Printer Friendly

Undifferentiated Pleomorphic Sarcoma of Pancreas: A Case Report and Review of the Literature for the Last Updates.

1. Introduction

Undifferentiated pleomorphic sarcoma (UPS) or previously known malignant fibrous histiocytoma is the most common type of soft tissue sarcoma of middle and late adulthood [1-3]. It is more prevalent in men than in women and usually occurs in the extremities and retroperitoneum. However, digestive organ involvement is extremely rare [4]. UPS of the pancreas is one of the rarest primary nonepithelial tumors in the pancreas which is highly aggressive with poor prognosis [5, 6]. The diagnosis is usually difficult and commonly achieved after surgery. Herein, we report a 72-year-old woman with abdominal pain for about 1 year who underwent total pancreatectomy, and the postoperative pathological examinations revealed UPS.

2. Case Report

A 72-year-old woman was referred to our hospital with pancreatic head and neck carcinoma for more evaluations and surgical operation. She had been suffering from abdominal pain for about 1 year, and the pain has become more intense in the last 6 months. The pain was postprandial and localized to the right upper abdomen. She has become icteric with generalized spread plus itching since past 2 months. The patient had no history of alcohol consumption or smoking. The patient was referred to us with a highly probable diagnosis of pancreatic head and neck carcinoma to be consulted for surgery. Also, a plastic stent was implanted for her in the previous health center due to intraand extrahepatic duct dilation for the relief of patient symptoms and signs. After admission to our hospital, she was evaluated by abdominal computed tomography (CT), endosonographic imaging, and diagnostic ampullary biopsy. The abdominal CT scan with contrast exhibited an 18 mm x 20 mm hypodense mass at the head and neck of the pancreas (Figure 1). Also, endosonographic imaging was performed to rule out periampullary lesions (Figure 2). A 20 mm x 19 mm lesion was seen in the pancreatic head and neck region, and the main pancreatic duct was slightly dilated in the body of the pancreas. Moreover, the common bile duct (CBD) was distally thickened and contained sludge. Subsequently, diagnostic biopsy for pathological assessment was done. The biopsy revealed an irregular gray-creamy soft tissue which had undifferentiated malignant tumor features at microscopic evaluations. During the Whipple procedure, after cutting the neck of the pancreas in the left side of the portal vein, the frozen section revealed more involvement of pancreatic tissue. Although additional 2 cm was resected, the pancreas residue still had tumor involvement, macroscopically. Therefore, the patient was undergone total pancreatectomy.

Postoperative pathological studies were established and indicated a tumor with the greatest dimension of 4 cm which was extended to the duodenum. Invasion of the venous, lymphatic vessels and perineural sites was seen; however, no exact evidence of distant metastasis was found. The periampullary occlusion had hindered the bile flow over time, leading to chronic cholecystitis and pancreatitis which was confirmed by histopathological assessments. The hematoxylin and eosin staining revealed the presence of two cellular populations including spindle fibroblast-like and pleomorphic cells within the tumor. In addition, the proliferation pattern of the mesenchymal cells was storiform (Figure 3(a)). There was not any well-differentiated component in the tumor tissue or adjacent tissue. Overall, the pathologic stage II A was assigned to the tumor. The immunohistochemical staining was performed, and the tumor was positive for CD68, lysozyme, alpha 1-antichymotrypsin, and vimentin (Figure 3). Also, it was negative for S-100P, cytokeratin, epithelial membrane antigen, desmin, CD34, smooth muscle antigen, MDM2, and CDK4. Therefore, the tumor diagnosis was compatible with UPS. The tumor Ki-67 expression was more than 30%. To evaluate metastasis occurrence, contrast-enhanced thoracic high-resolution CT scan and multidetector CTscan of abdominopelvic were done at 6,12, 18, 24, and 36 months after operation, and no evidence of metastasis was detected. Insulin and Creon were started after surgery for long life. The further follow-up investigations were done by periodic CT scan and ultrasonic imaging. Fortunately, she was disease-free during 5-year follow-up and tolerated total pancreatectomy, well.

