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Transluminal Nd: YAG laser embolysis for branch retinal artery occlusion: a case Report/Retinal arter dal tikanikliginda transluminal Nd: YAG lazer embolizis, olgu sunumu.


A 57-year-old, male, type 2 diabetic patient with the diagnosis of acute form of right eye inferotemporal branch retinal artery occlusion which occurred three days ago was reported. The patient complained of right eye visual field deficit (horizontal upper quadrant) with decreased visual acuity of finger counting from two meters. On fundus examination, calcific embolus was noted with inferotemporal branch artery occlusion and macular edema. The embolus was fragmented (embolysis) with the Nd:YAG laser technique. Subhyaloid hemorrhage developed and was drained by postetiot hyaloidotomy with Nd:YAG laser at the same session. Visual acuity increased and hemorrhage gradually absorbed on follow-up period. Final visual acuity was 8/10 with eccentric fixation. Recovery of blood flow in the occluded arteriole both in fundus examination and fluorescein angiography were noted. (Turk J Ophthalmol 2012; 42: 303-5)

Key Words: Calcific embolus, branch retinal artery occlusion, Nd:YAG laser embolysis


Tip 2 diyaberi olan 57 yasinda erkek hasta, sag gozunde uc gun once akut gelisen horizontal ust kadran defekti ve azalmis gorme keskinligi (2 mps) ile basvurdu. Fundus muayenesinde kalsitik emboli varliginda inferoremporal retinal arter dal tikanikligi ve makuler odem goruldu. Emboli, Nd: YAG lazer teknigi ile parcalandi (embolizis). Ayni seansda subhyaloid hemoraji gelisti ve Nd: YAG laser ile posrerior hyaloidotomi yapilarak drene edildi, izlem doneminde gorme keskinliginde artis, hemorajide cekilme goruldu. Son muayenesinde ekzanttik fiksasyon ile gorme keskinligi 8/10 olarak olculdu. Hem fundus muayenesinde hem de floresein anjiografide kan akiminin duzeldigi izlendi. (Turk J Ophthalmol 2012; 42: 303-5)

Anahtar Kelimeler: Kalsifik emboli, retina arrer dal Tikanikligi, Nd: YAG lazer embolizis


Recently, the neodymium:yttrium aluminum gamet (Nd:YAG) laser was used to perform transluminal Nd:YAG laser embolysis (TYE) in patients with central retinal artery occlusion (CRAO), branch retinal artery occlusion (BRAO) and a cilioretinal artery occlusion. (1-3) It has been hypothesized that it might be possible to selectively photodisrupt a solid embolus within a retinal arteriole without significant damage to the vessel wall. TYE resulted in photofragmentation of the emboli and immediate restoration of retinal blood flow.

Herein, we describe the evaluation of a patient who had BRAO and the clinical efficacy of the TYE on BRAO with visible embolus.

Case Report

A 57-year-old man presented with a history of sudden loss of vision in his right eye which occurred three days ago. At the time of ocular examination, his visual acuity was counting fingers from two meters in the right eye and 20/20 in the left eye. Moreover, the patient complained of visual field deficit (horizontal upper quadrant) of the right eye. Intraocular pressure (IOP) and the slit-lamp examination were normal in both eyes. He had no ocular history of disease, surgery, or trauma to either eye. He had well-controlled type 2 diabetes mellitus, diagnosed five years ago. On fundus examination, calcific embolus was noted with inferotemporal BRAO and narrowed arterioles with partial macular edema in the right eye (Figure 1). The fundus of the left eye was normal.

After obtaining an informed consent for TYE for BRAO, the right eye was anesthetized with topical drops. A Goldmann fundus contact lens (Ocular Instruments, Bellevue, WA) was used to focus the Nd:YAG laser (Coherent 7970, Palo Alto, CA) on the embolus within the retinal artery. A 2.0 mj pulse was initially delivered directly to the embolus which yielded no retinal tissue response. The energy was increased in 2mJ increments without tissue response until the setting was placed at 6.0 mj for embolysis. Although the laser energy was applied for embolysis, a small opening was made in the arteriolar wall at the same time and just after the laser application with 6.0-mJ, suddenly subhyaloid hemorrhage developed overlying the occluded vessel area (Figure 2). During the embolysis and opening the arteriol wall, some part of the embolus could have been passed into the vitreous. Just after the subhyaloid hemorrhage, we pressed the eye with contact lens and continued to perform the laser application with the same energy level for draining the hemorrhage by posterior hyaloidotomy. One week after the TYE procedure, the patient's visual acuity did not change but he reported a significant subjective increase in his visual acuity. Fundus examination revealed that subhyaloid hemorrhage had decreased in size.



