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UPDATE: Thiazolidinedione Group.

March 2000

This card replaces pages 15 and 16 of the booklet Medicines for People with Diabetes, covering all pills in the thiazolidinedione (THIGH-ah-ZO-li-deen-DYE-own) group. Thiazolidinedione pills make your cells more sensitive to insulin. The insulin can then move glucose from your blood into your cells for energy. Medicines in this group are for people with type 2 diabetes.

Other names for this medicine
Generic name Brand name

pioglitazone Actos
(py-oh-GLIT-uh-zone) (ACT-ose)

rosiglitazone Avandia
(rose-ee-GLIT-uh-zone) (uh-VAN-dee-uh)


How often should I take pioglitazone or rosiglitazone?

* Pioglitazone: Usually once a day.

* Rosiglitazone: Either once or twice a day.

When should I take pioglitazone or rosiglitazone?

* Pioglitazone: At about the same time each day, with or without a meal.

* Rosiglitazone: At about the same time each day, usually in the morning, with or without a meal. Or in the morning and in the evening, with or without meals.

What are the possible side effects of pioglitazone or rosiglitazone?

* If you take pioglitazone or rosiglitazone, it is important for your health care provider to check your liver enzyme levels regularly. Call your doctor right away if you have any signs of liver disease: nausea, vomiting, stomach pain, lack of appetite, tiredness, yellowing of the skin or whites of the eyes, or dark-colored urine.

(Some people who took troglitazone, another thiazolidinedione, have had serious liver problems. Troglitazone is no longer available.)

* Medicines in this group don't cause blood sugar to drop too low. But if you take other diabetes medicines along with medicines in this group, your blood sugar might drop too low. (See pages 27, 28, and 29 for information about low blood sugar.)

* If you take birth control pills, medicines in this group might make your birth control pills less effective in preventing pregnancy. These medicines may increase your chances of getting pregnant.

* You may gain weight while taking these medicines.

* You may be at risk for developing anemia (uh-NEE-mee-ah), which will make you feel tired. Anemia causes your blood to carry less oxygen (OX-ih-jen) than normal.

* You may have swelling in your legs or your ankles, also called edema (eh-DEE-mah).

Are other diabetes medicines used with thiazolidinediones?

Yes, your health care provider may ask you to take another diabetes medicine along with a thiazolidinedione. Or you may take a thiazolidinedione as your only diabetes medicine. These combinations work well together to control blood sugar:

* Pioglitazone with a sulfonylurea (SUL-fah-nil-YOO-ree-ah), metformin (met-FOR-min), or insulin.

* Rosiglitazone with metformin.

National Diabetes Information Clearinghouse

1 Information Way Bethesda, MD 20892-3560 Phone: (301) 654-3327 Fax: (301) 907-8906 Email: ndic@info.niddk.nih.gov

This publication is not copyrighted. The clearinghouse encourages users of this card to duplicate and distribute as many copies as desired. This information is also available under "Health Information" at www.niddk.nih.gov on the Internet.
COPYRIGHT 2000 National Institute of Diabetes & Digestive & Kidney Diseases
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2000, Gale Group. All rights reserved. Gale Group is a Thomson Corporation Company.

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Title Annotation:replaces pages 15 and 16 of Medicines for People with Diabetes booklet
Publication:Pamphlet by: National Institute of Diabetes & Digestive & Kidney Diseases
Article Type:Pamphlet
Date:May 24, 2000
Words:463
Previous Article:Medicines for people with diabetes.
Next Article:Devices for Taking Insulin.
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