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Toxicologic pathology; nonclinical safety assessment.


Toxicologic pathology; nonclinical safety assessment.

Ed. by Pritam S. Sahota, James A. Popp, Jerry F. Hardisty and Chirukandath Gopinath.

CRC Press


999 pages




Pathologists Sahota, Popp, Hardisty, and Gopinath compile 21 chapters by academics and industry professionals from the US and Europe, who discuss nonclinical safety assessment for students, residents, toxicologists, pathologists, and toxicologic pathologists working in pharmaceutical drug research, to demonstrate pharmacological or off-target effects and improve the quality of drug safety evaluation. They begin with concepts in drug development--its stages, nonclinical safety evaluation, toxicokinetics, toxicologic pathology and routine and special techniques, principles of clinical pathology, toxicogenomics, and spontaneous lesions in control animals used in toxicity studies--then address pathological changes related to toxicity in each organ system, and their implications in the drug development process. Light microscopic and electron microscopic descriptions of lesions, differential diagnoses, biological consequences, pathogenesis, mechanisms of lesion formation, and the expected clinical pathology correlates are described.

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Publication:Reference & Research Book News
Article Type:Brief article
Date:Jun 1, 2013
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