL (reference 9-58 mg/dL), glucose 74 mg/dL (reference 45-80 mg/dL), and CSF/blood glucose ratio 0.66 (reference 0.50-0.80). No bacteria or fungi were isolated from CSF. On HD 4, her headache worsened, and she displayed confused verbal responses and lacked orientation of time and place. No focal neurologic signs were observed. On HD 5, magnetic resonance imaging of the brain indicated no additional abnormalities of the parenchyma and extra-axial structures except for a focal parenchymal defect in the right midbrain that had been discovered as a sequelae of tuberculous meningitis 10 years earlier. On HD 7, follow-up CSF examination revealed no leukocytes, protein 57 mg/dL, glucose 209 mg/dL, and CSF/blood glucose ratio 0.62. SFTSV was detected by real-time reverse transcription PCR (online Technical Appendix, http://wwwnc. cdc.gov/EID/article/22/7/15-1791-Techapp1.pdf) in plasma and CSF (Figure). On HD 8, the patient became comatose and had no eye, verbal, and motor responses to noxious stimuli (Glasgow coma scale 3). Bilateral exotropia was noted with spared light and corneal reflexes and oculocephalic responses. Experimental plasma exchange was performed, and her viral load declined slightly; however, consciousness and platelet count did not change. An ABO-identical nurse who had recovered from SFTS in September 2014 agreed to donate plasma; her indirect immunofluorescence antibody assay (IFA) for SFTSV IgG had been 1:1,024 in October 2014. On HD 17, the patient's titer of SFTSV IgG was 1:64 before the plasma therapy. We obtained [approximately equal to] 400 mL of convalescent plasma (IFA assay for SFTSV IgG 1:256 at the time of donation) from the donor and transfused it into the patient on HD 17. The viral load in the blood decreased steeply by a factor of 10 (6 x [10.sup.2] to 6 x [10.sup.1] copies/mL) during the first 7 hours (4-11 pm on HD 17); it then gradually decreased from 3 x [10.sup.1] at 7 am on HD 18 to 6 x [10.sup.0] copies/ mL on HD 20, by which time the patient's mental status had fully recovered (Figure).
This case is unique in that SFTS was detected in CSF in the absence of pleocytosis and with normal CSF protein and glucose levels, as in previous reports on influenza-associated acute encephalopathy (3). Although headache and encephalitis can occur in patients with SFTS (1,2), the pathophysiology of CNS manifestations in SFTS is unknown. As with influenza-associated acute encephalopathy, a possible hypothesis is direct invasion of SFTSV into the CNS; another hypothesis is that elevated cytokine levels or renal and hepatic dysfunction are associated with SFTS encephalopathy.
We are aware of 1 report of a favorable outcome of plasma exchange and ribavirin in 2 patients with SFTS and multiorgan failure in South Korea (4). However, the patients' clinical condition did not substantially improve despite the 5-day plasma exchange therapy and viral load only slightly decreased. Use of convalescent plasma therapy in severe acute respiratory syndrome, influenza A(H1N1) and A(H5N1), and Ebola virus disease has been reported (5-7), but little evidence exists to support its use. However, given the lack of conclusive data, these potential experimental treatments for emerging infectious diseases warrant further study in a clinical trial. Response was favorable in a mouse model of SFTS treated postexposure with antiserum from a patient who had recovered from SFTS (8).
We do not know whether the convalescent plasma therapy given to the patient described here actually had a positive effect because her IFA titer was already increasing around the time she received the plasma therapy. At the time of this writing, 2 patients with SFTS who were treated with intravenous immunoglobulin and corticosteroid had been reported (9). Cautious interpretation of these experimental therapies is necessary because these therapies may not have had anything to do with the patients' recovery.
Author affiliations: Asan Medical Center, University of Ulsan College of Medicine, Seoul, South Korea (S.Y. Park, Y.P. Chong, S.-W. Kwon, S.-H. Kim); Korea Centers for Disease Control and Prevention, Cheongju, South Korea (W. Choi, S.-W. Park, E.B. Wang, W.-J. Lee, Y. Jee)
We thank Kye-Hyung Kim and Jongyoun Yi for performing initial work to demonstrate the evidence of CNS invasion with keen comments on the study.
This study was supported by grants from the Korea Health Technology Research & Development Project through the Korea Health Industry Development Institute, funded by the Ministry of Health and Welfare, Republic of Korea (grant no. HI15C2774) and the Korea Centers for Disease Control and Prevention (grant no. 4800-4837-301).
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(2.) Cui N, Liu R, Lu QB, Wang LY, Qin SL, Yang ZD, et al. Severe fever with thrombocytopenia syndrome bunyavirus-related human encephalitis. J Infect. 2015;70:52-9. http://dx.doi.org/10.1016/jjinf.2014.08.001
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(5.) Mair-Jenkins J, Saavedra-Campos M, Baillie JK, Cleary P, Khaw FM, Lim WS, et al. The effectiveness of convalescent plasma and hyperimmune immunoglobulin for the treatment of severe acute respiratory infections of viral etiology: a systematic review and exploratory meta-analysis. J Infect Dis. 2015; 211:80-90. http://dx.doi.org/10.1093/infdis/jiu396
(6.) Zhou B, Zhong N, Guan Y. Treatment with convalescent plasma for influenza A (H5N1) infection. N Engl J Med. 2007;357:1450-1. http://dx.doi.org/10.1056/NEJMc070359
(7.) van Griensven J, Edwards T, de Lamballerie X, Semple MG, Gallian P, Baize S, et al. Evaluation of convalescent plasma for Ebola virus disease in Guinea. N Engl J Med. 2016;374:33-42. http://dx.doi.org/10.1056/NEJMoa1511812
(8.) Shimada S, Posadas-Herrera G, Aoki K, Morita K, Hayasaka D. Therapeutic effect of post-exposure treatment with antiserum on severe fever with thrombocytopenia syndrome (SFTS) in a mouse model of SFTS virus infection. Virology. 2015;482:19-27. http://dx.doi.org/10.1016/j.virol.2015.03.010
(9.) Kim UJ, Kim DM, Ahn JH, Kang SJ, Jang HC, Park KH, et al. Successful treatment of rapidly progressing severe fever with thrombocytopenia syndrome with neurological complications using intravenous immunoglobulin and corticosteroid. Antivir Ther. 2016 Feb 17. Epub ahead of print. http://dx.doi.org/10.3851/IMP3036
Address for correspondence: Sung-Han Kim, Department of Infectious Diseases, Asan Medical Center, University of Ulsan College of Medicine, 86 Asanbyeongwon-Gil, Songpa-Gu, Seoul, 138-736, Republic of Korea; email: email@example.com
Se Yoon Park,  WooYoung Choi,  Yong Pil Chong, Sun-Whan Park, Eun Byeol Wang, Won-Ja Lee, Youngmee Jee, Seog-Woon Kwon, Sung-Han Kim
 These authors contributed equally to this article.
Please note: Some tables or figures were omitted from this article.
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|Author:||Park, Se Yoon; Choi, WooYoung; Chong, Yong Pil; Park, Sun-Whan; Wang, Eun Byeol; Lee, Won-Ja; Jee, Y|
|Publication:||Emerging Infectious Diseases|
|Article Type:||Letter to the editor|
|Date:||Jul 1, 2016|
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