3. Discussion

There are currently two hypotheses regarding the etiology of UPS. The first one suggests these tumors do not actually represent a type of cancer but rather a common "morphologic pattern" shared by many neoplasms. This common morphologic pattern is probable to be the fate of a final common malignant progression pathway as tumors become progressively more undifferentiated. Therefore, UPS can originate from not only sarcomas but also carcinomas. The second less common one hypothesizes that undifferentiated sarcomas are originated from malignant transformation of mesenchymal stem cells which do not express differentiation markers from the beginning [7, 8].

Primary UPS of the pancreas as a subtype of pancreatic sarcoma is extremely rare [4, 9]. It usually appears as a large mass and its mean diameter is within 4-35 cm range with high recurrence rate and poor prognosis [6, 10]. Clinical presentations are usually epigastric pain, nausea, and vomiting. Some patients may present with weight loss and abdominal mass. According to the location of tumor at pancreas, jaundice is probable [11, 12]. Primary UPS of the pancreas represents a large, heterogeneous, low-attenuation density or multinodular mass with probable intratumoral calcification and a large amount of necrosis in CT scan imaginings. Contrast modalities reveal a nonhomogeneously enhancing mass within the pancreas by enhancing peripheral pseudocapsular mass [5, 13]. Magnetic resonance imaging (MRI) is even more helpful than CT scan, but features are nonspecific for UPS. Primary UPS has high signal intensity on T2weighted MRI. Also, nonhomogeneous isosignal intensity expression can distinguish it from surrounding tissues [14]. Microscopic findings will narrow our spectrum of diagnosis. UPS usually consists of spindle fibroblast-like and round histiocyte-like cells. However, immunohistochemistry (IHC) and genetic test are really necessary for final diagnosis.

Immunohistochemical exams can exclude other mimic tumors and finalize the UPS diagnosis. The absence of characteristic epithelial markers such as desmin, keratin, S-100P, alpha-fetoprotein, and CEA can exclude the epithelial origin. In addition, UPS exhibits characteristic that have strong reactions to vimentin, alpha 1-antichymotrypsin, CD68, and lysozyme as this case did [15, 16]. Most UPS diagnosed tumors may be rather a poorly differentiated sarcoma, specially dedifferentiated liposarcomas. This is due to technical limitations, such as tumor sampling, and technical investigations such as ultrastructural study, immunohistochemistry, and molecular analysis for identifying any evidence of differentiation [17]. The dedifferentiated liposarcomas are characterized by the ring or giant-marker chromosomes derived from the q13-15 region of chromosome 12 which cause amplification of MDM2, CDK4, SAS, and GLI genes [8, 18-20]. Therefore, many papers have introduced the immunohistochemistry assessment of the MDM2 and CDK4 marker expression as a good key to exclude dedifferentiated liposarcoma from the probable diagnoses [21]. In our case, expression of these markers was negative.

The UPS genetic aspects are hard to assess because of the shifting diagnostic criteria used throughout the recent years. In general, their karyotypes have high complexity, with extensive intratumoral heterogeneity. Considerable percent of cases exhibit triploid or tetraploid chromosomes, and a few cases are near-haploid [22, 23]. Although no specific structural or numerical aberrations have emerged, telomeric associations, ring chromosomes, and/or dicentric chromosomes are common. The comparative genomic hybridizations have demonstrated many genomic imbalances like loss of 2p24-pter and 2q32-qter, and chromosomes 11, 13, and 16, as well as the gain of 7p15-pter, 7q32, and 1p31 [24-26]. In addition, it seems 12q13-15 region of chromosome plays a critical role in the development of UPS. Therefore, SAS, MDM2, CDK4, DDIT3, and HMGIC have all been reported to be amplified in MFH [27-29]. Alterations of TP53, RB1, and CDKN2A have been suggested to participate in rising of UPS. This alteration includes mutation and/or deletion, but no apparent relationship with clinical outcome has yet been announced [23, 30, 31].

