Thyrotropin releasing hormone does not condition taste aversion.
Recently, we demonstrated that administration of thyrotropin releasing hormone (TRH) reduces alcohol consumption and preference in rats. We determined if this effect represents a response to nausea or illness induced by TRH injection by employing the conditioned taste aversion test. Twenty-four female and male rats (Ns=12) were water deprived and given 30 min access to water daily until intakes stabilized. Rats were then given 30 min access to 0.1% w/v sodium saccharin, followed immediately by intraperitoneal injection of either saline (N=6), lithium chloride (N=6), or 20 or 40 mg/kg of TRH (Ns=6). This procedure was repeated three times, with only water available for 30 min and no injections on alternate days. Saccharin solution consumption was measured for a total of 7 test days. LiCl injection caused a significant (p<0.05), sharp and persistent decline in saccharin intake, but the other injections did not. These data are consistent with the hypothesis that TRH does not reduce alcohol intake by an aversive mechanism. The possibility remains that TRH, released by alcohol, may function endogenously as a non-aversive neuropeptide regulator of alcohol consumption and preference.
Karen A. Alvarado * and Paul J. Kulkosky *. Department of Psychology, University of Southern Colorado.
* Denotes membership in the Colorado-Wyoming Academy of Science.
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|Author:||Alvarado, Karen A.; Kulkosky, Paul J.|
|Publication:||Journal of the Colorado-Wyoming Academy of Science|
|Article Type:||Brief Article|
|Date:||Apr 1, 2001|
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