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Transplant drug binds to blood cells.

Transplant drug binds to blood cells

The recent success of kidney, liver and heart transplants rests on the use of cyclosporine, a drug that suppresses the patient's normal immune response, which would otherwise reject the foreign tissue. But patients vary widely in how much drug must administered to have the optimal effect. A protein present on red blood cells may be the explanation for these differences, say scientists at Georgetown University Medical Center in Washington, D.C.

Most of the cyclosporine in a patient's blood binds to a single protein, and different patients have quite different levels of the protein, Richard A. McPherson and his colleagues report. The next step in the research will be to determine whether being bound to the protein contributes to or inhibits cyclosporine's action. Measurement of the binding protein may be useful to predict the cyclosporine dose a patient requires. Transplant patients take cyclosporine for the rest of their lives.
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Title Annotation:cyclosporine
Author:Miller, Julie Ann
Publication:Science News
Date:Apr 12, 1986
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