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Understanding carcinogensis; an introduction to the molecular basis of cancer.


Understanding carcinogensis; an introduction to the molecular basis of cancer.

Kiaris, Hippokratis.



177 pages




Kiaris (U. of Athens, Greece) introduces the molecular biology of cancer to an audience that has a basic knowledge of molecular biology, genetics, and oncology. He first introduces basic aspects of tumor biology, including clonal evolution and autonomy; non-autonomy of cancer cells; and cell cycle, senescence, and apoptosis. He then produces a section on genes involved in carcinogenesis that contains chapters on oncogenes, tumor-suppressor genes, genomic instability, cancer epigenetics, the role of the tumor stroma in nonautonomous interactions in carcinogenesis, telomerase and cellular immortality, humor angiogenesis, and metastasis. Next come chapters on tissue context as a determinant of the tumor-suppressive or oncogenic function of certain genes, cancer stem cells, pharmacogenomics and determination of therapeutic efficacy, chemical carcinogenesis, hormones and cancer, and viral oncogenesis. Finally, human and animal models are discussed, along with future perspectives.

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Publication:SciTech Book News
Article Type:Book Review
Date:Dec 1, 2006
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