The origin of the term "malignant fibrous histiocytoma (MFH)" dates back to the early 1960s. Extraction and culturing of cells from some tumors exhibited a storiform pattern which contained pleomorphic and giant cells with phagocytosis-like movements, these features seemed reminiscent of histiocytes. Upon further growth, these cells became elongated and assumed a fibroblastic appearance. Based on these observations, the hypothesis that pleomorphic soft tissue tumors arose from the fibroblastic transformation of histiocytes was suggested [32]. Therefore, the term "malignant fibrous histiocytoma" was chosen. Due to the vast range of histological appearance at the MFH diagnosed tumors, they were further subdivided into (1) storiform-pleomorphic, (2) myxoid (myxofibrosarcoma), (3) giant cell, (4) inflammatory, and (5) angiomatoid [8]. Revision of the previously categorized MFH tumors by available modern immunohistochemical techniques revealed only 13-27% concordance rate over MFH diagnosis. According to the 2002 WHO classification, the term "undifferentiated pleomorphic sarcoma" was replaced by the old MFH terminology. In addition, myxoid and angiomatoid MFH were no longer subtype of MFH and relocation to other categories. The existence of giant cell and inflammatory MFHs as distinct entities was also questioned. Undifferentiated pleomorphic sarcoma with giant cells was named after conditions in which no evidence of differentiation is found plus presence of giant cells. Also, inflammatory MFH can be made only if all markers of a mesenchymal lineage were negative. In the 2002 WHO classification, this term was renamed to undifferentiated pleomorphic sarcoma with prominent inflammation [7, 23, 33-36]. In the 2013 WHO classification, undifferentiated pleomorphic sarcoma and its subtypes were renamed "undifferentiated sarcoma" and reclassified under the undifferentiated/unclassified sarcomas. These tumors showed lack of distinct clinical or morphological characteristics that would otherwise place them under specific types of sarcomas. The new subtypes include (1) undifferentiated spindle cell sarcoma, (2) undifferentiated round cell sarcoma, (3) undifferentiated epithelioid sarcoma, (4) undifferentiated pleomorphic sarcoma, and (5) undifferentiated sarcoma NOS. Genetic subgroups can be really helpful in this family, and this important work is ongoing [37-40].

To the best of our knowledge, 21 cases of pancreas UPS have been reported in the English-language literature up to now (Table 1). They consisted of 15 men and 6 women. The mean age at diagnosis was 55 years, with a range from 22 to 77 years. Three histologic types were observed among the 21 cases: 14 storiform-pleomorphic (or pleomorphic), 3 giant cells, and 4 myxoid. In 11 cases, tumors were located in the body and/or tail of the pancreas and left pancreatectomy and splenectomy were performed. In 9 cases, the tumor was located in the pancreas head and pancreaticoduodenectomy was chosen as the choice treatment. One patient underwent enucleation of the tumor that was located in the uncinate lobe of the pancreas. All disease tumors are categorized based on the previous classification.

Of these 21 UPS cases, one patient died of perioperative complications. Five patients died of the main disease 5, 7, 11, 12, and 24 months after surgery. 2 patients have not been followed up, and 13 patients were alive without evidence of recurrence, with a median follow-up period of 15 months (mean: 17.5 months and range: 2 to 48 months). Only 8 patients survived for more than one year and just 3 for more than two years. It is apparent that exact conclusions can not be made from such a diverse and limited number of cases that lack appropriate follow-up data. Nonetheless, this evaluation of patients with primary pancreas UPS suggests a poor prognosis for long-term survival. This can be explained by the high malignant potential as well as delayed diagnosis. Furthermore, from 21 introduced UPS cases, only 1 case represented evidence of calcification [43] and 7 cases had a necrotic tumor with internal hemorrhage. Based on these observations, it would appear that calcification or necrosis and hemorrhage are not always helpful in differentiating UPS from other tumors in the pancreas.

None of the 21 patients with pancreas UPS had pulmonary, hepatic, or other distant metastasis at the time of surgery. Only one case was reported with lymph node metastases [13]. Also, one case recurrence was reported 11 months after surgery with hepatic and pulmonary metastasis. The patient underwent a multidisciplinary treatment of chemotherapy, radiotherapy, and a right hepatectomy combined with intraoperative radiofrequency ablation. Under multidisciplinary treatment, the patient fully recovered and remained disease-free for about 25 months after tumor recurrence.

In summary, our knowledge about UPS of the pancreas is really inadequate especially because of its rarity. More cases with definitely follow-ups are needed to perform a representative clinical analysis.

https://doi.org/10.1155/2018/1510759

Conflicts of Interest

The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

References

[1] J. C. Gutierrez, E. A. Perez, D. Franceschi, F. L. Moffat, A. S. Livingstone, and L. G. Koniaris, "Outcomes for soft-tissue sarcoma in 8249 cases from a large state cancer registry," Journal of Surgical Research, vol. 141, no. 1,pp. 105-114, 2007.

