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Two genes for Joseph disease.

Two genes, located on different chromosomes, are associated with Joseph disease, a fatal genetic disorder in which loss of specific brain cell leads to paralysis. The first gene, found on human chromosome 1, appears to cause the disease, which is inherited as a dominant disorder. A second gene, called the modifier gene, reduces the severity of, or even eliminates, Joseph disease in persons who are expected to develop the disease. Abraham I. Grossman of the University of Texas Health Sciences Center at Dallas and his colleagues have located the modifier gene on human chromosome 2.
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Author:Miller, Julie Ann
Publication:Science News
Date:Nov 23, 1985
Words:95
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