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Turner's syndrome yields high hypertensive risk.


LONDON--Hypertensive complications are seen in more than one-third of pregnant women with Turner's syndrome undergoing fertility treatment, according to the results of a longitudinal retrospective study performed in Finland, Denmark, and Sweden.

Of 106 women with Turner's syndrome who conceived after oocyte donation between 1992 and 2011, 35% had hypertensive complications and 20% had preeclampsia. Although there were no maternal deaths, life-threatening complications occurred in four (3.3%) women. This included a case of aortic dissection.

"We think it's very important to have a centralized cardiovascular assessment before pregnancy," Dr. Anna Hagman of Sahlgrenska Hospital, Gothenburg, Sweden, said on behalf of the study team at the annual meeting of the European Society of Human Reproduction and Embryology. This should include echocardiography and magnetic resonance imaging, looking for specific cardiac abnormalities known to affect women with Turner's syndrome.

Turner's syndrome is caused by an aberration of the X chromosome and affects around 1 in 2,500 women. It is associated with increased cardiovascular (CV) morbidity and mortality, which raises concern for women who may want to try to conceive either spontaneously or via assisted conception methods. Women with the condition typically are of short stature and almost all (95%-99%) are infertile. Oocyte donation may offer one of their best chances for becoming pregnant.

The 45, X karyotype was observed in 44% of the women and 9% had a known cardiac defect before pregnancy. Just under half (49%) of women had a CV exam within the 2 years prior to becoming pregnant, and 29% had a CV exam during their pregnancy.

The study was funded by a variety of sources, including the Gothenburg Medical Society; grants from the ALF agreement at the Sahlgrenska Hospital; and others.

No conflict of interest was reported.
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Title Annotation:OBSTETRICS
Author:Freeman, Sara
Publication:OB GYN News
Article Type:Clinical report
Geographic Code:4EUSW
Date:Oct 1, 2013
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