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U.K. researchers produce large supply of human stem cells from healthy donors.

HINXTON, U.K., May 10, 2017-One of the largest sets of high quality human induced pluripotent stem cell (iPSC) lines from healthy individuals has been produced by a consortium involving the Wellcome Trust Sanger Institute.

Comprehensively annotated and available for independent research, the hundreds of stem cell lines are a powerful resource for scientists studying human development and disease.

The study also investigates in unprecedented detail the extensive variation among stem cells from different healthy people.

Creating an iPSC is slow and complicated; few laboratories have the facilities to characterize their cells in a way that makes them useful for other scientists to use.

The Human Induced Pluripotent Stem Cell Initiative (HipSci) project used standardized methods to generate iP SCs on a large scale to study the differences between healthy people.

Reference sets of stem cells were generated from skin biopsies donated by 301 healthy volunteers, creating multiple stem cell lines from each person.

The researchers created 711 cell lines and generated detailed information about their genome, the proteins expressed in them, and the cell biology of each cell line.

Lines and data generated by this initiative are available to academic researchers and industry.

The scientists created a comprehensive, high-quality reference set of hiPSC lines from healthy volunteers.

Each was extensively characterized and made available to the wider research community along with the annotation data.

This resource is a stepping stone for researchers to make better cell models of many diseases, because they can study disease risk in many cell types, including those that are normally inaccessible.

By creating more than one stem cell line from each healthy individual, the researchers were able to determine the similarity of stem cell lines from the same person.

The project took four years to complete and required a multidisciplinary approach with many different collaborators, who specialized in different aspects of creating the cell lines and characterizing the data.

Citation: Helena Kilpinen et al., "Common genetic variation drives molecular heterogeneity in human iPSCs," Nature, 2017; DOI: 10.1038/nature22403

Abstract/Article: Contact: Fiona Watt,

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Title Annotation:Basic Research
Author:Watt, Fiona
Publication:Stem Cell Research News
Geographic Code:4EUUK
Date:May 22, 2017
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