[2] J. Issakov, Y. Kollender, V. Soyfer et al., "A single-team experience of limb sparing approach in adults with high-grade malignant fibrous histiocytoma," Oncology Reports, vol. 14, no. 4, pp. 1071-1076, 2005.

[3] A. Belal, A. Kandil, A. Allam et al., "Malignant fibrous histiocytoma: a retrospective study of 109 cases," American Journal of Clinical Oncology, vol. 25, no. 1, pp. 16-22, 2002.

[4] M. Peiper, D. Zurakowski, W. T. Knoefel, and J. R. Izbicki, "Malignant fibrous histiocytoma of the extremities and trunk: an institutional review," Surgery, vol. 135, no. 1, pp. 59-66, 2004.

[5] D. M. Liu, R. B. Jeffrey Jr., and R. E. Mindelzun, "Malignant fibrous histiocytoma presenting as cystic pancreatic mass," Abdominal Imaging, vol. 24, no. 3, pp. 299-300, 1999.

[6] J. Jarry, G. Belleannee, C. Laurent, J. M. Coindre, and S. Evrard, "Primary malignant fibrous histiocytoma of the pancreas: benefit of the multidisciplinary approach," European Journal of Gastroenterology and Hepatology, vol. 22, no. 6, pp. 765-768, 2010.

[7] A. P. Dei Tos, "Classification of pleomorphic sarcomas: where are we now?," Histopathology, vol. 48, no. 1, pp. 51-62, 2006.

[8] I. Matushansky, E. Charytonowicz, J. Mills, S. Siddiqi, T. Hricik, and C. Cordon-Cardo, "MFH classification: differentiating undifferentiated pleomorphic sarcoma in the 21st century," Expert Review of Anticancer Therapy, vol. 9, no. 8, pp. 1135-1144, 2009.

[9] A. L. Cubilla and P. J. Fitzgerald, "Tumors of the exocrine pancreas," in Atlas of Tumor Pathology, 2nd Series, Fascicle 19, pp. 98-108, Armed Forces Institute of Pathology, Washington, DC, USA, 1984.

[10] M. F. Brennan, C. R. Antonescu, K. M. Alektiar, and R. G. Maki, "Undifferentiated pleomorphic sarcoma (UPS) (malignant fibrous histiocytoma (MFH) and myxofibrosarcoma)," in Management of Soft Tissue Sarcoma, pp. 143-152, Springer, New York, NY, USA, 2016.

[11] C.-C. Lee, J.-C. Huang, J.-S. Shin, and M.-J. Wu, "Pancreatic sarcoma mimicking pseudocyst after pancreatitis: a case report and review of the literature," Journal of Medical Ultrasound, vol. 23, no. 3, pp. 142-145, 2015.

[12] R. M. Margules, R. E. Allen, and J. E. Dunphy, "Pancreatic tumor of mesenchymal origin presenting as obstructive jaundice," American Journal of Surgery, vol. 131, no. 3, pp. 357-359, 1976.

[13] D. Bastian, A. Ramaswamy, P. J. Barth, B. Gerdes, M. Ernst, and D. Bartsch, "Malignant fibrous histiocytoma of the pancreas," Cancer, vol. 85, no. 11, pp. 2352-2358, 1999.

[14] U. Tateishi, M. Kusumoto, T. Hasegawa, R. Yokoyama, and N. Moriyama, "Primary malignant fibrous histiocytoma of the chest wall: CT and MR appearance," Journal of Computer Assisted Tomography, vol. 26, no. 4, pp. 558-563, 2002.

[15] M. F. Ye, S. Zheng, J. H. Xu, and L. R. Chen, "Primary hepatic malignant fibrous histiocytoma: a case report and review of the literature," Histology and Histopathology, vol. 22, pp. 1337-1442, 2007.

[16] T. Akatsu, M. Tsugita, S. Ro, K. Kameyama, and M. Kitajima, "Primary malignant fibrous histiocytoma of the pancreas: a case with K-ras mutation and a review of the literature," Digestive Diseases and Sciences, vol. 50, no. 12, pp. 2214-2217, 2005.

