The Role of [.sup.18]F-FDG PET/CT in Detecting Ovarian Cancer Recurrence in Patients with Elevated CA-125 Levels/CA-125 Duzeylerinde Artis Olan Over Kanserli Hastalarda Rekurrens Saptamada [.sup.18]F-FDG PET/BT'nin Rolu.
Ovarian cancer is the fourth leading cause of cancer death among women (1). It is usually diagnosed at advanced stages thus having poor prognosis. In spite of effective treatment and complete response, recurrence may occur in 50-80% of these patients (2,3,4). Early detection of recurrence is important for patient management.
CA-125 is a high-molecular weight glycoprotein that is expressed at the cell-surface of epithelial cells. Serum CA-125 levels are the reference method for the detection of ovarian carcinoma recurrences with a very high positive predictive value (PPV). Nevertheless, CA-125 is not specific for ovarian cancer in addition to not being sensitive especially for small-volume disease (5,6).
[.sup.18]F-FDG positron emission tomography/computed tomography (PET/CT) is a noninvasive, highly accurate imaging method both in staging and in follow-up of many cancers including ovarian cancer. [.sup.18]F-FDG PET/CT has a very high sensitivity rate (85-100%) for detection of recurrence in ovarian cancer (7).
The aim of this retrospective study is to investigate the role of [.sup.18]F-FDG PET/CT in detection of recurrence in ovarian cancer patients with increased CA-125 levels.
Materials and Methods
All patients who underwent [.sup.18]F-FDG PET/CT for restaging due to high CA-125 levels (N: 0-35 U/mL) from March 2013 to December 2016 were retrospectively evaluated. A total of 52 patients (30-80 years; mean 58.5[+ or -]10.6) were analyzed in two different institutions. All patients had undergone surgery (3-94 month ago) and chemotherapy or radiotherapy prior to PET/CT imaging. [.sup.18]F-FDG PET/CT findings were compared with histopathological, radiological and clinical follow-up findings in at least 6 months.
The Local Ethics Committee of Adnan Menderes University approved the study (protocol number: 2018/1487, date: 27.09.2018).
[.sup.18]F-FDG PET/CT Imaging
All patients' fasting blood sugar levels were less than 180 mg/dL prior to imaging. After intravenous administration of 270-370 MBq (7.3-10 mCi) [.sup.18]F-FDG, patients rested in a quiet room. Oral contrast was given to all patients. [.sup.18]F-FDG PET/CT imaging was performed after a resting period of 60 minutes by using Siemens (Biograph mCT 20) and General Electric (GE, Discovery 610) PET/CT scanners. The CT scan data were collected at 120 kV and 50 mAs. The PET acquisitions were obtained from the head to the midthighs at the rate of 2 minute per frame.
All [.sup.18]F-FDG PET/CT imaging were evaluated visually and semi-quantitatively by two nuclear medicine physicians. For semi-quantitative evaluation, maximum standardized uptake values ([SUV.sub.max]) were calculated for all pathological lesions. The lesions with a [SUV.sub.max][greater than or equal to]2.5 at the site of pathologic changes on CT imaging were accepted as malignant lesions.
PET/CT findings were compared with histopathologic findings (n=10) and serial conventional imaging methods and/or clinical follow-up results (n=42). If the lesion could not be histopathologically confirmed then those with decreased CA-125 levels following ovarian cancer treatment (chemotherapy or radiation therapy) and/or lesions verified by serial imaging methods including PET/CT were accepted as true positive (TP). If PET/CT findings were normal and no recurrence was detected during serial imaging or clinical follow-up then the result was classified as true negative (TN). If PET/CT findings were normal but recurrence was detected by serial imaging methods or clinical follow-up, then the results were defined as false negative (FN). Positive PET/CT results that were proved to be benign or due to a secondary malignancy were classified as false positive (FP). Patients who had both TP and FP findings were classified as TP in the patient based analysis.
The sensitivity, specificity, PPV and negative predictive values (NPV) and accuracy were calculated by standard statistical formulas.
