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The role of cytokines in the pathophysiology of chronic tonsillitis.

Chronic tonsillitis is characterized by recurrent and persistent infections of palatine tonsils. Tonsillar hypertrophy is a process characterized by the palatine tonsil hypertrophy, which is not always accompanied by the infective process. These two diseases are developed by different pathophysiological mechanisms at the same tissue. Many different chemokines' role was studied in the chronic tonsillitis. We aimed to show the expressions of IL-1 [alpha] and [beta], IL-6, IL-8, IL-15 and TNF [alpha] in the chronic inflamed tonsil tissue. The study was conducted at Baskent University Departments of Otorhinolaryngology and Medical Genetics. Total 45 samples obtained from tonsillectomy due to chronic tonsillitis (17) or tonsillar hypertrophy (28) were participated in the study. The expression levels of cytokines were determined via Real Time Polymerase Chain Reaction (RT-PCR) technique and comparison was made between the tissue groups. We only found statistically difference in the expression of IL-8. The mean expression level of IL-8 was higher in hypertrophy group. It may be related to increased number of germinal centers in hypertrophy group. We did not find any statistically difference in the expression levels of IL-1 [alpha] and IL-6, IL-15 and TNF [alpha]. New studies searching these or other cytokines may guide us to find the difference between hypertrophy and chronic inflammation.

Seda Turkoglu Babakurban (1), Selin Akad (2), Yunus Kasim Terzi (2), Selim Sermed Erbek (1), Feride Iffet Sahin (2)

(1) Department of Otorhinolaryngology, Baskent University Faculty of Medicine, Ankara, Turkey

(2) Department of Medical Genetics, Baskent University Faculty of Medicine, Ankara, Turkey

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Title Annotation:OP-23-008
Author:Babakurban, Seda Turkoglu; Akad, Selin; Terzi, Yunus Kasim; Erbek, Selim Sermed; Sahin, Feride Iffet
Publication:Erciyes Medical Journal
Date:Jun 1, 2019
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