Tim is out to whip Greg.
The British number one, seeded fifth here, cruised through yesterday when outclassing Lars Burgsmuller 6-3 6-4.
Rusedski had earlier claimed his first victory on clay in the best part of four years when he overcame the challenge of another German, wildcard Philipp Petzschner, 7-6 3-6 6-3.
Henman and Rusedski have met eight times before on the ATP Tour, with the former holding a 6-2 advantage.
Rusedski did push his old rival all the way before going down 4-6 7-6 6-4 in Dubai earlier this year, but you have to go back to 1998 for his last win over Henman.
"It always adds some extra spice when I play against Greg, but I feel confident and I have been playing some really good tennis," said Henman.
The 30-year-old from Oxford never reached top gear in cold, damp conditions yesterday, but he always appeared in control of the match ( winning the majority of the baseline encounters and looking at home on the clay surface.
"I felt the conditions were really tough," Henman said. "You've got to be positive in your mind, not let things upset you too much."
Rusedski secured his first win on clay since the 2001 French Open, and immediately expressed a desire to avenge his Dubai defeat to Henman.
He said: "I had two match points last time and should have won. It should be a great match."
American second seed Andy Roddick crashed out to Nicolas Massu of Chile 7-6 4-6 7-5.
US Open champion Svetlana Kuznetsova has confirmed that she will defend her Hastings Direct International Championships title in Eastbourne from June 13-19.
The world number seven, who beat Danielle Hantuchova in last year's final, said: "I am really looking forward to going back."