A total of 52 patients with a diagnosis of ovarian cancer were included in the study. The main tumor type was serous carcinoma/adenocarcinoma (n=39, 75%), followed by clear cell carcinoma (n=3, 6%), endometroid carcinoma (n=3, 6%), mucinous carcinoma (n=3, 6%), undifferentiated carcinoma (n=2, 4%), granulosa cell tumor (n=1, 2%) and primitive neuroectodermal tumor (n=1, 2%). CA-125 levels ranged between 35.2-2740 U/mL (mean 341[+ or -]564 U/mL). [.sup.18]F-FDG PET/CT detected a hypermetabolic nodular lesion in the lung suggesting metastasis in one patient. Serial contrast-enhanced CT scans did not reveal any nodule following non-specific treatment and CA-125 levels also decreased, therefore, the PET/CT result was accepted as FP.
There were 3 FN results in the study: In one patient there was a hypometabolic cystic lesion on pelvic images but CA-125 levels decreased after chemotherapy (patient no: 8). In another patient PET/CT imaging did not show any lesions except mildly hypermetabolic ([SUV.sub.max]: 2.7) millimetric lymph nodes with benign appearance in the mediastinum suggesting reactive enlargement, however, serial PET/CT imaging detected progression and CA-125 levels increased progressively (patient no: 17). In the third patient, PET/CT imaging did not reveal any hypermetabolic lesions but serial CT imaging detected local recurrence (patient no: 40). In this patient, recurrence was confirmed by biopsy during follow-up.
Fourteen distant metastasis were detected correctly in 12 patients on [.sup.18]F-FDG PET/CT imaging (8 of them liver, 2 bone, 2 lung, one pleura, and one brain metastasis). Two patients with positive [.sup.18]F-FDG PET/CT findings are illustrated in Figures 1, 2.
According to patient-based analysis; the sensitivity, specificity, PPV, NPV and accuracy of [.sup.18]F-FDG PET/CT in detecting ovarian cancer recurrence in patients with elevated CA-125 levels were calculated as 94%, 75%, 98%, 50% and 96%, respectively.
Detailed results of PET/CT imaging and final diagnosis of all patients are shown in Table 1.
The patients were divided into two different groups as those with CA-125 elevation less than 100 U/mL (n=22) and those with [greater than or equal to]100 U/mL (n=30). The sensitivity and specificity rates of PET/CT imaging according to CA-125 levels are shown in Table 2. Because there is no TN result in patients with CA-125 levels [greater than or equal to]100, specificity could not be calculated in this group.
Early detection of tumor recurrence is important in ovarian cancer patients due to its close relation with prognosis and the choice of appropriate treatment. Even after effective treatment and complete response, the recurrence rate is 50-80% in these patients (2,3,4,8).
In addition to clinical examination and imaging modalities, CA-125 measurements are also used for monitoring disease progression in patients with ovarian cancer. Nevertheless, several benign diseases such as infections may cause elevation in CA-125, and it is not reliable in detecting disease recurrence due to its high FN results (6,9). In this study, the patient with a TN finding had an infection at the operation site and the high CA-125 level was attributed to this infection.
Although, CT and magnetic resonance imaging (MRI) are the most commonly used imaging methods to detect recurrent ovarian cancer; their contribution is limited in small-volume recurrent lesions or metastatic deposits on visceral surfaces. CT has low sensitivity (25-50%) for detection of peritoneal metastases smaller than 1 cm (7,10).
[.sup.18]F-FDG PET/CT has been shown to be superior to CT and MRI in detection of recurrent ovarian cancer. It might specify recurrent ovarian cancer approximately 6 months prior to CT (11). In a meta-analysis, the authors evaluated diagnostic performance of CA-125, PET, PET/CT and MRI in 34 recurrent ovarian cancers, and they reported that CA-125 had the highest specificity (93%) while PET/CT had the highest sensitivity (91%). They also showed that diffusion weight MRI is showing promise in detecting small volume peritoneal disease and may be used complementary to PET. The pooled sensitivity and specificity did not show any statistical significance between PET alone and PET/CT in this study (12).
The reported sensitivity and specificity of [.sup.18]F-FDG PET/CT imaging ranged from 80-100% and 42%-100%, respectively, in detecting recurrent disease (4,7,13,14). Fagotti et al. (15) reported the sensitivity, specificity, NPV, PPV, and accuracy of [.sup.18]F-FDG PET/CT in recurrent ovarian cancer as 93.0%, 55.6%, 83.3%, 76.9% and 78.6%, respectively. In the same study, authors reported the sensitivity, specificity, PPV, NPV and accuracy rates for laparoscopy as 95%, 64%, 80.8%, 88.9% and 83.1%, respectively (15). In another study, Sari et al. (16) investigated the role of [.sup.18]F-FDG PET/CT in recurrent ovarian cancer with high tumor markers or suspicious lesions on CT and they reported the sensitivity, specificity and accuracy of PET/CT as 96.1%, 100% and 97%, respectively.
