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Typhoid vaccines estimated to be 84% effective.


SAN DIEGO-Typhoid vaccines continue to be 84% effective and should be given to patients who are traveling to typhoid endemic areas, based on the results of a survey of case reports to the Centers for Disease Control and Prevention.

Patients also need to be reminded to follow safe food and water precautions, since the vaccine is not 100% effective, Anna Newton, M.P.H., said in an interview during a poster session at IDWeek.

Ms. Newton and her colleagues analyzed 2008-2010 data from the National Typhoid and Paratyphoid Fever Surveillance database, which contains demographic information, travel history and typhoid vaccination status for 5 years before illness onset in cases reported to the CDC.

From 2008 to 2010, there were data for 977 travelers with typhoid fever and 241 with paratyphoid fever. Vaccination status was available in 65% of those with typhoid fever and 50% with paratyphoid fever. From this data the researchers estimated vaccine effectiveness to be 84%, "which is on par with what we expected to find," said Ms. Newton, a surveillance epidemiologist with the CDC's enteric diseases epidemiology branch, Atlanta.

The vaccine is moderate1y effective

Only 6% of patients with typhoid fever and 29% with paratyphoid fever reported having received a typhoid vaccine within the past 5 years.

IDWEEK was the combined annual meetings of the Infectious Diseases Society of America, the Society for Healthcare Epidemiology of America, the HIV Medicine Association, and the Pediatric Infectious Diseases Society. Ms. Newton said she had no relevant conflicts.
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Author:Brunk, Doug
Publication:Internal Medicine News
Date:Nov 15, 2012
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