Tuberculosis: Guidelines Changed for Latent TB Treatment.
The new guidelines were published in the August 31, 2001 MMWR (Morbidity and Mortality Weekly Report), volume 50, number 34, pages 733-735. We cannot summarize them because there are many special cases. For most patients, especially those who are HIV-negative, the older nine-month regimen of isoniazid (INH) should be used. The persons with HIV, the guidelines include the following:
"Available data do not suggest excessive risk for severe hepatitis associated with RIF-PZA treatment among HIV-infected persons. In a large multinational trial, HIV-infected patients treated with RIF-PZA had lower rates of serum aminotransferarase (AT) elevations than those given INH alone. The RIF-PZA regimen also was well tolerated when given twice weekly to HIV-infected persons in Zambia and Haiti. However, experience from trials may not translate to all clinical practice settings, and it may be prudent to use 9 months of daily INH for treatment of HIV-infected persons with LBTI [latent TB infection] when completion of treatment can be assured."
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|Publication:||AIDS Treatment News|
|Article Type:||Brief Article|
|Date:||Sep 21, 2001|
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