[17] J.-M. Coindre, O. Mariani, F. Chibon et al., "Most malignant fibrous histiocytomas developed in the retroperitoneum are dedifferentiated liposarcomas: a review of 25 cases initially diagnosed as malignant fibrous histiocytoma," Modern Pathology, vol. 16, no. 3, pp. 256-262, 2003.

[18] E. Wardelmann, H.-U. Schildhaus, S. Merkelbach-Bruse et al., "Soft tissue sarcoma: from molecular diagnosis to selection of treatment. Pathological diagnosis of soft tissue sarcoma amid molecular biology and targeted therapies," Annals of Oncology, vol. 21, no. 7, pp. vii265-vii269, 2010.

[19] S. Pilotti, G. D. Torre, C. Lavarino et al., "Distinct mdm2/p53 expression patterns in liposarcoma subgroups: implications for different pathogenetic mechanisms," Journal of Pathology, vol. 181, no. 1, pp. 14-24, 1997.

[20] A. P. Dei Tos, C. Doglioni, S. Piccinin et al., "Coordinated expression and amplification of the MDM2, CDK4, and HMGI-C genes in atypical lipomatous tumours," Journal of Pathology, vol. 190, no. 5, pp. 531-536, 2000.

[21] M. B. N. Binh, X. Sastre-Garau, L. Guillou et al., "MDM2 and CDK4 immunostainings are useful adjuncts in diagnosing well-differentiated and dedifferentiated liposarcoma subtypes: a comparative analysis of 559 soft tissue neoplasms with genetic data," American Journal of Surgical Pathology, vol. 29, no. 10, pp. 1340-1347, 2005.

[22] F. Aspberg, F. Mertens, H. C. F. Bauer, J. Lindholm, F. Mitelman, and N. Mandahl, "Near-haploidy in two malignant fibrous histiocytomas," Cancer Genetics and Cytogenetics, vol. 79, no. 2, pp. 119-122, 1995.

[23] C. D. Fletcher, K. K. Unni, and F. Mertens, Pathology and Genetics of Tumours of Soft Tissue and Bone, Vol. 4, IARC, Lyon, France, 2002.

[24] A. Mairal, P. Terrier, F. Chibon, X. Sastre, A. Lecesne, and A. Aurias, "Loss of chromosome 13 is the most frequent genomic imbalance in malignant fibrous histiocytomas: a comparative genomic hybridization analysis of a series of 30 cases," Cancer Genetics and Cytogenetics, vol. 111, no. 2, pp. 134-138, 1999.

[25] M. L. Larramendy, M. Tarkkanen, C. Blomqvist et al., "Comparative genomic hybridization of malignant fibrous histiocytoma reveals a novel prognostic marker," American Journal of Pathology, vol. 151, no. 4, pp. 1153-1161, 1997.

[26] F. Parente, J. Grosgeorge, J.-M. Coindre, P. Terrier, O. Vilain, and C. Turc-Carel, "Comparative genomic hybridization reveals novel chromosome deletions in 90 primary soft tissue tumors," Cancer Genetics and Cytogenetics, vol. 115, no. 2, pp. 89-95, 1999.

[27] A. H. Reid, M. M. Tsai, D. J. Venzon, C. F. Wright, E. E. Lack, and T. J. O'Leary, "MDM2 amplification, P53 mutation, and accumulation of the P53 gene product in malignant fibrous histiocytoma," Diagnostic Molecular Pathology, vol. 5, no. 1, pp. 65-73, 1996.

[28] J.-M. Berner, L. A. Meza-Zepeda, P. F. J. Kools et al., "HMGIC, the gene for an architectural transcription factor, is amplified and rearranged in a subset of human sarcomas," Oncogene, vol. 14, no. 24, pp. 2935-2941, 1997.

[29] T. Sakabe, T. Shinomiya, T. Mori et al., "Identification of a novel gene, MASL1 within an amplicon at 8p23. 1 detected in malignant fibrous histiocytomas by comparative genomic hybridization," Cancer Research, vol. 59, no. 3, pp. 511-515, 1999.

[30] A. Simons, M. Schepens, J. Jeuken et al., "Frequent loss of 9p21 (p16INK4A) and other genomic imbalances in human malignant fibrous histiocytoma," Cancer Genetics and Cytogenetics, vol. 118, no. 2, pp. 89-98, 2000.

