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Traffic particles and telomere length.

Telomere length reflects biological age and is inversely associated with risk of cardiovascular disease (CVD). Ambient air pollution is associated with CVD, but its effect on telomere length is unknown. McCracken et al. (p. 1564) investigated the association of ambient black carbon (BC), a marker for traffic-related particulate matter (PM), with telomere length in never-smoking men from the Normative Aging Study. Leukocyte telomere length (LTL) was measured repeatedly about every 3 years from 1999 through 2006 using quantitative polymerase chain reaction. BC concentration at men's residences during the year before each LTL measurement, which was estimated based on a spatiotemporal model calibrated with BC measurements, was inversely associated with telomere length. The authors conclude that long-term exposures to airborne PM, particularly those rich in BC, contribute to telomere attrition.
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Title Annotation:Research
Publication:Environmental Health Perspectives
Article Type:Brief article
Date:Nov 1, 2010
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