At the third month, his best-corrected visual acuity had improved to 8/10 with the help of head movement. Fluorescein angiography still demonstrated the presence of the embolus with a restoration of retinal arteriolar blood flow and regression of macular edema. Ophthalmoscopy demonstrated the evidence of a part of an intraluminal embolus with increased caliber of the arterioles (Figure 3). His condition did not change after 18 months.


There is no known effective treatment for BRAO. Numerous treatment modalities have been attempted in both CRAO and BRAO without much success including low-intensity photocoagulation, intravenous prostaglandin El infusion, and enhanced external counter pulsation. (1,3.4)

Recently, Opremcak and Benner5 used the Nd:YAG laser to perform TYE in two patients with BRAO and a cilioretinal artery occlusion. TYE resulted in disappearance of the emboli and immediate restoration of retinal blood flow. They suggested that this technique might be beneficial in eyes with RAO where an embolus is visible. Mason et al. (1) reported five patients with BRAO who were treated with TYE. They noted that all patients showed improvement in bestcorrected visual acuity one day after TYE. Fluorescein angiography showed immediate and dramatic restoration in flow past the obstructed arteriole in all patients. After their pilot report, again Opremcak et al. (3) reported their experience with TYE or embolectomy in 19 patients (9 BRAO and 10 CRAO) over a 5-year period. All of the patients had immediate and dramatic restoration of retinal blood flow following TYE or embolectomy as documented by fluorescein angiography. Furthermore, they mentioned that they did not find a correlation between duration of the RAO and vision recovery. Seven patients had vitreous hemorrhage at the time of the embolectomy.


One patient developed a large subhyaloid hemorrhage in an area corresponding to the vascular supply of the occluded BRA. Our patient also had a large subhyaloid hemorrhage at the time of the embolectomy. By this way, part of the embolus could pass into the vitreous. After performing posterior hyaloidotomy with Nd:YAG laser at the same session, we noted the regression of the embolus and an increase in the caliber of the arterioles during the follow-up period. Moreover, after performing TYE, photodisruption of the embolus could have supported the reflow of retinal blood through the recanalization of the embolus.

The potential risks of TYE include subhyaloid and vitreous hemorrhage, retinal tears, choroidal neovascularization, and epiretinal membrane formation. (1,3,5) The risks of TYE need to be weighed against the permanent and often severe loss of vision due to arteriolar occlusion. As mentioned in previous studies, it is possible that the improved visual acuities in patients with BRAO were unrelated to TYE or embolectomy. (1,3-5) However, the synchrony of recirculation and restoration of vision immediately following TYE or embolectomy suggests a beneficial effect of this procedure. In light of our experience in this case, TYE can be taken into account and can be an option and feasible technique for restoring retinal blood flow and allowing for retinal recuperation and return of visual function in the majority of patients with BRAO.

DOI: 10.4274/tjo.42.25633


(1.) Mason JO, Nixon PA, Albert MA. Trans-luminal Nd:YAG laser embolysis for branch retinal artery occlusion. Retina. 2007;27:573-7.

(2.) Feist R, Emond TL Transluminal Nd:YAG laser embolysis for centralretinal artery occlusion. Retina. 2005;25:797-9.

(3.) Opremcak EM, Rehmar AJ, Ridenour CD, Borkowski LM, Kelley JK. Restoration of retinal blood flow via transluminal Nd:YAG laser embolysis/embolectomy (TYL/E) for central and branch retinal artery occlusion. Retina. 2008;28:226-35.

(4.) Dutton GN, Craig G. Treatment of a retina! embolus by photocoagulation. Br J Ophthalmol. 1989;73:580-1.

(5.) Opremcak EM, Benner JD. Transluminal Nd:YAG laser embolysis for branch retinal artery occlusion. Retina. 2002;22:213-6.

Nilufer Kocak, Suleyman Kaynak, Ilker Bicer *, Tulin Kaynak *, Gul Yucad *

Dokuz Eylul University, School of Medicine, Ophthalmology Department, Izmir, Turkey * Izmir Retina Ophthalmic Research Center, Izmir, Turkey

Address for Correspondence/Yazisina Adresi: Dr. Nilufer Kocak, Dokuz Eylul University, School of Medicine, Ophthalmology Department, Izmir, Turkey Phone: +90 232 412 30 62-3051 E-mail: Received/Gelis Tarihi: 04.05.2011 Accepted/Kabul Tarihi: 26.12.2011
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Title Annotation:Case Report/Olgu Sunumu
Author:Kocak, Nilufer; Kaynak, Suleyman; Bicer, Ilker; Kaynak, Tulin; Yucad, Gul
Publication:Turkish Journal of Ophthalmology
Date:Jul 1, 2012
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