In this study, sensitivity, specificity, PPV, NPV and accuracy of [.sup.18]F-FDG PET/CT in detecting ovarian cancer recurrence in patients with elevated CA-125 levels were 94%, 75%, 98%, 50% and 96%, respectively, which were concordant with the literature. Compared to previous studies, NPV is relatively low in our study. Cystic or necrotic lesions and low grade tumor may result in FN [.sup.18]F-FDG PET/CT imaging findings (4). A hypometabolic cystic lesion on pelvic images was one of the FN results. [.sup.18]F-FDG PET has a lower sensitivity in detection of primary or recurrent mucinous carcinoma, but all FN results were from patients with a diagnosis of serous carcinoma in this study. These results may be attributed to low grade tumor or early disease progression and small lesion size at the time of PET/CT imaging. In accordance with our results, Risum et al. (17) found high sensitivity (97%) for [.sup.18]F-FDG PET/CT in patients with high CA-125 levels although they reported relatively low NPV rate (43%) due to micro or cystic/mucinous lesions.
Recurrences were primarily detected in peritoneal cavity and retroperitoneal lymph nodes in 75% of patients with ovarian cancer (18). In our study, we concordantly detected peritoneal and retroperitoneal metastases in majority of patients (41/52, 79%). PET/CT may not be able to demonstrate diffuse peritoneal involvement or small volume disease and small or necrotic lymph nodes (19,20). Rubini et al. (21) investigated the role of [.sup.18]F-FDG PET/CT in diagnosis of peritoneal carcinomatosis in patients with ovarian cancer and they reported the sensitivity, specificity, accuracy, PPV and NPV of [.sup.18]F-FDG PET/CT as 85%, 92.31%, 88.61%, 91.89% and 85.71%, respectively. In a meta-analysis which included eighteen studies, authors compared the diagnostic performances of CT, MRI and PET/CT for detection of metastatic lymph nodes in patients with ovarian cancer and they concluded that [.sup.18]F-FDG PET/CT is more accurate (sensitivity, 73.2%; specificity, 96.7%) than CT and MRI (sensitivity, 42.6% and 54.7%; specificity, 95.0% and 88.3%) (22).
One of the main advantages of PET/CT is the information about the extent and location of recurrence. Early diagnosis of recurrence and exact localization of metastatic disease are crucial for determination of the best treatment strategy. In a study, the authors reported that PET/CT findings changed clinical management in 58% of patients (23). We detected fourteen distant metastasis correctly in 12 patients with [.sup.18]F-FDG PET/CT in addition to abdominal and pelvic peritoneal metastasis in our study.
The main limitation of our study is its retrospective design. Patients were included from two different institutions and imaging techniques could not be standardized. Besides, pathological confirmation of [.sup.18]F-FDG positive lesions could not be performed in all patients.
In conclusion, [.sup.18]F-FDG PET/CT is a useful imaging method that can be used in detection of ovarian cancer recurrence in patients with elevated CA-125 levels. Since this modality offers whole body imaging, distant metastases could be detected in addition to abdominal and pelvic lesions thus contributing to patient management.
Ethics Committee Approval: The study were approved by the Adnan Menderes University of Local Ethics Committee (protocol number: 2018/1487).
Informed Consent: Consent form was filled out by all participants.
Peer-review: Externally and internally peer-reviewed.
Surgical and Medical Practices: A.C., Z.P.K., P.O.K., Y.Y., Concept: A.C., Design: A.C., Data Collection or Processing: A.C., Z.P.K., P.O.K., Y.Y., Analysis or Interpretation: A.C., Z.P.K., P.O.K., Literature Search: A.C., Writing: A.C., Y. Y.
Conflict of Interest: No conflict of interest was declared by the authors.
Financial Disclosure: The authors declared that this study received no financial support.
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(iD) Arzu Cengiz (1), (iD) Zehra Pinar Koc (2), (iD) Pelin Ozcan Kara (2), (iD) Yakup Yurekli (1)
(1) Aydin Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydin, Turkey
(2) Mersin University Faculty of Medicine, Department of Nuclear Medicine, Mersin, Turkey
Address for Correspondence: Arzu Cengiz MD, Aydin Adnan Menderes University Faculty of Medicine, Department of Nuclear Medicine, Aydin, Turkey Phone: +90 256 444 12 56 E-mail: firstname.lastname@example.org ORCID ID: orcid.org/0000-0003-2110-4450
Received: 07.11.2018 Accepted: 13.02.2019
Table 1. Positron emission tomography/computed tomography imaging findings and final diagnosis of all patients No Primary tumor CA-125 LN's above LN's below U/mL diaphragm diaphragm [SUV.sub.max] [SUV.sub.max] 1 Serous carcinoma 37.5 - 11.9 2 Serous carcinoma 1501 - 8.8 3 Mucinous carcinoma 186 - - 4 Clear cell carcinoma 87.4 22.4 29.7 5 Serous carcinoma 306 - - 6 Serous carcinoma 388.9 - 11 7 Serous carcinoma 46.9 - 9.7 8 Serous carcinoma 228 - - 9 Serous carcinoma 2740 8.1 19.4 10 Serous carcinoma 799 - 22.1 11 Serous carcinoma 129 - - 12 Serous carcinoma 546 - 3.2 13 Clear cell carcinoma 155 - 7.5 14 Serous carcinoma 85.6 - 2.6 15 Serous carcinoma 1000 - - 16 Serous carcinoma 307 - - 17 Serous carcinoma 97.3 - - 18 Serous carcinoma 287 4.3 12.3 19 Serous carcinoma 402 9.3 3.3 20 Mucinous carcinoma 77 - - 21 Serous carcinoma 57.7 7.3 19.4 22 Serous carcinoma 265 - 3.8 23 Serous carcinoma 35.8 7.7 6.6 24 Serous carcinoma 135 4.0 7.4 25 Serous carcinoma 239 9.9 13.9 26 Serous carcinoma 566 - 18.3 27 Serous carcinoma 123 7.7 8.5 28 Endometrioid carcinoma 255 - 11.7 29 Endometrioid carcinoma 990 - 11.6 30 Serous carcinoma 44.7 - 11.4 31 Serous carcinoma 921 - - 32 Serous carcinoma 100 - - 33 Serous carcinoma 77 - - 34 Endometrioid carcinoma 76 - - 35 Serous carcinoma 229 - - 36 Serous carcinoma 35.2 - - 37 Serous carcinoma 46 - 3.9 38 Serous carcinoma 86 - 2.7 39 Serous carcinoma 2678 - - 40 Serous carcinoma 36.2 - - 41 Mucinous carcinoma 64 - - 42 PNET 53.7 - 8.4 43 Clear cell carcinoma 83 - 4.4 44 Serous adenocarcinoma 144 8.5 17.1 45 Undifferentiated 45 - - carcinoma 46 Serous adenocarcinoma 1086 - - 47 Undifferentiated 41 - - carcinoma 48 Serous adenocarcinoma 282 - - 49 Serous carcinoma 91.9 - - 50 Granulosa cell tumor 76.9 - - 51 Serous carcinoma 162 - - 52 Serous adenocarcinoma 247 - - No Primary tumor Peritoneum Local Distant SUV recurrence metastasis [SUV.sub.max] [SUV.sub.max] 1 Serous carcinoma - - - 2 Serous carcinoma 9 - 3 Mucinous carcinoma 2.7 - - 4 Clear cell carcinoma 24.5 - Liver 23.1 5 Serous carcinoma 7.3 - - 6 Serous carcinoma 7.2 - - 7 Serous carcinoma - 9.7 - 8 Serous carcinoma - - - 9 Serous carcinoma 7.2 6.7 Liver 18.0 10 Serous carcinoma 13.3 - - 11 Serous carcinoma - - Lung 4.0 12 Serous carcinoma - - - 13 Clear cell carcinoma 12.6 - - 14 Serous carcinoma 11.9 - - 15 Serous carcinoma 10.5 - - 16 Serous carcinoma 9.9 - - 17 Serous carcinoma - - - 18 Serous carcinoma - 12.3 - 19 Serous carcinoma - - Pleura 14.8 20 Mucinous carcinoma - - - 21 Serous carcinoma - - - 