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Tolerance by process of elimination?

Tolerance by process of elimination?

Exactly how the immune system recognizes substances fromoutside the body as foreign is a mystery immunologists would like to solve. Scientists have hypothesized that groups of T cells potentially capable of reacting with substances in the body are either eliminated early in their development or prevented in some way from becoming activated after maturation.

Recent evidence from scientists at the University of ColoradoHealth Sciences Center and the National Jewish Center for Immunology and Respiratory Medicine in Denver supports the clonal elimination theory, according to two reports in the April 24 CELL. Using monoclonal antibodies, the researchers measured T cell concentrations of surface receptors for a protein crucial in antigen recognition processes. They found that T cells with the receptor are selectively removed from the body's T cell pool early, in a process that may take place while the lymphocytes are maturing in the thymus.
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Title Annotation:research on how the immune system recognizes substances from outside the body
Publication:Science News
Date:May 16, 1987
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