[31] J. Yoo, H. K. Lee, C. S. Kang, W. S. Park, J. Y. Lee, and S. I. Shim, "p53 gene mutations and p53 protein expression in human soft tissue sarcomas," Archives of Pathology and Laboratory Medicine, vol. 121, no. 4, pp. 395-399, 1997.

[32] L. Ozzello, A. P. Stout, and M. R. Murray, "Cultural characteristics of malignant histiocytomas and fibrous xanthomas," Cancer, vol. 16, no. 3, pp. 331-344, 1963.

[33] C. D. M. Fletcher, "Pleomorphic malignant fibrous histiocytoma: fact or fiction? A critical reappraisal based on 159 tumors diagnosed as pleomorphic sarcoma," American Journal of Surgical Pathology, vol. 16, no. 3, pp. 213-228,1992.

[34] M. D. Murphey, "World Health Organization classification of bone and soft tissue tumors: modifications and implications for radiologists," in Seminars in Musculoskeletal Radiology, Thieme Medical Publishers, Stuttgart, Germany, 2007.

[35] R. L. Randall, K. H. Albritton, B. J. Ferney, and L. Layfield, "Malignant fibrous histiocytoma of soft tissue: an abandoned diagnosis," American Journal of Orthopedics, vol. 33, no. 12, pp. 602-608, 2004.

[36] C. D. M. Fletcher, "The evolving classification of soft tissue tumours: an update based on the new WHO classification," Histopathology, vol. 48, no. 1, pp. 3-12, 2006.

[37] P. Meister, "Malignant fibrous histiocytoma. History, histology, histogenesis," Pathology-Research and Practice, vol. 183, no. 1, pp. 1-7, 1988.

[38] C. D. M. Fletcher, "The evolving classification of soft tissue tumours-an update based on the new 2013 WHO classification," Histopathology, vol. 64, no. 1, pp. 2-11, 2014.

[39] I. Zambo and K. Vesely, "WHO classification of tumours of soft tissue and bone 2013: the main changes compared to the 3rd edition," Ceskoslovenska Patologie, vol. 50, no. 2, pp. 64-70, 2014.

[40] G. A. Saanna, J. Bovee, J. Hornick, and A. Lazar, "A review of the WHO classification of tumours of soft tissue and bone," in ESUN, vol. 10, p. 3, Liddy Shriver Sarcoma Initiative, Ossining, NY, USA, 2013.

[41] T. Ishiguchi, "Malignant fibrous histiocytoma of the pancreas," Rinsho Hoshasen, vol. 31, no. 5, pp. 655-658, 1986.

[42] S. Hasegawa, H. Kurosawa, Y. Obi, K. Yamanaka, K. Nakamur, and T. Abe, "CASE REPORT: Malignant fibrous histiocytoma in the ileum associated with intussusception," Digestive Diseases and Sciences, vol. 49, no. 7-8, pp. 1156-1160, 2004.

[43] J. F. W. Garvey, A. Ng, J. F. England, and D. M. Sheldon, "Malignant fibrous histiocytoma of the pancreas," HPB Surgery, vol. 1, no. 3, pp. 233-237, 1989.

[44] R. R. Pascal, L. Sullivan, L. Hauser, and G. Ferzli, "Primary malignant fibrous histiocytoma of the pancreas," Human Pathology, vol. 20, no. 12, pp. 1215-1217, 1989.

[45] S. Suster, M. Phillips, and M. J. Robinson, "Malignant fibrous histiocytoma (giant cell type) of the pancreas: a distinctive variant of osteoclast-type giant cell tumor of the pancreas," Cancer, vol. 64, no. 11, pp. 2303-2308, 1989.

[46] K. B. Allen, L. J. Skandalakis, B. C. Brown, S. W. Gray, and J. E. Skandalakis, "Malignant fibrous histiocytoma of the pancreas," The American Surgeon, vol. 56, no. 6, pp. 364-368, 1990.

[47] A. Filippini, S. Lucci, A. Berni et al., "Malignant fibrous histiocytoma of the pancreas," Il Giornale di Chirurgia, vol. 13, no. 10, pp. 485-488, 1992.

[48] T. Tsujimura, K. Kawano, M. Taniguchi, K. Yoshikawa, and I. Tsukaguchi, "Malignant fibrous histiocytoma coexistent with mucinous cystadenoma of the pancreas," Cancer, vol. 70, no. 12, pp. 2792-2796, 1992.

