Printer Friendly

Thyrotropin releasing hormone does not condition taste aversion.

1. THYROTROPIN RELEASING HORMONE DOES NOT CONDITION TASTE AVERSION.

Recently, we demonstrated that administration of thyrotropin releasing hormone (TRH) reduces alcohol consumption and preference in rats. We determined if this effect represents a response to nausea or illness induced by TRH injection by employing the conditioned taste aversion test. Twenty-four female and male rats (Ns=12) were water deprived and given 30 min access to water daily until intakes stabilized. Rats were then given 30 min access to 0.1% w/v sodium saccharin, followed immediately by intraperitoneal injection of either saline (N=6), lithium chloride (N=6), or 20 or 40 mg/kg of TRH (Ns=6). This procedure was repeated three times, with only water available for 30 min and no injections on alternate days. Saccharin solution consumption was measured for a total of 7 test days. LiCl injection caused a significant (p<0.05), sharp and persistent decline in saccharin intake, but the other injections did not. These data are consistent with the hypothesis that TRH does not reduce alcohol intake by an aversive mechanism. The possibility remains that TRH, released by alcohol, may function endogenously as a non-aversive neuropeptide regulator of alcohol consumption and preference.

Karen A. Alvarado * and Paul J. Kulkosky *. Department of Psychology, University of Southern Colorado.

* Denotes membership in the Colorado-Wyoming Academy of Science.
COPYRIGHT 2001 Colorado-Wyoming Academy of Science
No portion of this article can be reproduced without the express written permission from the copyright holder.
Copyright 2001 Gale, Cengage Learning. All rights reserved.

Article Details
Printer friendly Cite/link Email Feedback
Author:Alvarado, Karen A.; Kulkosky, Paul J.
Publication:Journal of the Colorado-Wyoming Academy of Science
Article Type:Brief Article
Geographic Code:1USA
Date:Apr 1, 2001
Words:221
Previous Article:The Colorado-Wyoming Academy of Science.
Next Article:Stereochemical study of the reduction of Acetophenone.
Topics:


Related Articles
Low TSH: an early warning for stroke.
Learn to answer troublesome questions about thyroid tests.
Forbidden flavors: scientists consider how disgusting tastes can linger surreptitiously in memory.
Hormone dulls a tongue's taste for sweets.
Fat as a taste: modifying behavior in rats with linoleic acid. (South Carolina Junior Academy Of Sciences Abstracts).
Claret cure: drink two glasses of red wine and call me in the morning.
Diffuse hyperplasia of the thyroid gland (Graves' disease).
Radiotherapy-associated euthyroid Graves ophthalmopathy following floor-of-mouth surgery: a case report.

Terms of use | Privacy policy | Copyright © 2019 Farlex, Inc. | Feedback | For webmasters