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Therapeutic applications of RNAi; methods and protocols.


Therapeutic applications of RNAi; methods and protocols.

Ed. by John F. Reidhaar-Olson.

Humana Press Inc.


148 pages



Methods in molecular biology, 555


RNA interference, RNAi, has quickly become a standard tool in the drug discovery process because it can prevent the expression of pretty much any gene in the mammalian genome. Specialist researchers here describe laboratory methods for investigating possible therapeutic applications of the process and its products. Among their topics are targeted gene silencing in solid tumors with electrically mediated siRNA delivery, silencing virus replication, RNAi in the malaria vector Anopheles gambiae, lentiviral and adeno-associated vector-based therapy for motor neuron disease through RNAi, studying autoimmunity by in-vitro RNA interference, and alternative splicing as a therapeutic target for human diseases.

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Publication:SciTech Book News
Article Type:Book review
Date:Dec 1, 2009
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