[49] S. J. Ben, "Primary malignant histiocytofibroma of the pancreas: apropos of a case," Archives D'Anatomie et de Cytologie Pathologiques, vol. 41, no. 3-4, pp. 167-170, 1993.

[50] E. Balen, "Malignant fibrous histiocytoma of the pancreas," Revista Espanola De Enfermedades Digestivas, vol. 83, no. 6, pp. 475-480, 1993.

[51] R. Haba, S. Kobayashi, E. Hlrakawa et al., "Malignant fibrous histiocytoma of the pancreas," Pathology International, vol. 46, no. 7, pp. 515-519, 1996.

[52] G. Mai, H. U. Baer, M. Mittler et al., "Malignant fibrous histiocytoma of the pancreas," Pancreas, vol. 25, no. 3, pp. 320-324, 2002.

[53] F. Darvishian, J. Sullivan, S. Teichberg, and K. Basham, "Carcinosarcoma of the pancreas: a case report and review of the literature," Archives of Pathology and Laboratory Medicine, vol. 126, no. 9, pp. 1114-1117, 2002.

[54] R.-S. Yu, J.-W. Wang, Y. Chen, W.-H. Ding, X.-F. Xu, and L.-R. Chen, "A case of primary malignant fibrous histiocytoma of the pancreas: CT and MRI findings," World Journal of Gastroenterology, vol. 14, no. 18, pp. 2942-2945, 2008.

[55] P. Gupta, A. Behari, and M. Jain, "A case of primary myxoid malignant fibrous histiocytoma of the pancreas: clinical, histopathology, and immunohistochemistry findings," Journal of Gastrointestinal Cancer, vol. 43, no. 1, pp. S16-S19, 2012.

Behnam Sanei, (1) Amirhosein Kefayat, (2,3) Melika Samadi Parvin Goli, (1) Mohammad Hossein Sanei, (4) Fatemeh Ghahremani and Alireza Amouheidari (6)

(1) Department of Surgery, Isfahan University of Medical Sciences, Isfahan, Iran

(2) Cancer Prevention Research Center, Isfahan University of Medical Sciences, Isfahan, Iran

(3) Department of Oncology, Seyed Al-Shohada Hospital, Isfahan University of Medical Sciences, Isfahan, Iran

(4) Department of Pathology, Isfahan University of Medical Sciences, Isfahan, Iran

(5) Department of Medical Physics, School of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran

(6) Department of Radiation Oncology, Isfahan Milad Hospital, Isfahan, Iran

Correspondence should be addressed to Amirhosein Kefayat; ahkefayat@yahoo.com

Received 1 December 2017; Revised 21 April 2018; Accepted 6 May 2018; Published 31 May 2018

Academic Editor: Simon Ching-Shun Kao

Caption: Figure 1: The preoperative abdominal CTscan exhibited a hypodense lesion in the pancreas head and neck (the black arrow indicates the mass).

Caption: Figure 2: Endosonographic imaging exhibited a hypoechoic lesion at the ampulla.

Caption: Figure 3: (a) Microscopic sections reveal the proliferation of mesenchymal cells in a storiform pattern. Cells consist of two populations including spindle fibroblast-like and pleomorphic cells. (b) The giant cells are positive for CD68 marker. (c) The cells exhibit the diffuse positive reaction to vimentin.
Table 1: Cases of primary UPS of the pancreas in English-language
literature.

