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The expression of g-protein coupled receptor-64 in mice dorsal root ganglia.

THE EXPRESSION OF G-PROTEIN COUPLED RECEPTOR-64 IN MICE DORSAL ROOT GANGLIA. Phillip P. Nguyen and Mark Ledoux, Christian Brothers University, Memphis, Tennessee, and University of Tennessee Health Science Center, Memphis, Tennessee. In order to better our understanding of neuropathy, we need to pay a close attention to the specific genes that manifested in a particular disease. According to a previous study by LeDoux and colleagues, a significant expression of G-protein coupled receptor-64 was identified in mice dorsal root ganglia. This led to the present study, which focused on comparing the expression of the G-protein coupled recepto-64 in type A and type B ganglion cells. The type A cell is larger and gives rise to A[alpha] and A[beta] fibers, while the type B cell is smaller and gives rise to A[sigma] and C fibers. Mice were perfused with saline followed byparaformaldehyde, and the spinal cord was removed and placed in sucrose solution. Ganglia were collected and sectioned at 10-[micro]m using a cryostat. Immuno-staining was used to identify the protein expression on the two cell types. The results suggested that type B ganglion cells have a higher protein expression than type A ganglion cells.
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Title Annotation:WESTERN REGION
Author:Nguyen, Phillip P.; Ledoux, Mark
Publication:Journal of the Tennessee Academy of Science
Article Type:Report
Geographic Code:1USA
Date:Jul 1, 2008
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