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Two studies from Denmark yield new research on tuberculosis.

In the first, tuberculosis peptide nucleic acid fluorescence in situ hybridization (TB PNA FISH) was proven effective in distinguishing between tuberculosis and nontuberculous mycobacteria. When TB PNA FISH was evaluated with 30 acid-fast bacillus-positive (AFB(+) cultures from Denmark and 42 AFB(+) cultures from Thailand, 87% of the cultures were correctly identified as Mycobacterium tuberculosis complex (n = 46) or nontuberculous mycobacteria (n = 17). The second study demonstrated that spoligotyping may be useful in the epidemiological testing of M. tuberculosis strains, which have very few copies of the IS6110 element Researchers performed genotyping of all low-copy-number strains cultured since 1992, using the PCR-based method known as spoligotyping. Scientists concluded that the discriminatory power of spoligotyping of low-copy-number M. tuberculosis strains was higher than that of IS6110 fingerprinting.
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Publication:Medical Laboratory Observer
Article Type:Brief Article
Geographic Code:4EUDE
Date:Nov 1, 1999
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