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Tourette Syndrome: Genetics, Neurobiology and Treatment.

CHASE, T N., FRIEDHOFF, A. J., & COHEN, D. J. (Eds.). Tourette Syndrome: Genetics, Neurobiology and Treatment. Raven Press, 1 992. Pp. xix + 377.

In this 58th volume in the series Advances in Neurology, the editors have done a superb job of selecting 41 chapters that reveal how "Tourette's syndrome has served, throughout its history, as a testing ground for new ideas about the relations between mind and body in neurological and developmental psychopathological conditions" (p. xv). The chapters are organized into eight sections dealing with clinical phenomenology, epidemiology, comorbid conditions, neurochemistry and neuropathology, genetics, neuroimaging, pharmacological treatments, and nonpharmacological interventions, as well as a final perspective section written by the editors with an additional participant. All of the chapters were superbly written, and a few stand out as shining exemplars of excellent scholarship. In particular, Fallon and Schwab-Stone wrote an excellent Chapter 6, in which they discussed major methodological issues in epidemiological studies of tics and comorbid psychopathology. In Chapter 23, Comings and Comings cleverly present a host of alternative hypotheses that counter assumptions made by many of those who research the inheritance of Tourette's Syndrome. Psychopharmacologists will be particularly impressed by the eight separate chapters that provide rigorous evaluation of drug treatments. Finally, the closing chapter on "Perspectives: Research and Treatment" provides an easy-to-grasp investigation into the implications of the results and discussions of the past 40 chapters. This final chapter is a superb conclusion to this excellent book. Perhaps those who emphasize social factors in the etiology and treatment of Tourette's Syndrome may feel that the text is too generous in giving so much space to studies of genetics, neuroimaging, neurochemistry, neuropathology, and drug treatment, Fortunately, there are a number of chapters on nonpharmacological treatment of the syndrome (including consideration of educational management, family therapy, and behavior therapy), chapters in the section on drug treatment include consideration of dietary interventions, and the overwhelming majority of the chapter authors take to heart the concise and impressive suggestions of Felton Earls, who in Chapter 7 explored the importance of psychosocial factors in Tourette's Syndrome. This text would thus be of great value to any scientist or researcher interested in any aspect of this complex and fascinating psychopathology. (Arthur P. Leccese, Kenyon College)
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Author:Leccese, Arthur P.
Publication:The Psychological Record
Article Type:Book Review
Date:Mar 22, 1993
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