Authors (ref. no.)       Year    Age   Sex       Histologic type

Margueles et al. [12]    1976    22     F             Myxoid

Ishiguchi [41]           1986    44     M          Pleomorphic

Hasegawa et al. [42]     1987    44     M           Giant cell

Garvey et al. [43]       1989    77     M     Storiform-pleomorphic

Pascal et al. [44]       1989    39     M     Storiform-pleomorphic

Suster et al. [45]       1989    71     M           Giant cell

Allen et al. [46]        1990    46     M     Storiform-pleomorphic

Filippini et al. [47]    1992    50     F             Myxoid

Tsujimura et al. [48]    1992    43     F     Storiform-pleomorphic

Ben [49]                 1993    72     M     Storiform-pleomorphic

Balen [50]               1993    37     M          Pleomorphic

Haba et al. [51]         1996    70     M     Storiform-pleomorphic

Bastian et al. [13]      1999    67     M     Storiform-pleomorphic

Liu et al. [5]           1999    27     F             Myxoid

Mai et al. [52]          2002    71     F           Giant cell

Darvishian et al. [53]   2002    74     M     Storiform-pleomorphic

Akatsu et al. [16]       2005    67     M     Storiform-pleomorphic

Yu et al. [54]           2008    67     M     Storiform-pleomorphic

Jarry et al. [6]         2010    45     M     Storiform-pleomorphic

Gupta et al. [55]        2012    52     M             Myxoid

Current case             2016    72     F          Pleomorphic

Authors (ref. no.)          Location               Treatment

Margueles et al. [12]         Head          Pancreaticoduodenectomy

Ishiguchi [41]              Body-tail        Left pancreatectomy,
                                                  splenectomy

Hasegawa et al. [42]        Body-tail        Left pancreatectomy,
                                                  splenectomy

Garvey et al. [43]        Uncinate lobe           Enucleation

Pascal et al. [44]            Head          Pancreaticoduodenectomy

Suster et al. [45]            Head          Pancreaticoduodenectomy

Allen et al. [46]          Body-tail,        80% pancreatectomy,
                         local invasion     splenectomy, subtotal
                                                  gastrectomy

Filippini et al. [47]       Body-tail        Left pancreatectomy,
                                                  splenectomy

Tsujimura et al. [48]         Tail             Pancreatectomy,
                                                  splenectomy

Ben [49]                    Body-tail        Left pancreatectomy,
                                                  splenectomy

Balen [50]                  Body-tail           Extended left

Haba et al. [51]              Head          Pancreaticoduodenectomy

Bastian et al. [13]           Body           Left pancreatectomy,
                                            splenectomy, transverse
                                              colectomy, subtotal
                                                  gastrectomy

Liu et al. [5]              Body-tail        Left pancreatectomy,
                                                  splenectomy

Mai et al. [52]               Head          Pancreaticoduodenectomy

Darvishian et al. [53]        Head          Pancreaticoduodenectomy

Akatsu et al. [16]          Body-tail        Left pancreatectomy,
                                            splenectomy, transverse
                                               colectomy, total
                                                  gastrectomy

Yu et al. [54]                Head          Pancreaticoduodenectomy

Jarry et al. [6]              Head             Multidisciplinary
                                                   treatment

Gupta et al. [55]           Body-tail       Distal pancreatectomy,
                                                  splenectomy

Current case              Head and neck     Pancreaticoduodenectomy

Authors (ref. no.)       Follow-up
                          (months)

Margueles et al. [12]     17, NED

Ishiguchi [41]            15, NED

Hasegawa et al. [42]       7, NED

Garvey et al. [43]        48, NED

Pascal et al. [44]         0, DOC

Suster et al. [45]           NF

Allen et al. [46]          5, DOD

Filippini et al. [47]        NF

Tsujimura et al. [48]      5, NED

Ben [49]                  12, DOD

Balen [50]                 7, DOD

Haba et al. [51]          22, NED

Bastian et al. [13]       34, NED

Liu et al. [5]             6, NED

Mai et al. [52]           24, DOD

Darvishian et al. [53]     4, NED

Akatsu et al. [16]        35, NED

Yu et al. [54]            11, DOD

Jarry et al. [6]          11, NED

Gupta et al. [55]          2, NED

Current case              22, NED

M: male; F: female; NF: no follow-up; NED: no evidence of
disease; DOD: dead of disease; DOC: dead of perioperative
complications.
COPYRIGHT 2018 Hindawi Limited
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2018 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Title Annotation:Case Report
Author:Sanei, Behnam; Kefayat, Amirhosein; Goli, Melika Samadi Parvin; Sanei, Mohammad Hossein; Ghahremani,
Publication:Case Reports in Medicine
Article Type:Case study
Geographic Code:7IRAN
Date:Jan 1, 2018
Words:4585
Previous Article:Fat Embolism Syndrome: A Case Report and Review Literature.
Next Article:Penetrating Sacral Injury with a Wooden Foreign Body.
Topics:

Terms of use | Privacy policy | Copyright © 2020 Farlex, Inc. | Feedback | For webmasters