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Treating hypertension with certain diuretics can produce abnormalities.

CANADA -- Thiazide diuretics are commonly used to treat hypertension (high blood pressure). Hydrochlorothiazide (HCTZ) continues to be the most popular thiazide, although some studies have favored chlorthalidone. Researchers conducted a cohort observational study of patients 66 years of age and older to determine which medication might be more effective in patients with uncomplicated hypertension.

During the 5-year follow-up period, there were no significant differences between the two (3.2 adverse events per 100 patients receiving chlorthalidone and 3.4 events per 100 patients receiving HCTZ). Patients who were treated with chlorthalidonerwere more likely to be hospitalized with hypokalemia (insufficient potassium levels) and hyponatremia (insufficient sodium chloride levels).

Patients who initially received daily doses of HCTZ in increments of 12.5 miligrams (mg.), 25 mg., or 50 mg. were compared with patients receiving the same amount of chlorthalidone. Electrolyte abnormalities were more common with chlorthalidone treatment.

(Source: Annals of Internal Medicine, March 19, 2013.)

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Publication:Nutrition Health Review
Date:Jun 22, 2012
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