Printer Friendly

Twin study sheds new light on links between depression and coronary artery disease.

Byline: ANI

Washington, August 4 (ANI): Studying how major depression and coronary artery disease interact over time and in twin pairs, scientists have painted a more complex picture of the associations between the conditions.

A report on this study, published in the August issue of Archives of General Psychiatry, suggests that the association between coronary artery disease onset and major depression risk is much stronger over time than vice versa.

"While an association between major depression and coronary artery disease has long been noted and recently confirmed, the direction and cause of this association remain unclear," the authors write as background information in the article.

High cortisol levels, inflammation and changes in blood platelet function associated with depression may increase risk for coronary artery disease-a stressful event that may increase risk for depression; and shared genetic or environmental factors may underlie both conditions.

Dr. Kenneth S. Kendler, of Virginia Commonwealth University School of Medicine, Richmond, and colleagues studied 30,374 twins (average age 57) from the Swedish Twin Registry.

The researchers obtained information from telephonic interviews conducted between 1998 and 2003 and also from Swedish hospital discharge and death registers.

The results of statistical models over time and of twin pairs yielded several findings, the authors note.

"First, the lifetime association between major depression and coronary artery disease in this sample was modest and did not differ substantially in men and women. Second, in more informative time-dependent analyses, coronary artery disease onset was associated with a nearly three-fold increased risk for depressive onset in that year and a nearly two-fold increase in subsequent years. The long-term effect of coronary artery disease on risk for major depression did not attenuate over time," they write.

"Third, given an onset of major depression, the risk for coronary artery disease onset was increased 2.5-fold in that year and much more modestly in subsequent years. The ongoing increased risk for coronary artery disease after major depression onset did not attenuate over time. Although modest, this future risk for coronary artery disease was strongly related to the severity and recurrence of major depression.

Indeed, elevated future coronary artery disease risk was confined to individuals with recurrent episodes of major depression or those who meet more than the minimum number of diagnostic criteria," they continue.

In men, according to the researchers, the increased risk for major depression was much greater in the year of coronary artery disease onset than in subsequent years.

The researchers further said that women were found to experience a smaller spike in depression risk after diagnosis with coronary artery disease but had nearly the same risk thereafter.

"When examined separately, in men, environmental effects, which are often acute, have a large role in major depression-coronary artery disease comorbidity, whereas in women, chronic effects, which are in part genetic, are more important. In men, genetic sources of major depression-coronary artery disease comorbidity are more important in younger members of the sample," the authors conclude. (ANI)

Copyright 2009 Asian News International (ANI) - All Rights Reserved.

Provided by an company
COPYRIGHT 2009 Al Bawaba (Middle East) Ltd.
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2009 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Publication:Asian News International
Date:Aug 4, 2009
Previous Article:Pak human rights body condemns killing of Christians in Gojra.
Next Article:Hollywood star Jennifer Aniston "quiets her mind" and "leans herself" through yoga.

Related Articles
Case-control study: depression a risk factor for sudden cardiac death.
Brief depression screen may improve cardiac outcomes.
Depression and heart disease: link is clear.
Childhood trauma raises risk of adult CHD and depression.
Depression after heart disease 'raises heart failure risk'.
Chronic kidney disease patients 'at increased depression risk'.
Genes implicated with Kawasaki disease identified.
Depression, anger 'increase heart disease risk'.
Being depressed could break your heart, literally.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters