The critical impact of controlled drug delivery in the future of tissue engineering.
Tissue engineering is known as a newly emerged strategy to repair and regenerate the injured or deficient tissues through natural, synthetic biodegradable porous constructs as scaffolds. The combination of biomaterials, cells, and biological molecules to induce differentiation signals to promote tissue repair is shown in tissue engineering as a promising therapeutic approach . The combination of tissue engineering and controlled drug delivery has been shown as an effective strategy for locally controlling the dose and duration of the release of biological molecules . Indeed, dual application of biodegradable polymers as a porous substrate for cell adhesion, proliferation and differentiation and also as a controlled drug release system for the local tissue has led to be a valuable achievement in both tissue engineering and drug delivery aspects. Transferring active pharmaceutical ingredients to the site defects in the body by biodegradable polymeric nanocarriers, owning their unique physicochemical properties is the goal of this approach . These therapeutic nanoparticles have the potential to revolutionize the drug development process and change the landscape of tissue engineering and regenerative medicine [17-21]. Application of polymeric carriers in nano size has led to develop a new achievement to better control on different types of biological molecules such as hydrophilic drugs, hydrophobic drugs, antibiotics, growth factors, proteins, and nucleic acids . In addition, many factors such as the physicochemical properties of the nanoparticles, morphological characteristics, type of the defected tissues, the rate of blood flow, and vascular supply, play critical roles in determining the effectiveness of this strategy . In order to revolutionize the delivery mechanisms of biological molecules to the targeted tissues or organs, development of highly improved nanocarriers with enhanced biocompatibility and biodegradability properties is needed .
There have been several attempts to generate new treatments for defected tissues. Many tissue engineering strategies have been proposed but the field is still in its fancy stages and needs further developments. This note suggested a major strategy for creating the next generation of scaffold constructs along with the approaches taken to incorporate biological molecules within the nanoparticles and the benefits of combining tissue engineering and drug delivery.
Bioengineering Research Group, Nanotechnology and Advanced Materials Department, Materials and Energy Research Center (MERC), P.O. Box 14155-4777, Tehran, Iran E-mail: firstname.lastname@example.org
Received 18 June 2014; Accepted 19 June 2014; Available online 1 July 2014
[1.] Biondi, M., Ungaro, F., Quaglia, F., Netti, P.A., Controlled drug delivery in tissue engineering, Advanced Drug Delivery Reviews, 2008;60 (2), pp. 229-242
[2.] DocumentShi, J., Votruba, A.R., Farokhzad, O.C., Langer, R., Nanotechnology in drug delivery and tissue engineering: From discovery to applications, Nano Letters, 2010;10 (9), pp. 3223-3230
[3.] Williams J, Lansdown R, Sweitzer R, et al. Nanoparticle drug delivery system for intravenous delivery of topoisomerase inhibitors. J Control Release 2003;91:167-72.
[4.] LerouxJ-C, Allemann E, De Jaeghere F, Duelker E, Gurny R. Biodegradable nanoparticles-From sustained release formulation to improved site specific drug delivery. J Control Release 1996;30:339-50.
[5.] Ringdorf H. Structure and properties of pharmacologically active polymers. J Polym Sci Symp 1975; 51:135-53.
[6.] Helder A. Santos, Porous-based biomaterials for tissue engineering and drug delivery applications, Biomatter 2012; 2:237-238.
[7.] Moreno-Vega A., Gomez-Quintero T., Nunez-Anita R., Acosta-Torres L., Castano V., Polymeric and Ceramic Nanoparticles in Biomedical Applications, J. Nanotech., Article ID 936041, (2012) doi:10.1155/2012/936041
[8.] Daniel S Kohane ,Robert Langer, Polymeric Biomaterials in Tissue Engineering , Pediatric Research (2008) 63, 487-91.
[9.] Raphael Riva, Heloyse Ragelle, Anne des Rieux, Nicolas Duhem, Christine Jerome, and Veronique Preat, Chitosan and Chitosan Derivatives in Drug Delivery and Tissue Engineering, AdvPolymSci (2011) 244: 19-44.
[10.] Jalali N., Moztarzadeh F., Mozafari M., Asgari S., Motevalian M., Alhosseini S.N., Surface modification of poly(lactide-co-glycolide) nanoparticles by d-[alpha]-tocopheryl polyethylene glycol 1000 succinate as potential carrier for the delivery of drugs to the brain, Colloids and Surfaces A: Physicochemical and Engineering Aspects, 392 (2011) 335-342.
[11.] Langer R., Biomaterials in drug delivery and tissue engineering: one laboratory's experience, Acc Chem Res. 33 (2000) 94-101.
[12.] Hakkarainen, M., Aliphatic polyesters: abiotic and biotic degradation and degradation products, Adv. Polym. Sci., 2002, 157, 113.
[13.] Vert, M., Li, S., Garreau, H., AJ. More about the degradation of LA/GA-derived matrices in aqueous media,Control. Release., 1991, 16, 15.
[14.] Park JH, Saravanakumar G et al (2010) Targeted delivery of low molecular drugs using chitosan and its derivatives. Adv Drug Deliv Rev 62:28-41.
[15.] Patricia B. Malafaya, Gabriela A. Silva, Rui L. Reis, Natural-origin polymers as carriers and scaffolds for biomolecules and cell delivery in tissue engineering applications, Advanced Drug Delivery Reviews 59 (2007) 207-233.
[16.] Jalali N., Moztarzadeh F., Mozafari M., Asgari S., Motevalian M., Alhosseini S.N., Chitosan-surface modified poly(lactide-co-glycolide) nanoparticles as an effective drug delivery system, 18th Iranian Conference on Biomedical Engineering (IEEE), 14-16 December, 2011, Tehran, Iran.
[17.] Allen TM, Cullis PR, Drug delivery systems: entering the mainstream. Science,2004;303:1818-1822.
[18.] Mozafari M., Functional nanomaterials for advanced tissue engineering, Editor: M. Aliofkhazraei, in Handbook of Functional Nanomaterials Volume 4 Properties and Commercialization, NOVA Science Publishers Inc., New York, USA (2013).
[19.] K. Nazemi, F. Moztarzadeh, N. Jalali, S. Asgari, M. Mozafari, Synthesis and characterization of poly(lactic-co-glycolic) acid nanoparticlesloaded chitosan/bioactive glass scaffolds as a localized delivery system in the bone defects, Biomed Research International, 2014 (2014) 1-9.
[20.] Petros RA, DeSimone JM, Strategies in the design of nanoparticles for therapeutic applications. Nat Rev Drug Discov2010;9(8):615-627 .
[21.] Shi J, Votruba AR, Farokhzad OC, Langer R (2010) Nanotechnology in drug delivery and tissue engineering: from discovery to applications. Nano Lett 10(9):3223-3230 .
[22.] Danhier, F., Ansorena, E., Silva, J.M., Coco, R., Le Breton, A., Preat, V., J. Control. Release, 2012, 161, 205.
[23.] Sun C, Lee JSH, Zhang MQ. Magnetic nanoparticles in MR imaging and drug delivery. Adv Drug Deliv Rev 2008;60:1252-65.
[24.] Christine T. Schwall and Ipsita A. Banerjee, Micro- and Nanoscale Hydrogel Systems for Drug Delivery and Tissue Engineering, Materials 2009;2:577-612.
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|Publication:||Trends in Biomaterials and Artificial Organs|
|Date:||Jul 1, 2014|
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