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Top Biopharma products of 2013.

While debate continues over biosimilars approval pathways in the U.S., it is easy to forget that a number of biosimilars and biobetters are already out there. Here is a list of 2013's Top Biopharma products, including, where relevant, the total number of biosimilar and biobetter versions of these drugs, from biopharma.com.

Rank   Trade Name U.S.     Marketer

1      Humira              Abbott
2      Remicade            J&J
3      Rituxan             Roche Genentech
4      Enbrel              Amgen
5      Lantus              Sanofi
6      Herceptin           Roche Genentech
7      Avastin             Roche Genentech
8      Neulasta            Amgen
9      Lucentis            Roche Genentech
10     Prevnar 13          Pfizer
11     Epogen/Procrit      Amgen; J&J
12     NovoLog             Novo Nordisk
13     Avonex              Biogen IDEC
14     Humalog             Lilly
15     Rebif               Merck KGaA
16     Pegasys             Roche
17     Aranesp             Amgen
18     Advate              Baxter
19     Victoza             Novo Nordisk
20     Levemir             Novo Nordisk
21     Novolin             Novo Nordisk
22     Botox               Allergan
23     Erbitux             BMS
24     Eylea/Zaltrap       Regeneron
25     Gardasil            Merck & Co.
26     Tysabri             Biogen IDEC
27     Kogenate FS/        Bayer
         Helixate FS
28     NovoSeven           Novo Nordisk
29     Soliris             Alexion
30     Neupogen            Amgen
31     Simponi             J&J
32     Xolair              Roche Genentech
                             & Novartis
33     Stelara             J&J
34     Betaseron           Bayer
35     Orencia             BMS
36     Infanrix            GSK
37     Humulin             Lilly and Roche
38     Actemra             Roche
39     Forteo              Lilly
40     Nordi tropin        Novo Nordisk
41     Synagis             AstraZeneca
42     Yervoy              BMS
43     Cerezyme            Genzyme
44     BeneFIX             Pfizer
45     Cimzia              UCB Group
46     Gonal-f             Merck KGaA
47     Fluzone             Sanofi
48     TNKase              Roche Genentech
49     Genotropin          Pfizer
50     Xgeva               Amgen
51     Lumizyme/ Myozyme   Genzyme
52     Synflorix           GSK
53     Pulmozyme           Roche Genentech
54     Zostavax            Merck & Co.
55     Pneumovax 23        Merck & Co.
56     Xyntha              Pfizer
57     RotaTeq             Merck & Co.
58     Activase            Roche Genentech
59     NeoRecormon         Roche
60     Humate-P            CSL
61     Elaprase            Shire
62     Fabrazyme           Genzyme
63     Synvisc             Genzyme
64     Menactra            Sanofi
65     Sylatron/           Merck & Co.
         PEG-Intron
68     Follistim AQ        Merck & Co.
69     Replagal            Shire
70     NPLATE              Amgen
71     Nutropin AQ         Roche Genentech
72     Apidra              Sanofi
73     Humatrope           Lilly

Rank   Name                                     Sales 2013

1      TNF Mab, rDNA, human                      $10,659
2      TNF Mab, rDNA                              $8,944
3      CD20 Mab, rDNA                             $8,583
4      TNF Receptor-IgG Fc, rDNA                  $8,325
5      Insulin glargine, rDNA                     $7,767
6      HER2 receptor Mab, rDNA                    $6,930
7      VEGF Mab, rDNA                             $6,745
8      G-CSF, rDNA, PEG                           $4,390
9      VEGF Mab Fab, rDNA                         $4,205
10     Pneumococcal Vaccine(13)--CRM197           $4,000
11     EPO, rDNA                                  $3,400
12     Insulin aspart, rDNA                       $3,135
13     Interferon beta-la, rDNA                   $3,005
14     Insulin lispro, rDNA                       $2,611
15     Interferon beta-la, rDNA                   $2,589
16     Interferon alfa-2a, rDNA, PEG-             $2,500
17     EPO, darbo-, rDNA                          $2,420
18     Factor VIII, rDNA, PFM                     $2,368
19     Glucagon-like peptide-1, rDNA              $2,071
20     Insulin detemir, rDNA                      $2,055
21     Insulin, rDNA                              $2,020
22     Botulinum Toxin A                          $1,980
23     EGF receptor Mab, chimeric, rDNA           $1,920
24     VEGF Trap, rDNA                            $1,851
25     HPV vaccine, rDNA                          $1,831
26     Integrin Mab, rDNA                         $1,700
27     Factor VIII, rDNA                          $2,160