22 Serous carcinoma 10.3 - - 23 Serous carcinoma - - Brain 14.2 24 Serous carcinoma 15.5 - Bone 16.5 25 Serous carcinoma 9.9 - Liver 11.7 26 Serous carcinoma 4.2 - - 27 Serous carcinoma 11.1 - - 28 Endometrioid carcinoma - - - 29 Endometrioid carcinoma - 22.3 - 30 Serous carcinoma - - 31 Serous carcinoma 10.5 - - 32 Serous carcinoma 13.9 - - 33 Serous carcinoma 4.1 - - 34 Endometrioid carcinoma - - - 35 Serous carcinoma 12.9 - - 36 Serous carcinoma 4.3 - - 37 Serous carcinoma - - Lung 6.6 38 Serous carcinoma - - - 39 Serous carcinoma - - Liver 8.3 40 Serous carcinoma - - - 41 Mucinous carcinoma 10.5 - - 42 PNET - - - 43 Clear cell carcinoma - - - 44 Serous adenocarcinoma - - Lung 4.2 Liver 9.6 45 Undifferentiated 4.1 - Liver, 15.8 carcinoma 46 Serous adenocarcinoma - 22.2 - 47 Undifferentiated - - Bone 18 carcinoma Liver 14.1 48 Serous adenocarcinoma 3.8 8.9 - 49 Serous carcinoma 4.8 - - 50 Granulosa cell tumor - - - 51 Serous carcinoma - 11.3 - 52 Serous adenocarcinoma 12.9 - Liver 7.5 No Primary tumor Final result 1 Serous carcinoma TP 2 Serous carcinoma TP 3 Mucinous carcinoma TP 4 Clear cell carcinoma TP 5 Serous carcinoma TP 6 Serous carcinoma TP 7 Serous carcinoma TP 8 Serous carcinoma FN 9 Serous carcinoma TP 10 Serous carcinoma TP 11 Serous carcinoma FP 12 Serous carcinoma TP 13 Clear cell carcinoma TP 14 Serous carcinoma TP 15 Serous carcinoma TP 16 Serous carcinoma TP 17 Serous carcinoma FN 18 Serous carcinoma TP 19 Serous carcinoma TP 20 Mucinous carcinoma TN 21 Serous carcinoma TP 22 Serous carcinoma TP 23 Serous carcinoma TP 24 Serous carcinoma TP 25 Serous carcinoma TP 26 Serous carcinoma TP 27 Serous carcinoma TP 28 Endometrioid carcinoma TP 29 Endometrioid carcinoma TP 30 Serous carcinoma TP 31 Serous carcinoma TP 32 Serous carcinoma TP 33 Serous carcinoma TP 34 Endometrioid carcinoma TN 35 Serous carcinoma TP 36 Serous carcinoma TP 37 Serous carcinoma TP 38 Serous carcinoma TP 39 Serous carcinoma TP 40 Serous carcinoma FN 41 Mucinous carcinoma TP 42 PNET TP 43 Clear cell carcinoma TP 44 Serous adenocarcinoma TP 45 Undifferentiated TP carcinoma 46 Serous adenocarcinoma TP 47 Undifferentiated TP carcinoma 48 Serous adenocarcinoma TP 49 Serous carcinoma TP 50 Granulosa cell tumor TN 51 Serous carcinoma TP 52 Serous adenocarcinoma TP TP: True positive, FP: False positive, TN: True negative, FN: False negative, PNET: Primitive neuroectodermal tumor, SUV: Standardited uptake values Table 2. Detailed results of [.sup.18]F-FDG positron emission tomography/computed tomography according to CA-125 levels CA-125 levels (U/mL) TP (n) FP (n) TN (n) FN (n) <100 17 0 3 2 [greater than or equal to]100 28 1 0 1 CA-125 levels (U/mL) Sensitivity % Specificity % <100 89 100 [greater than or equal to]100 97 - TP: True positive, FP: False positive, TN: True negative, FN: False negative
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|Title Annotation:||Original Article|
|Author:||Cengiz, Arzu; Koc, Zehra Pinar; Kara, Pelin Ozcan; Yurekli, Yakup|
|Publication:||Molecular Imaging and Radionuclide Therapy|
|Date:||Feb 1, 2019|
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