Topical composition from Dr. Reddy's.
* US Patent No. 8,431,140 B2; Dr. Reddy's Laboratories, Inc.,
Bridgewater, NJ, and Reddy's Laboratories, Ltd., Hyderabad, India,
have patented a single phase topical pharmaceutical composition. It
contains a biologically active agent selected from the group consisting
of terbinafine, naftifine, amorolfine, butenafine, derivatives thereof,
salts thereof, or combinations thereof; a delivery vehicle comprising a
non-polymeric crystallization inhibitor that is capable of delaying
crystallization of the biologically active agent, and a film-former; a
volatile solvent in an amount selected to create a subsaturated solution
of said biologically active agent; and water. The biologically active
agent attains a supersaturated state upon evaporation of the volatile
solvent upon said administration.