28     Factor Vila, rDNA                          $1,648
29     Complement C5 Mab, rDNA                    $1,550
30     G-CSF, rDNA                                $1,520
31     TNF Mab, rDNA, human                       $1,520
32     Immunoglobulin E Mab, rDNA                 $1,510

33     IL-12/23 Mab, rDNA                         $1,500
34     Interferon betaser, rDNA                   $1,440
35     CTLA4-Ig, rDNA                             $1,440
36     DTaP Vaccine                               $1,300
37     Insulin, rDNA                              $1,239
38     Interleukin-6 receptor Mab, rDNA           $1,180
39     Parathyroid hormone (1-34), rDNA           $1,151
40     Somatropin, rDNA                           $1,140
41     RSV Mab, rDNA                              $1,060
42     CTLA-4 Mab, rDNA                            $960
43     Glucocerebrosidase, rDNA                    $945
44     Factor IX, rDNA                             $832
45     TNF Mab Fab', rDNA, PEG-                    $820
46     FSH rDNA                                    $814
47     Influenza Vaccine                           $800
48     tPA, TNK-, rDNA                             $780
49     Somatropin, rDNA                            $775
50     RANKL Mab, rDNA                             $745
51     Glucosidase, rDNA                           $695
52     Pneumococcal Vaccine-HiD                    $677
53     DNase, rDNA                                 $655
54     Varicella Virus Vaccine, adult              $651
55     Pneumococcal Vaccine                        $650
56     FactorVIII, rDNA, new                       $602
57     Rotavirus Vaccine, live                     $601
58     tPA, rDNA                                   $600
59     EPO, rDNA                                   $595
60     Factor VIILvWF                              $550
61     Iduronate-2-sulfatase, rDNA                 $546
62     Galactosidase, alpha/ rDNA                  $530
63     Hyaluronic acid                             $510
64     Meningococcal Conjugates Vaccine $496
65     Interferon alfa-2b, rDNA, PEG-              $495

68     FSH rDNA                                    $480
69     Galactosidase, alfa, rDNA                   $470
70     Thrombopoietin peptibody, rDNA $450
71     Somatropin, rDNA                            $395
72     Insulin glulisine, rDNA                     $376
73     Somatropin, rDNA                            $360

       Biosimilars   Biobetters
        for this      for this
Rank     Product      Product

1          20            7
2          12            8
3          43            18
4          26            11
5           7            5
6          37            14
7          21            9
8          19            10
9           2            3
10          0            0
11         61            22
12          2            0
13          2            4
14          5            3
15          1            4
16          2            7
17          5            2
18          0            5
19          2            5
20          0            0
21         19            41
22          2            7
23         12            14
24          0            0
25          0            0
26         2 1
27          1            0

28          9            13
29          0            0
30         56            15
31          3            5
32          2            2

33          2            3
34          8            4
35          5            3
36          0            0
37         20            41
38          2            6
39          7            8
40          1            0
41          6            2
42          1            1
43          2            2
44          0            14
45          0            0
46         11            6
47          0            0
48          1            0
49          1            0
50          2            0
51          1            2
52          0            0
53          0            1
54          0            0
55          0            0
56          0            1
57          0            0
58          0            2
59          1            0
60          0            0
61          0            2
62          1            0
63          2            0
64          0            0
65          4            6

68         10            5
69          5            0
70          0            0
71          0            0
72          0            0
73          3            0

RONALD A RADER is a consultant and the author and publisher
of Biopharma: Biopharmaceutical Products in the U.S. and
European Markets (www,bio-pharma.com), based in Rockville,
MD. Mr. Rader may be contacted at biotech@biopharma.com.
COPYRIGHT 2014 Rodman Publishing
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2014 Gale, Cengage Learning. All rights reserved.

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Author:Rader, Ronald A.
Publication:Contract Pharma
Date:Jul 1, 2014
Words:974
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