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Trovagene Initiates First Clinical Site for Evaluation of PCM-075 in AML.

M2 PHARMA-November 14, 2017-Trovagene Initiates First Clinical Site for Evaluation of PCM-075 in AML


- San Diego, California-based molecular diagnostics company Trovagene, Inc. (NASDAQ: TROV) has activated its clinical trial site for its Phase 1b/2 multicenter trial of PCM-075 in patients with acute myeloid leukemia with Virginia Cancer Specialists, the company said.

This Phase 1b trial, a dose escalation study to determine a recommend phase 2 dose, will enroll subjects who have relapsed or have resistant disease to no more than three prior regimens.

The Phase 2 continuation study will provide preliminary evaluation of anti-leukemic activity and will enroll newly diagnosed subjects, judged to be ineligible for, or who have refused, standard intensive induction therapy, as well as subjects who have relapsed after treatment with no more than one prior regimen.

PCM-075, a highly-selective adenosine triphosphate competitive inhibitor of the serine/threonine polo-like-kinase 1 (PLK 1) enzyme, which is over-expressed in multiple hematologic and solid tumor cancers, is oral, and has a 24-hour drug half-life with reversible on-target hematologic toxicities.

Trovagene believes that targeting only PLK1 with reversible on-target activity and an improved dose/scheduling protocol can significantly improve on the long-term outcome observed in previous studies with a PLK inhibitor in AML.

Trovagene is developing oncology therapeutics for improved cancer care by leveraging its proprietary Precision Cancer Monitoring technology in tumor genomics.

The company has broad intellectual property and proprietary technology to measure circulating tumor DNA (ctDNA) in urine and blood to identify and quantify clinically actionable markers for predicting response to cancer therapies.

Virginia Cancer Specialists is dedicated to the fight against cancer and diseases of the blood. The company's integrated treatment approach provides access to expanded services, including medical oncology and hematology, radiation therapy, breast surgery, orthopedic oncology and surgery, genetic counseling, palliative medicine and the only known dedicated oncology research facility in Northern Virginia to include Phase 1 clinical trials.

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Publication:M2 Pharma
Geographic Code:1U5VA
Date:Nov 14, 2017
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