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Two doses of flu vaccine protective.

The 2003-2004 influenza vaccine was significantly protective against influenza in an analysis of 29,726 Colorado children aged 6-23 months and aged 6 months to 8 years, reported Debra R Ritzwoller, Ph.D., of Kaiser Permanente Colorado in Denver, and her colleagues (Pediatrics 2005; 116:153-9).

The 2003-2004 flu season in Colorado began in November 2003, at which time 7.3% of children aged 6-23 months were fully vaccinated (two doses) and 19.6% partially vaccinated (one dose) In addition, 7.5% and 7.9% of children aged 2-8 years were fully and partially vaccinated, respectively. The predominant circulating virus that year was slightly different from the one used in the vaccine for that flu season.

However, despite this discrepancy, vaccine effectiveness was 25% and 49%, respectively, against influenzalike illness and against pneumonia and influenza in fully vaccinated children aged 6-23 months. The vaccine effectiveness was 23% and 51%, respectively, against influenzalike illness and against pneumonia and influenza in fully vaccinated children aged 6 months to 8 years. Statistically significant reductions in pneumonia and influenza also occurred in partially vaccinated children aged 6 months to 8 years, but reductions were not significant among partially vaccinated children younger than 6 months.

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Title Annotation:Clinical Capsules
Author:Splete, Heidi
Publication:Pediatric News
Article Type:Brief Article
Geographic Code:1USA
Date:Aug 1, 2005
Words:200
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