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The sticky synapse; cell adhesion molecules and their role in synapse formation and maintenance.


The sticky synapse; cell adhesion molecules and their role in synapse formation and maintenance.

Ed. by Michael Hortsch and Hisashi Umemori.



453 pages




Neural cell adhesion molecules are important both for their role they play in the genesis and maintenance of synaptic connections, and therefore the understanding of neurological disorders and psychiatric conditions, and for their postulated role in the evolution of the human brain. Hortsch (cell and developmental biology, U. of Michigan) and Umemori (biological chemistry, U. of Michigan Medical School) present 21 papers summarizing the current state of knowledge concerning these molecules and their role in synaptic conditions. Topics include cell adhesion molecules at the Drosophilia neuromuscular junction, synapse formation in the mammalian central nervous system, developmental axonal pruning and synaptic plasticity, cell adhesion molecules in synatopathies, the cadherin superfamily in synapse formation and function, nectins and nectin-like molecules in the nervous system, the Down syndrome cell adhesion molecule, molecular basis of lamina-specific synaptic connections in the retina, cell adhesion molecules of the NCAM family and their roles at synapses, ephrins and eph receptor tyrosine kinases in synapse formation, the role of integrins at synapses, and extracellular matrix molecules in neuromuscular junctions and central nervous system synapses.

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Publication:SciTech Book News
Article Type:Book review
Date:Dec 1, 2009
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